Wolfgang F. Graier - Peer reviewed publications#
2024
George, M; Allerkamp, HH; Koshenov, Z; Oflaz, FE; Tam-Amersdorfer, C; Kolesnik, T; Rittchen, S; Lang, M; Fröhlich, E; Graier, W; Strobl, H; Wadsack, CLiver X receptor activation mitigates oxysterol-induced dysfunction in fetoplacental endothelial cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2024; 1869(3):159466 Doi: 10.1016/j.bbalip.2024.159466
Gottschalk, B; Koshenov, Z; Malli, R; Graier, WFImplications of mitochondrial membrane potential gradients on signaling and ATP production analyzed by correlative multi-parameter microscopy. Sci Rep. 2024; 14(1):14784 Doi: 10.1038/s41598-024-65595-z OPEN ACCESS
Pilic, J; Gottschalk, B; Bourgeois, B; Habisch, H; Koshenov, Z; Oflaz, FE; Erdogan, YC; Miri, SM; Yiğit, EN; Aydın, MŞ; Öztürk, G; Eroglu, E; Shoshan-Barmatz, V; Madl, T; Graier, WF; Malli, RHexokinase 1 forms rings that regulate mitochondrial fission during energy stress. Mol Cell. 2024; Doi: 10.1016/j.molcel.2024.06.009
2023
Deak, AT; Belić, K; Meissl, AM; Artinger, K; Eller, K; Rechberger, B; Niedrist, T; Graier, WF; Malli, R; Bischof, H; Burgstaller, S; Blass, S; Avian, A; Rosenkranz, AR; Kirsch, AHSalivary potassium measured by genetically encoded potassium ion indicators as a surrogate for plasma potassium levels in hemodialysis patients-a proof-of-concept study. Nephrol Dial Transplant. 2023; 38(3):757-763 Doi: 10.1093/ndt/gfac195
Goeritzer, M; Kuentzel, KB; Beck, S; Korbelius, M; Rainer, S; Bradić, I; Kolb, D; Mussbacher, M; Schrottmaier, WC; Assinger, A; Schlagenhauf, A; Rost, R; Gottschalk, B; Eichmann, TO; Züllig, T; Graier, WF; Vujić, N; Kratky, DMonoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice. Int J Mol Sci. 2023; 24(4): 3116 Doi: 10.3390/ijms24043116 OPEN ACCESS
Held, A; Lapka, J; Sargeant, J; Hojanazarova, J; Shaheen, A; Galindo, S; Madreiter-Sokolowski, C; Malli, R; Graier, WF; Hay, JCSTEADY-STATE REGULATION OF COPII-DEPENDENT SECRETORY CARGO SORTING BY INOSITOL TRISPHOSPHATE RECEPTORS, CALCIUM, AND PENTA EF HAND PROTEINS. J Biol Chem. 2023; 105471 Doi: 10.1016/j.jbc.2023.105471 OPEN ACCESS
Kaufmann, L; Pilic, J; Auinger, L; Mayer, AL; Blatterer, J; Semmler-Bruckner, J; Abbas, S; Rehman, K; Ayaz, M; Graier, WF; Malli, R; Petek, E; Wagner, K; Al, Kaissi, A; Khan, MA; Windpassinger, CAnalysis of a non-lethal biallelic frameshift mutation in ZMPSTE24 reveals utilization of alternative translation initiation codons. Clin Genet. 2023; Doi: 10.1111/cge.14381
Klepcova, Z; Spakova, I; Madreiter-Sokolowski, CT; Graier, W; Kalinova, K; Samolova, E; Smolkova, R; Smolko, L; Rabajdova, MInvestigation of novel Mn(II) fenamato complexes with neocuproine and their effects on endometrial cell lines. NEW J CHEM. 2023; Doi: 10.1039/d3nj00412k
Oflaz, FE; Koshenov, Z; Hirtl, M; Bachkoenig, OA; Graier, WF; Gottschalk, BSynergy of uncoupling proteins (1 and 2) with mitochondrial Ca2+ uptake machinery potentiate mitochondrial uncoupling. Cell Calcium. 2023; 112:102736 Doi: 10.1016/j.ceca.2023.102736
Gottschalk, B; Malli, R; Graier, WFMICU1 deficiency alters mitochondrial morphology and cytochrome C release. Cell Calcium. 2023; 113: 102765 Doi: 10.1016/j.ceca.2023.102765
2022
Anand, U; Shteinfer-Kuzmine, A; Sela, G; Santhanam, M; Gottschalk, B; Boujemaa-Paterski, R; Medalia, O; Graier, WF; Shoshan-Barmatz, VThe Multicellular Effects of VDAC1 N-Terminal-Derived Peptide. Biomolecules. 2022; 12(10): Doi: 10.3390/biom12101387 OPEN ACCESS
Bachkoenig, OA; Gottschalk, B; Malli, R; Graier, WFAn unexpected effect of risperidone reveals a nonlinear relationship between cytosolic Ca2+ and mitochondrial Ca2+ uptake. Curr Top Membr. 2022; 90: 13-35. Doi: 10.1016/bs.ctm.2022.09.001
Goeritzer, M; Schlager, S; Kuentzel, KB; Vujić, N; Korbelius, M; Rainer, S; Kolb, D; Mussbacher, M; Salzmann, M; Schrottmaier, WC; Assinger, A; Schlagenhauf, A; Madreiter-Sokolowski, CT; Blass, S; Eichmann, TO; Graier, WF; Kratky, DAdipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo. Cells. 2022; 11(5): Doi: 10.3390/cells11050850 OPEN ACCESS
Gottschalk, B; Koshenov, Z; Bachkoenig, OA; Rost, R; Malli, R; Graier, WFMFN2 mediates ER-mitochondrial coupling during ER stress through specialized stable contact sites. Front Cell Dev Biol. 2022; 10: 918691 Doi: 10.3389/fcell.2022.918691 OPEN ACCESS
Gottschalk, B; Koshenov, Z; Waldeck-Weiermair, M; Radulović, S; Oflaz, FE; Hirtl, M; Bachkoenig, OA; Leitinger, G; Malli, R; Graier, WFMICU1 controls spatial membrane potential gradients and guides Ca2+ fluxes within mitochondrial substructures. Commun Biol. 2022; 5(1): 649 Doi: 10.1038/s42003-022-03606-3 OPEN ACCESS
Joshi, L; Plastira, I; Bernhart, E; Reicher, H; Koshenov, Z; Graier, WF; Vujic, N; Kratky, D; Rivera, R; Chun, J; Sattler, WLysophosphatidic Acid Receptor 5 (LPA5) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In Vitro.Cells. 2022; 11(7): Doi: 10.3390/cells11071071 OPEN ACCESS
Klec, C; Knutsen, E; Schwarzenbacher, D; Jonas, K; Pasculli, B; Heitzer, E; Rinner, B; Krajina, K; Prinz, F; Gottschalk, B; Ulz, P; Deutsch, A; Prokesch, A; Jahn, SW; Lellahi, SM; Perander, M; Barbano, R; Graier, WF; Parrella, P; Calin, GA; Pichler, MALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform. Cell Mol Life Sci. 2022; 79(7): 391 Doi: 10.1007/s00018-022-04402-2 OPEN ACCESS
Koshenov, Z; Oflaz, FE; Hirtl, M; Gottschalk, B; Rost, R; Malli, R; Graier, WFCitrin mediated metabolic rewiring in response to altered basal subcellular Ca2+ homeostasis. Commun Biol. 2022; 5(1): 76 Doi: 10.1038/s42003-022-03019-2 OPEN ACCESS
Oflaz, FE; Koshenov, Z; Hirtl, M; Rost, R; Malli, R; Graier, WFSigma-1 Receptor Modulation by Ligands Coordinates Cancer Cell Energy Metabolism. Biomolecules. 2022; 12(6): Doi: 10.3390/biom12060762 OPEN ACCESS
Sevimli, G; Alston, AE; Funk, F; Flühmann, B; Malli, R; Graier, WF; Eroglu, EProbing Subcellular Iron Availability with Genetically Encoded Nitric Oxide Biosensors. Biosensors (Basel). 2022; 12(10): Doi: 10.3390/bios12100903 OPEN ACCESS
Tawfik, I; Gottschalk, B; Jarc, A; Bresilla, D; Rost, R; Obermayer-Pietsch, B; Graier, WF; Madreiter-Sokolowski, CTT3-induced enhancement of mitochondrial Ca2+ uptake as a boost for mitochondrial metabolism. Free Radic Biol Med. 2022; 181:197-208 Doi: 10.1016/j.freeradbiomed.2022.01.024
