!!Catharina Svanborg - Publications
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__2012__
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*Alternatively folded proteins with unexpected beneficial functions
*Comparison of Asymptomatic Bacteriuria Escherichia coli Isolates from Healthy Individuals versus Those from Hospital Patients Shows that Long-Term Bladder Colonization Selects for Attenuated Virulence Phenotypes
*Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire?
*HAMLET Forms Annular Oligomers When Deposited with Phospholipid Monolayers
*HAMLET: functional properties and therapeutic potential.
*Susceptibility to acute pyelonephritis or asymptomatic bacteriuria: Host-pathogen interaction in urinary tract infections.
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__2011__
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*Acute pyelonephritis and renal scarring are caused by dysfunctional innate immunity in mCxcr2 heterozygous mice.
*Apoptosis-Like Death in Bacteria Induced by HAMLET, a Human Milk Lipid-Protein Complex
*Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis.
*Genetic control of the variable innate immune response to asymptomatic bacteriuria.
*Genetics of innate immunity and UTI susceptibility.
*HAMLET Binding to α-Actinin Facilitates Tumor Cell Detachment.
*MiR-129-5p is required for histone deacetylase inhibitor-induced cell death in thyroid cancer cells
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__2010__
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*HAMLET Interacts with Lipid Membranes and Perturbs Their Structure and Integrity
*HAMLET Treatment Delays Bladder Cancer Development.
*HAMLET interacts with lipid membranes and perturbs their structure and integrity.
*Host Imprints on Bacterial Genomes-Rapid, Divergent Evolution in Individual Patients
*Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence.
*Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection.
*Structure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes.
*Toll-Like Receptor 4 Promoter Polymorphisms: Common TLR4 Variants May Protect against Severe Urinary Tract Infection.
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__2009__
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*Changes in proteasome structure and function caused by HAMLET in tumor cells.
*Characterizing Escherichia coli asymptomatic bacteriuria (ABU) - what drives their successful silent colonization?
*HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death.
*Therapeutic Effect of Blocking CXCR2 on Neutrophil Recruitment and Dextran Sodium Sulfate-Induced Colitis
*Virulence properties of asymptomatic bacteriuria Escherichia coli alpha-Lactalbumin, Engineered to be Non-native and **Inactive, Kills Tumor Cells when in Complex with Oleic Acid: A new biological function resulting from partial unfolding.
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__2008__
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*Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells).
*Asymptomatic Bacteriuria: An adaptive challenge for Escherichia coli within the urinary tract
*Can misfolded proteins be beneficial? The HAMLET case.
*Effects of epithelial and neutrophil CXCR2 on innate immunity and resistance to kidney infection.
*Molecular basis of commensalism in the urinary tract: low virulence or virulence attenuation?
*Pathogenomics: An updated European Research Agenda
*Shiga toxin-mediated disease in MyD88-deficient mice infected with Escherichia coli O157:H7.
*Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins
*TLR- and CXCR1-dependent innate immunity: insights into the genetics of urinary tract infections.
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__2007__
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*A genetic basis of susceptibility to acute pyelonephritis.
*Bladder cancers respond to intravesical instillation of (HAMLET human alpha-lactalbumin made lethal to tumor cells).
*Ceramide as a TLR4 agonist; a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4.
*Do type 1 fimbriae promote inflammation in the human urinary tract?
*Fimbrial lectins influence the chemokine repertoire in the urinary tract mucosa.
*HAMLET, protein folding, and tumor cell death
*Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET.
*Inherited susceptibility to acute pyelonephritis: a family study of urinary tract infection.
*Reduced Toll-like receptor 4 expression in children with asymptomatic bacteriuria
*Urinary tract infections revisited.
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__2006__
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*Glycolipid receptor depletion as an approach to specific antimicrobial therapy.
*HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53.
*Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets via TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome.
*Mechanism of pathogen-specific TLR4 activation in the mucosa: Fimbriae, recognition receptors and adaptor protein selection.
*Molecular characterization of the Escherichia coli asymptomatic bacteriuria strain 83972: The taming of a pathogen
*Uropathogenic Escherichia coli as a model of host-parasite interaction.
