!!Anna Katharina Simon - Publications
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__Selection of recent publications  (ORCID 0000-0002-4077-7995)__\\
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1)	Borsa, M. …l, A.K. Simon. Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism. Autophagy (2023) This describes the mechanism by which stem cells without autophagy are lost. \\
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This knowledge can be used to treat diseases where decreased autophagy is a key component of the pathogenesis. \\
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2)	Richter, F. C. …. A.K. Simon, Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL‐10. EMBO J (2023).\\
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First evidence for a role of cell-extrinsic autophagy in inflammation in vivo.\\
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3)	Yao Y, Du Jiang P, Chao BN, Cagdas D, Kubo S, Balasubramaniyam A, et al. GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans. J Exp Med. 2022;219(6). \\
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An example of an immune deficiency based on a mutated molecule in the autophagy signalling pathway.\\
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4)	Zhou, D., M. Borsa, D. Puleston,…, Behrends*, G. Alsaleh*, and A.K. Simon*. 2021. Mapping of the autophagosomal degradome identifies IL-7Rα as key 1 cargo in proliferating CD4+ T-cells. Nat Comms 13, 5174, (2022) \\
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A novel proximity labelling mouse model that can identify autophagosomal cargo in vivo.\\
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5)	Zhang, H. …, Simon, AK. Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. Mol Cell 76, 110-125 e119 (2019). \\
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This study identified a novel translational pathway that controls autophagy in B cells. This pathway has since become a key pathway downstream of polyamines.\\
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6)	Clarke, A. J. & Simon, A. K. Autophagy in the renewal, differentiation and homeostasis of immune cells. Nat Rev Immunol 19, 170-183 (2019). We pioneered this field and were asked to provide this review.\\
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7)	Clarke, A. J., Riffelmacher, T, Braas, D., Cornall, R.J., Simon, A.K. \\
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B1a B cells require autophagy for metabolic homeostasis and self-renewal. J Exp Med 215 399-413 (2018). \\
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B1a cells are long-lived & self-renewing, another example of a cell type with stem cell characteristics addicted to autophagy.\\
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8)	Riffelmacher, T., Clarke, A., Richter, et al, Jacobsen, S. E. W. & Simon, A. K. Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation. Immunity 47, 466-480 e465, (2017). \\
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This study identifies the mechanism behind the requirement for autophagy in cellular differentiation This paper washighlighted in a preview in Immunity by Klaus Ley et al (same issue) and in Nature Reviews Immunology doi:10.1038/nri.2017.122 \\
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9)	Puleston, D. J., Zhang, H., Powell, et al, Klenerman, P. & Simon, A. K. Autophagy is a critical regulator of memory CD8(+) T cell formation. Elife 3 (2014). \\
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This paper gave rise to a patent and paved the way for a clinical trial using the polyamine spermidine to improve vaccine responses in elderly humans.\\
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10)	Mortensen, M., Soilleux, E. J., Djordjevic, G., … Jacobsen, S. E., Kranc, K. R. & Simon, A. K. The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J Exp Med 208, 455-467 (2011). \\
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This was the first report on the key role of autophagy in stem cells, cited 647 times.\\ \\[{ALLOW view All}][{ALLOW edit asimon6938}][{ALLOW upload asimon6938}][{ALLOW comment All}]