Gottschalk, B; Madreiter-Sokolowski, CT; Graier, WFCristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics. Cell Calcium. 2022; 101:102517 Doi: 10.1016/j.ceca.2021.102517
Lindenmann, J; Kamolz, L; Graier, W; Smolle, J; Smolle-Juettner, FMHyperbaric Oxygen Therapy and Tissue Regeneration: A Literature Survey. Biomedicines. 2022; 10(12): Doi: 10.3390/biomedicines10123145 OPEN ACCESS
Eroglu, E; Graier, WF; Malli, RThe preamble to the free radical biology and medicine virtual special issue on "Targeting genetic biosensors to intracellular signaling pathways". Free Radic Biol Med. 2022; 187: 202-203. Doi: 10.1016/j.freeradbiomed.2022.05.026
2021
Bischof, H; Burgstaller, S; Graier, WF; Lukowski, R; Malli, RUnveiling the K+-sensitivity of cell metabolism using genetically encoded, FRET-based K+, glucose, and ATP biosensors. STAR Protoc. 2021; 2(4): 100843 Doi: 10.1016/j.xpro.2021.100843 OPEN ACCESS
Bischof, H; Burgstaller, S; Springer, A; Matt, L; Rauter, T; Bachkönig, OA; Schmidt, T; Groschner, K; Schindl, R; Madl, T; Plesnila, N; Lukowski, R; Graier, WF; Malli, RPotassium ions promote hexokinase-II dependent glycolysis. iScience. 2021; 24(4): 102346-102346. Doi: 10.1016/j.isci.2021.102346 OPEN ACCESS
Bluemel, G; Planque, M; Madreiter-Sokolowski, CT; Haitzmann, T; Hrzenjak, A; Graier, WF; Fendt, SM; Olschewski, H; Leithner, KPCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells. Free Radic Biol Med. 2021; 176:34-45 Doi: 10.1016/j.freeradbiomed.2021.09.007
Burgstaller, S; Bischof, H; Lukowski, R; Graier, WF; Malli, RInvestigating the K+ sensitivity of cellular metabolism by extracellular flux analysis. STAR Protoc. 2021; 2(4): 100876 Doi: 10.1016/j.xpro.2021.100876 OPEN ACCESS
Burgstaller, S; Bischof, H; Rauter, T; Schmidt, T; Schindl, R; Patz, S; Groschup, B; Filser, S; van, den, Boom, L; Sasse, P; Lukowski, R; Plesnila, N; Graier, WF; Malli, RImmobilization of Recombinant Fluorescent Biosensors Permits Imaging of Extracellular Ion Signals.ACS Sens. 2021; 6(11):3994-4000 Doi: 10.1021/acssensors.1c01369 OPEN ACCESS
Deak, AT; Jean-Quartier, C; Bondarenko, AI; Groschner, LN; Malli, R; Graier, WF; Waldeck-Weiermair, MAssessment of Mitochondrial Ca2+ Uptake. Methods Mol Biol. 2021; 2276: 173-191. Doi: 10.1007/978-1-0716-1266-8_13
Joshi, L; Plastira, I; Bernhart, E; Reicher, H; Koyani, CN; Madl, T; Madreiter-Sokolowski, C; Koshenov, Z; Graier, WF; Hallström, S; Sattler, WLysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased qmino Acid Uptake in BV-2 Microglia. Int J Mol Sci. 2021; 22(4): Doi: 10.3390/ijms22041968 OPEN ACCESS
Koshenov, Z; Oflaz, FE; Hirtl, M; Pilic, J; Bachkoenig, OA; Gottschalk, B; Madreiter-Sokolowski, CT; Rost, R; Malli, R; Graier, WFSigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca2+ Leak during Early ER Stress. Metabolites. 2021; 11(7): Doi: 10.3390/metabo11070422 OPEN ACCESS
Madreiter-Sokolowski, CT; Gottschalk, B; Sokolowski, AA; Malli, R; Graier, WFDynamic Control of Mitochondrial Ca2+ Levels as a Survival Strategy of Cancer Cells. Front Cell Dev Biol. 2021; 9:614668-614668 Doi: 10.3389/fcell.2021.614668 OPEN ACCESS
Oflaz, FE; Koshenov, Z; Hirtl, M; Rost, R; Bachkoenig, OA; Gottschalk, B; Madreiter-Sokolowski, CT; Malli, R; Graier, WFNear-UV Light Induced ROS Production Initiates Spatial Ca2+ Spiking to Fire NFATc3 Translocation. Int J Mol Sci. 2021; 22(15): 8189 Doi: 10.3390/ijms22158189 OPEN ACCESS
Špaková, I; Rabajdová, M; Mičková, H; Graier, WF; Mareková, MEffect of hypoxia factors gene silencing on ROS production and metabolic status of A375 malignant melanoma cells.Sci Rep. 2021; 11(1): 10325-10325. Doi: 10.1038/s41598-021-89792-2 OPEN ACCESS
Sargeant, J; Seiler, DK; Costain, T; Madreiter-Sokolowski, CT; Gordon, DE; Peden, AA; Malli, R; Graier, WF; Hay, JCALG-2 and peflin regulate COPII targeting and secretion in response to calcium signaling. J Biol Chem. 2021; 297(6):101393 Doi: 10.1016/j.jbc.2021.101393 OPEN ACCESS
Somlapura, M; Gottschalk, B; Lahiri, P; Kufferath, I; Pabst, D; Rülicke, T; Graier, WF; Denk, H; Zatloukal, KDifferent Roles of p62 (SQSTM1) Isoforms in Keratin-Related Protein Aggregation. Int J Mol Sci. 2021; 22(12): Doi: 10.3390/ijms22126227 OPEN ACCESS
Cavinato, M; Madreiter-Sokolowski, CT; Büttner, S; Schosserer, M; Zwerschke, W; Wedel, S; Grillari, J; Graier, WF; Jansen-Dürr, PTargeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control. FEBS J. 2021; 288(12):3834-3854 Doi: 10.1111/febs.15631 OPEN ACCESS
Lindenmann, J; Smolle, C; Kamolz, LP; Smolle-Juettner, FM; Graier, WF Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair. Int J Mol Sci. 2021; 22(21): Doi: 10.3390/ijms222111754 OPEN ACCESS
2020
Bourgeois, B; Hutten, S; Gottschalk, B; Hofweber, M; Richter, G; Sternat, J; Abou-Ajram, C; Göbl, C; Leitinger, G; Graier, WF; Dormann, D; Madl, TNonclassical nuclear localization signals mediate nuclear import of CIRBP. Proc Natl Acad Sci U S A. 2020; 117(15): 8503-8514. Doi: 10.1073/pnas.1918944117 OPEN ACCESS
Goeritzer, M; Bernhart, E; Plastira, I; Reicher, H; Leopold, C; Eichmann, TO; Rechberger, G; Madreiter-Sokolowski, CT; Prasch, J; Eller, P; Graier, WF; Kratky, D; Malle, E; Sattler, WMyeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro. Int J Mol Sci. 2020; 21(3): Doi: 10.3390/ijms21031143 OPEN ACCESS
Koshenov, Z; Oflaz, FE; Hirtl, M; Bachkoenig, OA; Rost, R; Osibow, K; Gottschalk, B; Madreiter-Sokolowski, CT; Waldeck-Weiermair, M; Malli, R; Graier, WFThe contribution of uncoupling protein 2 to mitochondrial Ca2+ homeostasis in health and disease - A short revisit. Mitochondrion. 2020; 55(10):164-173 Doi: 10.1016/j.mito.2020.10.003 OPEN ACCESS
Špaková, I; Graier, WF; Rabajdová, M; Dubayová, K; Nagyová, V; Mareková, MHypoxia factors suppression effect on the energy metabolism of a malignant melanoma cell SK-MEL-30. Eur Rev Med Pharmacol Sci. 2020; 24(9): 4909-4920. Doi: 10.26355/eurrev_202005_21180
Radulović, S; Gottschalk, B; Hörl, G; Zardoya-Laguardia, P; Schilcher, I; Hallström, S; Vujić, N; Schmidt, K; Trieb, M; Graier, WF; Malli, R; Kratky, D; Marsche, G; Frank, SEndothelial lipase increases eNOS activating capacity of high-density lipoprotein.Biochim Biophys Acta Mol Cell Biol Lipids. 2020; 1865(4):158612 Doi: 10.1016/j.bbalip.2020.158612 OPEN ACCESS
