!!Eugene Vasilevich Grishin - Curriculum Vitae \\ __Education and employment:__ \\ *Deputy Director of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences *Professor of Department Bioorganic Chemistry, M.V.Lomonosov Moscow State University, Biological Faculty \\ __Education:__ *M.Sc. in Chemistry, 1969, Moscow State University Chemical Department *Ph.D. in Chemistry, 1973, Shemyakin Institute of Bioorganic Chemistry *D.Sc. in Chemistry, 1985, Shemyakin Institute of Bioorganic Chemistry \\ __Professional Experience:__ \\ *1967-1969 M.Sc. thesis, Moscow State University. *1969-1976 Junior Scientist, Shemyakin Institute of Bioorganic Chemistry. *1976-1987 Senior Scientist, Shemyakin Institute of Bioorganic Chemistry. *1987-present Head of the Laboratory for Neuroreceptors and Neuroregulators, Shemyakin Institute of Bioorganic Chemistry *1988-present Deputy Director of Shemyakin Institute of Bioorganic Chemistry. *1988-present Professor of Biological Department of Moscow State University. *1990-present Professor of Shemyakin Institute of Bioorganic Chemistry. *1997-present Corresponding Member of Russian Academy of Sciences \\ __Research Activities:__ \\ *__Protein Chemistry:__ primary structure of cytoplasmic aspartate aminotransferase from pig heart muscle, structure of latrotoxins, protein modification and crystallization. *__Toxinology:__ isolation of polypeptide toxins from snake, scorpion , spider and ant venoms; structure of polypeptide toxins; tetrodotoxin modification; structure-function relationships of natural toxins; spatial structure of polypeptide toxins; cloning of cDNA encoding protein toxins; analysis of spider venom EST databases, functional expression and mutagenesis of polypeptide toxins; polyamine spider toxins; neurotoxins as tools for study of receptor components. *__Neuroreceptors:__ interaction of natural neurotoxins with sodium and potassium channels; isolation of sodium channel components from rat brain; α-latrotoxin receptor from bovine brain; latrophilin; glutamate receptor, hERG channel, TRPV1 and P2X receptors. Electrophysiology of ionic channels, receptor expression in Xenopus oocytes, recombinant DNA technique: site-directed mutagenesis, PCR techniques. \\ \\ __Other Skills and Experience:__ \\ Electrophysiology of ionic channels, receptor expression in Xenopus oocytes. Recombinant DNA technique: site-directed mutagenesis, PCR techniques, hybridization and immunological screening of recombinant products; expression systems for genetically engineered proteins. \\ \\ __Current interests:__ \\ Toxinology and Molecular Neurobiology in general \\ \\ __Teaching Experience:__ \\ *Protein chemistry *Biochemistry *Natural toxins *Membrane transport systems \\ __Affiliations:__ \\ *Russian Biochemistry Society *Russian Society for Neurochemistry *European Society for Neurochemistry *International Society for Neurochemistry *International Society of Toxinology \\ __Honours:__ \\ *1975 State Jr. Scientist Prize *1981 State Citizenship Award *1985 State Research Prize *1994 Ovchinnikov Prize Russian Acad. Sci. *2003-present President of Russian Society for Neurochemistry *2004 Member of Academia Europaea *2004 Doctor Honoris Causa of Universidad Nacional Mayor de San Marcos (Lima, Peru) *2004 Doctor Honoris Causa of Universidad Ricardo Palma (Lima, Peru) \\ __Publications:__ \\ ~320 Papers and Abstracts