*alpha-Lactalbumin species variation, HAMLET formation, and tumor cell death.
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__2005__
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*Compact oleic acid in HAMLET.
*Escherichia coli, fimbriae, bacterial persistence and host response induction in the human urinary tract.
*Expression of nitric oxide synthase isoforms in the mouse kidney: cellular localization and influence by lipopolysaccharide and Toll-like receptor 4.
*HAMLET kills tumor cells by apoptosis: Structure, cellular mechanisms, and therapy
*HAMLET; a novel tool to identify apoptotic pathways in tumor cells.
*Natural history of renal scarring in susceptible mIL-8Rh-/- mice.
*Neutrophil activation and renal scarring - Reply
*Stability of HAMLET--A kinetically trapped {alpha}-lactalbumin oleic acid complex.
*Urinary tract infections and the mucosal Immune system
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__2004__
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*Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of alpha-lactalbumin
*Conformational analysis of HAMLET, the folding variant of human alpha-lactalbumin associated with apoptosis
*Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival.
*PapG-dependent adherence breaks mucosal inertia and triggers the innate host response
*Toll-like receptor 4 expression and cytokine responses in the human urinary tract mucosa.
*Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid
*Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid.
*Urinary tract infections as a model for innate mucosal immunity
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__2003__
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*Analysis of genome plasticity in pathogenic and commensal Escherichia coli isolates by use of DNA arrays
*Der Einfluss von P-Fimbrien auf eine Leukozyturie und den Schwellenwert einer persistierenden Bakteriurie Effect of P fimbriae on pyuria and bacterial colonization of the human urinary tract
*Glycolipid depletion in antimicrobial therapy
*HAMLET interacts with histones and chromatin in tumor cell nuclei.
*HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects.
*Lipids as cofactors in protein folding: Stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells).
*The host response to urinary tract infection.
*alpha-Lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).
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__2002__
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*Adhesion, signal transduction and mucosal inflammation
*Hamlet - A complex from human milk that induces apoptosis in tumor cells but spares healthy cells
*Hamlet--a complex from human milk that induces apoptosis in tumor cells but spares healthy cells.
*Human renal epithelial cells express iNOS in response to cytokines but not bacteria.
*The role of P fimbriae for Escherichia coli establishment and mucosal inflammation in the human urinary tract.
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__2001__
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*A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria
*Carbohydrate receptor depletion as an antimicrobial strategy for prevention of urinary tract infection
*Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation
*Escherichia coli-induced inducible nitric oxide synthase and cyclooxygenase expression in the mouse bladder and kidney
*Fimbriae, transmembrane signaling, and cell activation
*Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephritis
*Neutrophil recruitment, chemokine receptors, and resistance to mucosal infection
*The 'innate' host response protects and damages the infected urinary tract
*The millenium symposium on pyelonephritis and urinary tract infection - Lund, Sweden, 24-26 May 2000 - Introduction
*Toll-like receptor signaling and chemokine receptor expression influence the severity of urinary tract infection
*Type 1 fimbriae deliver an LPS- and TLR4-dependent activation signal to CD14-negative cells
*Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo
*pap genotype and P fimbrial expression in Escherichia coli causing bacteremic and nonbacteremic febrile urinary tract infection
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__2000__
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*Innate defences and resistance to gram negative mucosal infection
*Interleukin 8 receptor deficiency confers susceptibility to acute experimental pyelonephritis and may have a human counterpart
*Interleukin-8 receptor knockout mice have subepithelial neutrophil entrapment and renal scarring following acute pyelonephritis
*Transepithelial neutrophil migration is CXCR1 dependent in vitro and is defective in IL-8 receptor knockout mice
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__1999__
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*Cytokine responses during mucosal infections: role in disease pathogenesis and host defence
*Macrophage inflammatory protein-2 is required for neutrophil passage across the epithelial barrier of the infected urinary tract
*Neutrophil recruitment and resistance to urinary tract infection
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__1998__
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*Role of fimbriae-mediated adherence for neutrophil migration across Escherichia coli-infected epithelial cell layers
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__1997__
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*Bacterial virulence in urinary tract infection
*Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration
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