Rauter, T; Burgstaller, S; Gottschalk, B; Ramadani-Muja, J; Bischof, H; Hay, JC; Graier, WF; Malli, RER-to-Golgi Transport in HeLa Cells Displays High Resilience to Ca2+ and Energy Stresses. Cells. 2020; 9(10): Doi: 10.3390/cells9102311 OPEN ACCESS
Rauter, T; Depaoli, MR; Bischof, H; Graier, WF; Malli, RMetabolic Profiling of Single Cancer Cells Using Mitochondrial ATP Probes. STAR Protoc. 2020; 1(2): 100048-100048. Doi: 10.1016/j.xpro.2020.100048 OPEN ACCESS
Wallner, M; Eaton, DM; Berretta, RM; Liesinger, L; Schittmayer, M; Gindlhuber, J; Wu, J; Jeong, MY; Lin, YH; Borghetti, G; Baker, ST; Zhao, H; Pfleger, J; Blass, S; Rainer, PP; von Lewinski, D; Bugger, H; Mohsin, S; Graier, WF; Zirlik, A; McKinsey, TA; Birner-Gruenberger, R; Wolfson, MR; Houser, SRHDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction. Sci Transl Med. 2020; 12(525): Doi: 10.1126/scitranslmed.aay7205 OPEN ACCESS
Eroglu, E; Michel, T; Graier, WF; Malli, RYes (again) to local NO. Nat Chem Biol. 2020; 16(6):606-607 Doi: 10.1038/s41589-020-0552-7
2019
Bischof, H; Burgstaller, S; Vujic, N; Madl, T; Kratky, D; Graier, WF; Malli, RPurification and Application of Genetically Encoded Potassium Ion Indicators for Quantification of Potassium Ion Concentrations within Biological Samples. Curr Protoc Chem Biol. 2019; 11(3): e71-e71. Doi: 10.1002/cpch.71 OPEN ACCESS
Gottschalk, B; Klec, C; Leitinger, G; Bernhart, E; Rost, R; Bischof, H; Madreiter-Sokolowski, CT; Radulović, S; Eroglu, E; Sattler, W; Waldeck-Weiermair, M; Malli, R; Graier, WF. MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex. Nat Commun. 2019; 10(1):3732-3732 Doi: 10.1038/s41467-019-11692-x OPEN ACCESS
Hofer, DC; Zirkovits, G; Pelzmann, HJ; Huber, K; Pessentheiner, AR; Xia, W; Uno, K; Miyazaki, T; Kon, K; Tsuneki, H; Pendl, T; Al Zoughbi, W; Madreiter-Sokolowski, CT; Trausinger, G; Abdellatif, M; Schoiswohl, G; Schreiber, R; Eisenberg, T; Magnes, C; Sedej, S; Eckhardt, M; Sasahara, M; Sasaoka, T; Nitta, A; Hoefler, G; Graier, WF; Kratky, D; Auwerx, J; Bogner-Strauss, JGN-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health. FASEB J. 2019; 33(12):13808-13824 Doi: 10.1096/fj.201801323R OPEN ACCESS
Huber, K; Hofer, DC; Trefely, S; Pelzmann, HJ; Madreiter-Sokolowski, C; Duta-Mare, M; Schlager, S; Trausinger, G; Stryeck, S; Graier, WF; Kolb, D; Magnes, C; Snyder, NW; Prokesch, A; Kratky, D; Madl, T; Wellen, KE; Bogner-Strauss, JGN-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes. Biochim Biophys Acta Mol Cell Res. 2019; 1866(3): 337-348. Doi: 10.1016/j.bbamcr.2018.08.017 OPEN ACCESS
Klec, C; Madreiter-Sokolowski, CT; Stryeck, S; Sachdev, V; Duta-Mare, M; Gottschalk, B; Depaoli, MR; Rost, R; Hay, J; Waldeck-Weiermair, M; Kratky, D; Madl, T; Malli, R; Graier, WFGlycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells.
Cell Physiol Biochem. 2019; 52(1): 57-75. Doi: 10.33594/000000005 OPEN ACCESS
Klec, C; Madreiter-Sokolowski, CT; Ziomek, G; Stryeck, S; Sachdev, V; Duta-Mare, M; Gottschalk, B; Depaoli, MR; Rost, R; Hay, J; Waldeck-Weiermair, M; Kratky, D; Madl, T; Malli, R; Graier, WFPresenilin-1 Established ER-Ca2+ Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells upon Elevated Glucose. Cell Physiol Biochem. 2019; 53(3): 573-586. Doi: 10.33594/000000158 OPEN ACCESS
Korbelius, M; Vujic, N; Sachdev, V; Obrowsky, S; Rainer, S; Gottschalk, B; Graier, WF; Kratky, DATGL/CGI-58-Dependent Hydrolysis of a Lipid Storage Pool in Murine Enterocytes. Cell Rep. 2019; 28(7): 1923-1934. Doi: 10.1016/j.celrep.2019.07.030 OPEN ACCESS
Madreiter-Sokolowski, CT; Malli, RM; Graier, WFMitochondrial-Endoplasmic Reticulum Interplay: A Lifelong On-Off Relationship? Contact (Thousand Oaks). 2019; 2: 2515256419861227-2515256419861227. Doi: 10.1177/2515256419861227 OPEN ACCESS
Madreiter-Sokolowski, CT; Waldeck-Weiermair, M; Bourguignon, MP; Villeneuve, N; Gottschalk, B; Klec, C; Stryeck, S; Radulovic, S; Parichatikanond, W; Frank, S; Madl, T; Malli, R; Graier, WFEnhanced inter-compartmental Ca2+ flux modulates mitochondrial metabolism and apoptotic threshold during aging.
Redox Biol. 2019; 20:458-466 Doi: 10.1016/j.redox.2018.11.003 OPEN ACCESS
Ramadani-Muja, J; Gottschalk, B; Pfeil, K; Burgstaller, S; Rauter, T; Bischof, H; Waldeck-Weiermair, M; Bugger, H; Graier, WF; Malli, RVisualization of Sirtuin 4 Distribution between Mitochondria and the Nucleus, Based on Bimolecular Fluorescence Self-Complementation. Cells. 2019; 8(12): Doi: 10.3390/cells8121583 OPEN ACCESS
Tiapko, O; Shrestha, N; Lindinger, S; Guedes de la Cruz, G; Graziani, A; Klec, C; Butorac, C; Graier, WF; Kubista, H; Freichel, M; Birnbaumer, L; Romanin, C; Glasnov, T; Groschner, KLipid-independent control of endothelial and neuronal TRPC3 channels by light. Chem Sci. 2019; 10(9):2837-2842 Doi: 10.1039/c8sc05536j OPEN ACCESS
Waldeck-Weiermair, M; Gottschalk, B; Madreiter-Sokolowski, CT; Ramadani-Muja, J; Ziomek, G; Klec, C; Burgstaller, S; Bischof, H; Depaoli, MR; Eroglu, E; Malli, R; Graier, WFDevelopment and Application of Sub-Mitochondrial Targeted Ca2 + Biosensors. Front Cell Neurosci. 2019; 13: 449-449. Doi: 10.3389/fncel.2019.00449 OPEN ACCESS
Bischof, H; Burgstaller, S; Waldeck-Weiermair, M; Rauter, T; Schinagl, M; Ramadani-Muja, J; Graier, WF; Malli, RLive-Cell Imaging of Physiologically Relevant Metal Ions Using Genetically Encoded FRET-Based Probes. Cells. 2019; 8(5): Doi: 10.3390/cells8050492 OPEN ACCESS
Depaoli, MR; Bischof, H; Eroglu, E; Burgstaller, S; Ramadani-Muja, J; Rauter, T; Schinagl, M; Waldeck-Weiermair, M; Hay, JC; Graier, WF; Malli, RLive cell imaging of signaling and metabolic activities. Pharmacol Ther. 2019; 202:98-119 Doi: 10.1016/j.pharmthera.2019.06.003 OPEN ACCESS
Depaoli, MR; Hay, JC; Graier, WF; Malli, RThe enigmatic ATP supply of the endoplasmic reticulum. Biol Rev Camb Philos Soc. 2019; 94(2):610-628 Doi: 10.1111/brv.12469 No InterWiki reference defined in properties for Wiki called "OPEN ACCESS\\
Klec, C; Ziomek, G; Pichler, M; Malli, R; Graier, WFCalcium Signaling in ß-cell Physiology and Pathology"!
Madreiter-Sokolowski, CT; Ramadani-Muja, J; Ziomek, G; Burgstaller, S; Bischof, H; Koshenov, Z; Gottschalk, B; Malli, R; Graier, WFTracking intra- and inter-organelle signaling of mitochondria.FEBS J. 2019; 286(22):4378-4401 Doi: 10.1111/febs.15103 OPEN ACCESS
Malli, R; Graier, WFIRE1α modulates ER and mitochondria crosstalk.
Nat Cell Biol. 2019; 21(6):667-668 Doi: 10.1038/s41556-019-0338-x
2018
Rockenfeller, P; Smolnig, M; Diessl, J; Bashir, M; Schmiedhofer, V; Knittelfelder, O; Ring, J; Franz, J; Foessl, I; Khan, MJ; Rost, R; Graier, WF; Kroemer, G; Zimmermann, A; Carmona-Gutierrez, D; Eisenberg, T; Büttner, S; Sigrist, SJ; Kühnlein, RP; Kohlwein, SD; Gourlay, CW; Madeo, FDiacylglycerol triggers Rim101 pathway-dependent necrosis in yeast: a model for lipotoxicity. Cell Death Differ. 2018; 25(4):767-783 Doi: 10.1038/s41418-017-0014-2
Depaoli, MR; Karsten, F; Madreiter-Sokolowski, CT; Klec, C; Gottschalk, B; Bischof, H; Eroglu, E; Waldeck-Weiermair, M; Simmen, T; Graier, WF; Malli, RReal-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells. Cell Rep. 2018; 25(2):501-512 Doi: 10.1016/j.celrep.2018.09.027
Deak, AT; Gottschalk, B; Eroglu, E; Rost, R; Waldeck-Weiermair, M; Graier, WF; Malli, RHigh-Resolution Imaging of STIM/Orai Subcellular Localization Using Array Confocal Laser Scanning Microscopy. Methods Mol Biol. 2018; 1843(2):175-187 Doi: 10.1007/978-1-4939-8704-7_15 Alkan, HF; Walter, KE; Luengo, A; Madreiter-Sokolowski, CT; Stryeck, S; Lau, AN; Al-Zoughbi, W; Lewis, CA; Thomas, CJ; Hoefler, G; Graier, WF; Madl, T; Vander Heiden, MG; Bogner-Strauss, JGCytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting. Cell Metab. 2018; 28(5):706-720 Doi: 10.1016/j.cmet.2018.07.021 Jain M, Stulic M, P. Rao SP, Kirsch A, Dieter Pullirsch D, Kristin Moreth K, Tanja Klein-Rodewald T, Bekeredjian R, Gailus-Durner V, Fuchs H, Hrab? de Angelis M, Graier WF, Maria Sibilia M, Frank S & Jantsch MF. RNA editing of filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure. EMBO J. 37(19):e94813, 2018. (10.15252/embj.201694813)
Eroglu E, Bischof H, Charoensin S, Waldeck-Weiermaier M, Graier WF, Malli R. Real-Time Imaging of Nitric Oxide Signals in Individual Cells Using geNOps. Methods Mol Biol. 1747:23-34, 2018. (doi: 10.1007/978-1-4939-7695-9_3) Fulltext PubMed
Corina T. Madreiter-Sokolowski, C.T., Sokolowski, A.A., Waldeck-Weiermair, M., Malli, R. & Graier, W.F. Targeting mitochondria to counteract age-related cellular dysfunction. Genes Epub ahead of print, 2018 (doi: 10.3390/genes9030165 ) Fulltext PubMed (Review)
Gottschalk, B., Christinae Klec, C., Waldeck-Weiermair, M., Malli, R. & Graier, W.F. Intracellular Ca2+ release decelerates mitochondrial cristae dynamics within the junctions to the endoplasmic reticulum. Pflügers Arch - Eur J Physiol 470(8):1193-1203, 2018 (doi: 10.1007/s00424-018-2133-0) Fulltext PubMed
Eroglu, E., Charoensin, S., Bischof, H., Ramadani, J., Gottschalk, B., Depaoli, M.R., Waldeck-Weiermair, M., Graier, W.F. & Malli, R. Genetic Biosensors for Imaging Nitric Oxide in Single Cells. Free Radical Biology and Medicine Epub ahead of print, 2018 (doi: 10.1016/j.freeradbiomed.2018.01.027) Fulltext PubMed (Review)
Duta-Mare, M., Sachdev, V., Leopold, C., Kolb, D., Vujic, N., Korbelius, M., Hofer, D.C., Xia, W., Huber, K., Auer, M., Gottschalk, B., Magnes, C., Graier, W.F., Prokesch, A., Radovic, B., Bogner-Strauss, J.G. & Kratky, D. Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis. BBA - Molecular and Cell Biology of Lipids 1863: 467-478, 2018 (doi: 10.1016/j.bbalip.2018.01.011) Fulltext PubMed
Opelt, M., Wolkart, G., Eroglu, E., Waldeck-Weiermair, M., Malli, R., Graier, W.F., Kollau, A., Fassett, J.T., Schrammel, A., Mayer, B. & Gorren, A.C.F. Sustained Formation of Nitroglycerin-Derived Nitric Oxide by Aldehyde Dehydrogenase-2 in Vascular Smooth Muscle Without Added Reductants. Implications for the Development of Nitrate Tolerance. Molec. Pharmacol. 93: 335-343, 2018 (doi: 10.1124/mol.117.110783 ) Fulltext PubMed
Bernhart, E., Kogelnik, N., Pratsch, J., Gottschalk, B., Göritzer, M., Deapoli, M.R., Reicher, H., Nusshold, C., Plastira, I., Hammer, A., Fauler, G. Malli, R., Graier, W.F., Malle, E., & Staller, W. Chlorohexadecanoic acid induces ER stress and mitochondrial dysfunction in brain microvascular endothelial cells. Redox Biology 15: 441-451, 2018 (doi: 10.1016/j.redox.2018.01.003) Fulltext PubMed
Madreiter-Sokolowski, C.T. & Graier, W.F. Manipulation of mitochondrial function by polyphenols as key for new treatment strategies. Polyphenol Book (in press), 2018 (doi:) Fulltext PubMed
2017
Plastira, I., Bernhart, E., Goeritzer, M., DeVaney, T., Reicher, H., Hammer, A., Lohberger, B., Wintersperger, A., Zucol, B., Graier, W.F., Kratky, D., Malle, E. & Sattler, W. Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglia phenotype. J. Neuroinflammation 14:253, 2017 (doi: 10.1186/s12974-017-1024-1) Fulltext PubMed
Rockenfeller,P., Diessl, J., Bashir, M., Muschett, V., Smolnig, M., Schmiedhofer, V., Knittelfelder, O., Ring, J., Franz, J., Foessl, I., Khan, M.J., Rost, R., Graier, W.F., Sepp Kohlwein, S.D., Kroemer, G., Zimmermann, A., Carmona-Gutierrez, D., Eisenberg, T., Büttner, S., Sigrist, S., Kühnlein, R., Gourlay, C. & Frank Madeo, F. Lipotoxicity is executed via a calcium/ calpain dependent necrosis pathway. Cell Death and Differentiation (in press), 2017 (doi: 10.1038/s41418-017-0014-2) Fulltext PubMed
Bischof, H., Rehberg, M., Stryeck, S., Artinger, K., Eroglu, E., Waldeck-Weiermair, M., Gottschalk. B., Rost, R., Deak, A.T., Niedrist, T., Vujic, N., Lindermuth, H., Prassl, P., Pelzmann, B., Groschner, K., Kratky, D., Eller, K., Rosenkranz, A.R., Madl, T., Plesnila, N., Graier, W.F. & Malli, R. Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo. Nat. Commun. 8:1422, 2017 (doi: 10.1038/s41467-017-01615-z) Fulltext PubMed
Madreiter-Sokolwoski, C.T. Sokolowski, A.A. & Graier, W.F. Dosis facit sanitatem - Concentration-dependent effects of resveratrol on mitochondria. Nutrients 9: 1117, 2017 (doi: 10.3390/nu9101117) Fulltext PubMed
Malli, R. & Graier, W.F. The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+ Entry. Adv Exp Med Biol. 993: 297-319, 2017 (doi: 10.1007/978-3-319-57732-6_16 ) Fulltext PubMed
Eroglu, E., Hallströmb, S., Bischof, H., Opelt, M., Schmidt, K., Mayer, B., Waldeck-Weiermair, M., Graier, W.F. & Malli, R. Real-time visualization of nitric oxide synthase activity in single cells. Nitric Oxide 70: 59-67, 2017, 2017 (doi: 10.1016/j.niox.2017.09.001) Fulltext PubMed
Madreiter-Sokolowski, C.T., Györffy, B., Klec, C., Sokolowski, A.A., Rost, R., Waldeck-Weiermair, M., Malli, R. & Graier, W.F. UCP2 and PRMT1 are key prognostic markers for lung carcinoma patients. Oncotarget 8: 80278-80285, 2017 (doi: 10.18632/oncotarget.20571) Fulltext PubMed
Graier, W.F. & Malli, R. Mitochondrial Calcium: a crucial hub for cancer cell metabolism? Trans Cancer Res. 6 (Suppl.7): S1124-S1127, 2017 (doi: 10.21037/tcr.2017.08.28) Fulltext PubMed
Bärnthaler, T., Maric, J., Platzer, W., Konya, V., Theiler, A., Hasenöhrl, C., Gottschalk, B., Trautmann, S., Schreiber, Y., Graier, W.F., Schicho, R., Marsche, G., Olschewski, A., Thomas, D., Schuligoi, R. & Heinemann, A. The Role of PGE2 in Alveolar Epithelial and Lung Microvascular Endothelial Crosstalk. Sci. Rep. 7:7923, 2017 (doi: 10.1038/s41598-017-08228-y) Fulltext PubMed
Baker, D., Pryce, G., Visintin, C., Sisay, S., Bondarenko, A.I., Ho, W.S.V., Jackson, S.J., Williams, T.E., Al-Izki, S., Sevastou, I., Okuyama, M., Graier, W.F.,Stevenson, L.A., Tanner, C., Ross, R., Pertwee, R.G., Henstridge, C.M., Irving, A.J., Schulman, J., Powell, K., Baker, M.D., Giovannoni, G. & Selwood, D.L. Big conductance calcium-activated potassium channel openers control spasticity without sedation. Br. J. Pharmacol. 174: 2662-2681, 2017 Fulltext PubMed
Eroglu, E., Rost, R., Bischof, H., Blass, S., Schreilechner, A., Gottschalk, B., Deapoli, M.R., Klec, C., Charosin, S., Madreiter-Sokolowski, C.M., Waldeck-Weiermair, Graier, W.F. & Malli, R. Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for real-time imaging of NO• signals in single cells. JoVE 121, 2017 (doi: 10.3791/55486) Fulltext PubMed
Suphachai Charoensin, S., Emrah Eroglu, E., Opelt, M., Bischof, H., Madreiter-Sokolowski, C.T., Kirsch, A., Depaoli, M.R., Frank, S., Schrammel, A., Mayer, B., Waldeck-Weiermair, M., Graier, W.F. & Malli, R. Intact mitochondrial Ca2+ uniport is essential for agonist-induced activation of endothelial nitric oxide synthase (eNOS). Free Radical Biol Med 10: 248-259, 2017 (doi: 10.1016/j.freeradbiomed.2016.11.049) Fulltext PubMed
Hofer, D.C., Pessentheiner, A.R., Pelzmann, H.J., Schlager, S., Madreiter-Sokolowski, C.T., Kolb, D., Eichmann, T.O., Rechberger, G., Bilban, M., Graier, W.F., Kratky, D. & Bogner-Strauss, J.G. Critical role of the peroxisomal protein PEX16 in white adipocyte development and lipid homeostasis. BBA - Molecular and Cell Biology of Lipids 1862: 358-368, 2017 (doi: 10.1016/j.bbalip.2016.12.009 ) Fulltext PubMed
2016
Opelt, M., Eroglu, E., Waldeck-Weiermair, M., Russwurm, M., Koesling, D., Malli, R., Graier, W.F., Fassett, J.T., Schrammel, A. & Mayer, M. Formation of nitric oxide by aldehyde dehydrogenase-2 is necessary and sufficient for vascular bioactivation of nitroglycerin. J- Biol. Chem. 291: 24076-24074, 2016 (doi:10.1074/jbc.M116.75207) Fulltext PubMed
Madreiter-Sokolowski, C.T., Klec, C., Parichatikanond, W., , Stryeck, S., Gottschalk, B., Pulido, S., Rost, R., Eroglu, E., Hofmann, N.A., Bondarenko, A.I., Madl, T., Waldeck-Weiermair, M., Malli, R. & Graier, W.F. PRMT1-mediated methylation of MICU1 determines the UCP2/3-dependency of mitochondrial Ca2+ uptake in immortalized cells. Nat. Commun. 7:12897, 2016 (doi:10.1038/ncomms12897) Fulltext Pubmed
Madreiter-Sokolowski, C.T., Gottschalk, B., Parichatikanond, W., Eroglu, E., Klec, C., Waldeck-Weiermair, M., Malli, R. & Graier, W.F. Resveratrol specifically kills cancer cells by a devastating increase in the Ca2+ coupling between the greatly tethered endoplasmic reticulum and mitochondria. Cell. Physiol. Biochem. 39: 1404-1420, 2016 (doi:10.1159/000447844) Fulltext PubMed 39: 1404-1420, 2016 (doi:10.1159/000447844)
Malli, R., Eroglu, E., Waldeck-Weiermair, M. & Graier, W.F. Filling a GAP—An Optimized Probe for ER Ca2+ Imaging In Vivo (Preview). Cell Chemical Biology 23: 641-643, 2016 (doi:10.1016/j.chembiol.2016.06.003) Fulltext PubMed
Vinod, M., Patankar, J.V., Sachdev, V., Frank, S., Graier, W.F., Kratky, D. & Kostner, G.M. MiR-206 is Expressed in Pancreatic Islets and Regulates Glucokinase Activity. AJP - Endocrinology and Metabolism 311: E175-E185, 2016 (doi:10.1152/ajpendo.00510.2015) Fulltext PubMed
Radovi, B., Vuji, N., Leopold, C., Schlager, S., Goeritzer, M., Patankar, J.V., Korbelius, M., Kolb, D., Reindl, J., Wegscheider, M., Tomin, T., Birner-Gruenberger, R., Schittmayer, M., Groschner, L., Magnes, C., Diwoky, C., Frank S., Steyrer, E., Du, H., Graier, W.F., Madl, T. & Kratky, D. Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice. Diabetologia 59: 1743-1752, 2016 (doi:10.1007/s00125-016-3968-6) Fulltext Pubmed
Prokesch, A., Pelzmann, H.J., Pessentheiner, A.R., Huber, K., Madreiter-Sokolowski, C.T., Drougard, A., Schittmayer, M., Kolb, D., Magnes, C., Trausinger, G., Graier, W.F., Birner-Grünberger, R., Pospisilik, J.A. & Bogner-Strauss, J.G. N-acetylaspartate catabolism determin es cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes. Sci. Rep. 6: 23723, 2016 (doi:10.1038/srep23723) Fulltext Pubmed
Eroglu, E., Gottschalk, B., Charoensin, S., Blass, S., Bischof, H., Rost, R., Madreiter-Sokolowski, C.T., Pelzmann, B., Bernhart, E., Sattler, W., Hallström, S., Malinski, T., Waldeck-Weiermair, M., Graier, W.F. & Malli, R. Development of novel FP-based probes for live-cell imaging of nitric oxide dynamics. Nat. Commun. 7: 10623, 2016 (doi:10.1038/ncomms10623) Fulltext Pubmed
See also: Research Highlights in Nature Methods 13: 288, 2016 Link
Vujic, N., Schlager, S., Eichmann, T.O., Madreiter-Sokolowski, C.T., Goeritzer, M., Rainer, S., Schauer, S., Rosenberger, A., Woelfler, A., Doddapattar, P., Zimmermann, R., Hoefler, G., Lass, A., Graier, W.F., Radovic, B. & Kratky, D. Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice. Atherosclerosis 244: 9-21, 2016 (doi:10.1016/j.atherosclerosis.2015.10.109) Fulltext Pubmed
2015
Waldeck-Weiermair, M., Malli, R., Parichatikanond, W., Gottschalk, B., Madreiter-Sokolowski, C.T., Klec, C., Rost, R. & Graier, W.F. Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca2+. Sci. Rep. 5: 15602, 2015 (doi: 10.1038/srep15602)
Bondarenko, A.I., Parichatikanond, W., Madreiter, C.T., Rost, R., Waldeck-Weiermair, M., Malli, R. & Graier, W.F.. UCP2 modulates single channel properties of a MCU-dependent Ca2+ inward current in mitochondria. Pflügers Arch. – Eur. J. Physiol. 467: 2509-25018, 2015 (doi: 10.1007/s00424-015-1727-z)
Goeritzer, M., Vujic, N., Schlager, S., Chandak, P.G., Korbelius, M., Gottschalk, B., Leopold C., Obrowsky, S., Rainer, S.,Doddapattar, P., Aflaki, E., Wegscheider, M., Sachdev, V., Graier, W.F.,Kolb, D., Radovic, B. & Kratky, D. Active autophagy but not lipophagy in macrophages with defective lipolysis. BBA - Molecular and Cell Biology of Lipids 1851: 1304-1316, 2015 (doi: 10.1016/j.bbalip.2015.06.005)
Waldeck-Weiermair, M., Bischof, H., Blass, S., Deak, A., Klec, C., Graier, T., Roller, C., Rost, R., Eroglu, E., Gottschalk, B., Hofmann, N., Graier, W.F. & Malli, R. Generation of red-shifted cameleons for imaging Ca2+ dynamics of the endoplasmic reticulum. Biosensors 15: 13052-13068, 2015 (doi: 10.3390/s150613052)
Hofmann, N.A., Yang, J., Trauger, S.A., Nakayama, H., Huang, L., Strunk, D., Moses, M.A., Klagsbrun, M., Bischoff, J. & Graier, W.F. The G-protein coupled receptor 55-agonist L-alpha-lysophosphatidylinositol mediates ovarian carcinoma cell induced angiogenesis. Br. J. Pharmacol. 172: 4107-4118, 2015 doi: 10.1111/bph.13196)
Deak, A.T., Jean-Quartier, C., Bondarenko, A.I., Groschner, L.N., Malli, R., Graier, W.F. & Waldeck-Weiermair, M. Assessment of mitochondrial Ca²? uptake. Methods Mol. Biol.1264: 421-439, 2015 (doi: 10.1007/978-1-4939-2257-4_35)
2014
Kozina, A., Opresnik, S., Wong, M.S.K., Hallström, S., Graier, W.F., Malli, R., Schröder, K., Schmidt, K. & Frank, S. Oleoyl-lysophosphatidylcholine limits endothelial nitric oxide bioavailability by induction of reactive oxygen species. PLOSone 9: e113443, 2014 (doi:10.1371/journal.pone.0113443) Goeritzer, M., Schlager, S., Radovic, B., Madreiter, C., Rainer, S., Thomas, G., Lord, C.C., Sacks, J., Brown, A.L., Vujic, N., Obrowsky, S., Sachdev, V., Kolb, D., Chandak, P.G., Graier, W.F., Sattler, W., Brown, J.M. & Kratky, D. J. Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis. Lipid. Res. 55: 2562-2575, 2014 (doi: 10.1194/jlr.M052613 )
Hofmann, N.A., Barth, S., Waldeck-Weiermair, M., Klec, C., Strunk, D., Malli, R. & Graier, W.F. TRPV1 mediates cellular uptake of anandamide and thus promotes endothelial cell proliferation and network-formation. Biology Open 3: 1164–1172, 2014 (doi:10.1242/bio.20149571)
Rossmann, C., Windpassinger, C., Jud, D., Kovacevic, A., Schweighofer, N., Malli, R., Schuligoi, R., Prokesch, A., Kluve-Beckermann, Graier, W.F., Koyani, C.N., Kratky, D., Sattler, W. & Malle, E. Rat serum amyloid A4 (SAA4): Identification of a novel member of the SAA superfamily. Biochem. Biophys. Res. Commun. 450: 1643-1649, 2014 (doi: 10.1016/j.bbrc.2014.07.054)
Deak, A.T., Jean-Quartier, C., Bondarenko, A.I., Groschner, L.N., Malli, R., Graier, W.F. & Waldeck-Weiermair, M. Assessment of mitochondrial Ca2+ uptake. In: Mitochondrial Medicine: Methods and Protocols; Methods in Molecular Biology, Humana Press/Springer Group (USA) (in press) 2014
Kennedy, B.E., Madreiter, C.T., Vishnu, N., Malli, R.,Graier, W.F. & Karten, B. Adaptations of Energy Metabolism Associated with Increased Levels of Mitochondrial Cholesterol in Niemann-Pick Type C1-deficient Cells. J. Biol. Chem. 289: 16278-16289, 2014 (doi:10.1074/jbc.M114.559914 )
Deak, A.T., Blass, S., Khan, M.J., Groschner, L.N., Waldeck-Weiermair, M., Hallström, S., Graier, W.F. & Malli, R. Inositol-1,4,5-trisphosphate (IP3)-mediated STIM1 oligomerization requires intact mitochondrial Ca2+ uptake. J. Cell. Sci. 127: 2944-2955, 2014 (doi: 10.1242/?jcs.149807)
Vinod, M., Chennamsetty, I., Colin, S., De Paoli, F., Belloy, L., Schaider, H., Frank, S., Graier, W.F., Kratky, D., Staels, B., Chinetti-Gbaguidi, G. & Kostner, G.M. MIR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages. BBA - Molecular and Cell Biology of Lipids 1841: 827-833, 2014 (doi: 10.1016/j.bbalip.2014.02.006)
Groschner, L.N., Alam, M.R. & Graier, W.F. Metabolism-secreion coupling and mitochondrial calcium activities in clonal pancreatic beta-cells. Vitam. Horm. 95: 63-86, 2014 (doi: 10.1016/B978-0-12-800174-5.00003-X) Vishnu, N., Khan, M.J., Karsten, F., Groschner, L.N., Waldeck-Weiermair, M., Rost, R., Hallström, S., Imamura, H., Graier, W.F. & Malli, R. ATP Increases within the Lumen of the Endoplasmic Reticulum Upon Intracellular Ca2+-Release. Mol. Biol. Cell. 25: 368-379, 2014 (doi: 10.1091/mbc.E13-07-0433)
Bondarenko, A.I., Jean-Quartier, C., Parichatikanond, W., Alam, M.R., Waldeck-Weiermair, M., Malli, R., & Graier, W.F. Mitochondrial Ca2+ uniporter (MCU) -dependent and -independent Ca2+ channels coexist in the inner mitochondrial membrane. Pflügers Arch. – Eur. J. Physiol. 466: 1411-1420, 2014
2013
Pessentheiner A.R., Pelzmann, H.J., Walenta, E., Schweiger, M., Groschner, L.N., Graier, W.F., Kolb, D., Uno, K., Miyazaki, T., Nitta, A., Rieder, D., Prokesch, A., & Bogner-Strauss, J.G. N-acetyltransferase 8-lik e accelerates lipid turn over and increases energy expenditure in brown adipocytes. J. Biol. Chem. 288. 36040-36051, 2013 (doi: 10.1074/jbc.M113.491324)
Schernthaner, M., Leitinger, G., Wolinski, H., Kohlwein, S.D., Reisinger, B., Barb, R.-A., Graier, W.F., Heitz, J., & Groschner, K. Enhanced Ca2+ entry and tyrosine phosphorylation mediate nanostructure-induced endothelial proliferation. Journal of Nanomaterials Article ID 251063, 2013
Rao, S., Riederer, M., Lechleitner, M., Hermansson, M., Desoye, G., Hallström, S., Graier, W.F. & Frank, S. Acyl chain-dependent effect of lysophosphatidylcholine on endothelium-dependent vasorelaxation PLOSone 8: e65155, 2013 (doi: 10.1371/journal.pone.0065155)
Waldeck-Weiermair, M., Deak, A.T., Groschner, L.N., Alam, M.R., Jean-Quartier, C., Malli, R. & Graier, W.F. Molecularly distinct routes of mitochondrial Ca2+ uptake are activated depending on the activity of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). J. Biol. Chem. 288: 15367-15379, 2013 (doi: 10.1074/jbc.M113.462259)
Bondarenko, A.i., Drachuk, K., Panasiuk, O., Sagach, V., Deak, A., Malli, R. & Graier, W.F. N-arachidonoyl glycine suppresses Na+/Ca2+ exchanger-mediated Ca2+ entry into endothelial cells and activates BKCa channels independently of G-protein coupled receptors. Br. J. Pharmacol. 169: 933-948, 2013 (doi: 10.1111/bph.12180)
Bondarenko, A.I., Jean-Quartier, C., Malli, R. & Graier, W.F. Characterization of distinct single channel properties of Ca2+ inward currents in mitochondria. Pflügers Arch. – Eur. J. Physiol. 465: 997-1010, 2013 (doi: 10.1007/s00424-013-1224-1)
Deak, A.T., Groschner, L.N., Alam, M.R., Seles, E., Bondarenko, A.I., Graier, W.F. & Malli, R. The endocannabinoid N-arachidonoyl glycine (NAGly) inhibits store-operated Ca2+ entry by preventing STIM1/Orai1 interaction. J. Cell. Sci.126: 879-888, 2013 (doi: 10.1242/jcs.118075)
2012 Waldeck-Weiermair, M., Alam, M.R., Khan, M.J., Deak, A., Vishnu, N., Karsten, F., Imamura, H., Graier, W.F. & Malli, R. Spatiotemporal correlations between cytosolic and mitochondrial Ca2+ signals using a novel red-shifted mitochondrial targeted cameleon. PLOSone 7(9): e45917, 2012 Fulltext PudMed
Alam, M.R. Groschner, L.N., Parichatikanond, W., Kuo, L., Bondarenko,A.I., Rost, R., Waldeck-Weiermair, M., Malli, R. & Graier, W.F. Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial Ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic ß-cells. J. Biol. Chem. 287: 34445-34454, 2012 Fulltext PudMed
Brkic, L., Riederer, M., Graier, W.F., Malli, R. & Frank, S. Acyl chain-dependent effect of lysophosphatidylcholine on Ca2+-dependent expression of cyclooxygenase (COX)-2 in endothelial cells. Atherosclerosis 224: 348-354, 2012 Fulltext PudMed
Willer, E.A., Malli, R., Bondarenko, A.I., Zahler, S., Vollmar, A.M., Graier, W.F. & Fürst, R. The vascular barrier-protecting hawthorn extract WS® 1442 raises endothelial calcium levels by inhibition of SERCA and activation of the IP3 pathway. Journal of Molecular and Cellular Cardiology 53: 597-577, 2012 Fulltext Pubmed
Khan, M.J., Alam, M.R., Waldeck-Weiermair, M., Karsten, F., Groschner, L., Riederer, M., Hallstroem, S., Rockenfeller, P., Konya, V., Heinemann, A., Madeo, F., Graier, W.F., & Malli, R.. Inhibition of autophagy rescues palmitic acid induced necroptosis of endothelial cells. Journal of Biological Chemistry 287: 21110-21120, 2012 Fulltext Pubmed
Crnkovic, S., Riederer, M., Lechleitner, M., Hallström, S., Malli, R., Graier, W.F., Jörg Lindenmann, J., Popper, H., Olschewski, H., Olschewski, A. & Frank, S. Docosahexaenoic acid-induced unfolded protein response, cell cycle arrest and apoptosis in vascular smooth muscle cells are triggered by Ca2+-dependent induction of oxidative stress. Free Radical Biology & Medicine 52: 1786-1795, 2012 Fulltext Pubmed
Groschner, L.N., Waldeck-Weiermair, M., Malli, R. & Graier, W.F. Endothelial mitochondria less respiration, more integration. Pflügers Arch. Eur. J. Physiol. 646: 63-76, 2012 Fulltext Pubmed
Aflaki, E., Doddapattar, P., Radovic, B., Vujic, N., Wegscheider, M., Povoden, S., Koefeler, H., Graier, W.F., Malli, R., Kolb, D., Madeo, F., & Kratky, D. C16 ceramide is crucial for apoptosis in adipose triglyceride lipase-deficient macrophages. Cell Death and Disease 3: e280, 2012 Fulltext Pubmed
Book: Store-operated Ca2+ entry (SOCE) pathways. Eds. Klaus Groschner, Wolfgang F. Graier & Christoph Romanin by Springer 2012 Link
Jean-Quartier, J., Bondarenko, A.I., Alam, M.R., Trenker, M., Waldeck-Weiermair, M., Malli, R., & Graier, W.F. Studying mitochondrial Ca2+ uptake - a revisit. Molecular and Cellular Endocrinology 353: 114-127, 2012 Fulltext Pubmed
Malli, R. & Graier, W.F. The contribution of distinct mitochondrial Ca2+ uptake mechanisms, mitochondrial motility and location to store-operated Ca2+ entry. In: Store-operated Ca2+ entry (SOCE) pathways. Eds. Klaus Groschner, Wolfgang F. Graier & Christoph Romanin by Springer, Chapter 15, pg. 211-230, 2012 Link
2011
Waldeck-Weiermair, M., Jean-Quartier, C., Rost, R., Khan, M.J., Vishnu, N., Bondarenko, A.I., Imamura, H., Malli, R. & Graier, W.F. The leucine zipper EF hand-containing transmembrane protein 1 (LETM1) and uncoupling proteins- 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways. J. Biol. Chem. 286: 28444-28455, 2011 Fulltext Pubmed
Bondarenko, A.I., Malli, R. & Graier, W.F. The GPR55 agonist lysophosphatidylinositol directly activates intermediate conductance Ca2+ activated K+ channels. Pflügers Arch. - Eur. J. Physiol. 462: 245–255, 2011 Fulltext Pubmed
Bondarenko, A.I., Malli, R. & Graier, W.F. The GPR55 agonist lysophosphatidylinositol acts as an intracellular messenger and bidirectionally modulates Ca2+-activated large-conductance K+ channels in endothelial cells. Pflügers Arch. - Eur. J. Physiol. 461: 177-189, 2011 Fulltext Pubmed
Aflaki, E., Radovic, B., Chandak, P.G., Kolb, D., Eisenberg, T., Ring, J., Fertschai, I., Uellen, A., Wolinski, H., Kohlwein, S.D., Zechner, R., Levak-Frank, S., Sattler, W., Graier, W.F., Malli, R., Madeo, F. & Kratky D. Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages. J.Biol. Chem. 286: 7418-7428, 2011 Fulltext Pubmed
2010
Waldeck-Weiermair, M., Duan, X., Naghdi, S., Khan, M.J., Trenker, M., Malli, R. & Graier, W.F. Uncoupling protein 3 adjusts mitochondrial Ca2+ uptake to high and low Ca2+ signals. Cell Calcium 48: 288-301, 2010 free Fulltext Pubmed doi:10.1016/j.ceca.2010.10.004
Riederer , M., Ojala; P.J., Hrzenjak, A., Graier, W.F., Malli, R., Tritscher, M., Hermansson, M., Watzer, B., Schweer, H., Desoye, G., Heinemann, A. & Frank, S. Acyl chain-dependent effect of lysophosphatidylcholine on endothelial prostacyclin production. J. Lipid. Res. 51: 2957-2966, 2010 Fulltext Pubmed
Naghdi, S., Waldeck-Weiermair, M., Fertschai, I., Poteser, M., Graier, W.F. & Malli, R. Mitochondrial Ca2+ uptake and not mitochondrial motility is required for STIM1/Orai1-dependent store-operated Ca2+ entry. J. Cell Sci. 123: 2553-2564, 2010 Fulltext PubMed
Waldeck-Weiermair, M., Malli, R., Naghdi, S.,Trenker, M., Kahn, M.J. & Graier, W.F. The contribution of UCP2 and UCP3 to mitochondrial Ca2+ uptake is differentially determined by the source of supplied Ca2+. Cell Calcium 47: 433-440, 2010 (doi:10.1016/j.ceca.2010.03.004) Fulltext PubMed
Bondarenko, A., Waldeck-Weiermair, M., Naghdi, S., Poteser, M., Malli, R. & Graier, W.F. G-protein coupled receptor 55-dependent and -independent ion signaling in response to lysophosphatidylinositol in endothelial cells. Br. J. Pharmacol. 161: 308-320, 2010 free Fulltext PubMed -> download PDF
Schmidt, K. Martens-Lobenhoffer, J., Meinitzer, A., Graier, W.F., Torres, C.M., Venema, R.C. & Mayer, B. Activation of endothelial nitric oxide synthase by the pro-apoptotic drug embelin: striking discripancy between nitric oxide-mediated cyclic GMP accumulation and L-citrulline formation. Nitric Oxide 22: 281-289, 2010 Fulltext PubMed
Bentley, M., Nycz, D., Joglekar, A., Fertschai, I., Malli, R., Graier, W.F. & Hay, J.C. Vesicular calcium regulates coat retention, fusogenicity and size of pre-golgi intermediates. Molecular Biology of the Cell 21: 1033-1046, 2010 Fulltext PubMed
Malli, R. & Graier, W.F. Mitochondrial Ca2+ Channels: Great Unknowns with Important Functions. FEBS Lett. 584: 1942-1947, 2010 Fulltext PubMed
Bernhart, E., Kollroser, M., Rechberger, G., Reicher, H., Heinemann, A., Schratl, P., Hallstroem, S., Wintersperger, A., Nusshold, C.. DeVane T., Zorn-Pauly, K., Malli, R., Graier, W., Malle, E., and Sattler, W. Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture. Proteomics 10: 141-158, 2010 Fulltext PubMed
2009
Graier, W.F., Malli, R. and Kostner, G.M. Mitochondrial protein phosphorylation: Instigator or target of lipotoxicity? Trends in Endocrinology and Metabolism 20: 186-193, 2009 (Review) Fulltext PubMed
2008
Trenker, M., Fertschai, I., Malli, R. and Graier, W.F. UCP2/3 – Likely to be fundamental for mitochondrial Ca2+ uniport. Nat. Cell. Biol. 10: 1237-1240, 2008 (Correspondence; doi:10.1038/ncb1108-1237) Fulltext PubMed
Graier, W.F. and Hecker, M. Endothelial H2O2: a bad guy turing good? Arteriosler. Thromb. Vasc. Biol. 28: 1696-1698, 2008 (doi:10.1161/ATVBAHA.108.173963; Editorial) Fulltext PubMed
Malli, R., Shamim Naghdi, S., Romanin, C. and Graier, W.F. Cytosolic Ca2+ prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca2+ overload. J. Cell. Sci. 121: 3133-3139, 2008 (doi:10.1242/jcs.034496) Fulltext PubMed
Jousset, H., Malli, R., Girardin, N.C., Graier, W.F., Demaurex, N. and M. Frieden, M. Evidence for a receptor-activated Ca2+ entry pathway independent from Ca2+ store depletion in endothelial cells. Cell Calcium 43: 83-94, 2008 Fulltext PubMed
Graier, W.F., Trenker, M. and Malli, R. Mitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3? Cell Calcium 44: 36-50, 2008 (doi: 10.1016/j.ceca.2008.01.001; Review) Fulltext PubMed
Waldeck-Weiermair, M., Zoratti, C., Osibow, K., Balenga, N., Goessnitzer, E., Waldhoer, M., Malli, R. and Graier, W.F. Integrin-clustering enables endocannabinoid-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor triggered repression. J. Cell. Sci. 121: 1704-1717, 2008 (doi: 10.1242/jcs.020958) Fulltext PubMed
Schweiger, M., Schoiswohl, G., Lass, A., Radner, F.P.W., Haemmerle, G., Malli, R., Graier, W.F., Cornaciu, I., Oberer, M., Salvayre, R., Fischer, J., Zechner, R. and Zimmermann, R. The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding. J. Biol. Chem. 283: 17211-17220, 2008 (doi:10.1074/jbc.M710566200) Fulltext PubMed
2007
Malli, R., Frieden, M., Hunkova, M., Trenker, M. and Graier, W.F.Ca2+ refilling of the endoplasmic reticulum is largely preserved albeit reduced Ca2+ entry in endothelial cells. Cell Calcium 41: 63-76, 2007 Fulltext PubMed
Trenker, M., Malli, R., Fertschai, I., Levak-Frank, S., and Graier, W.F. Uncoupling-proteins 2 and 3 are elementary for mitochondrial Ca2+ uniport. Nat. Cell. Biol. 9: 445-452, 2007, doi:10.1038/ncb1556 Fulltext PubMed
Graier, W.F., Frieden, M. and Malli, R. Mitochondria and Ca2+ signaling: old guests, new functions. Pflügers Archiv - European Journal of Physiology 455: 375-396, 2007 (Review) Fulltext PubMed
Wiesenberger, G., Steinleitner, K., Malli, R., Graier, W.F., Schweyen, R.J. and Stadler, J.A. Mg2+ deprivation elicits rapid Ca2+ uptake and activates Ca2+/calcineurin signaling in Saccharomyces cerevisiae. Eucarytotic Cell 6: 592-599, 2007, doi:10.1128/EC.00382-06 Fulltext PubMed
2006
Osibow, K., Frank, S., Malli, R., Zechner, R. and Graier, W.F. Mitochondria maintain maturation and secretion of lipoprotein lipase in the endoplasmic reticulum. Biochem. J. 396: 173-182, 2006. Fulltext PubMed
Osibow, K., Malli, R., Kostner, G.M. and Graier, W.F. A new type of non-Ca2+ -buffering apo(a)-based fluorescent indicator for intraluminal Ca2+ in the endoplasmic reticulum. J. Biol. Chem. 281: 5017-5025, 2006 Fulltext PubMed
2005
Kipmen-Korgun, D., Osibow, K., Zoratti, C., Schraml, E., Greilberger, J., Kostner, Juergens, G. and Graier, W.F. T-cadherin mediates low-density lipoprotein-initiated cell proliferation via the Ca2+-tyrosine kinase-Erk1/2 pathway. J. Cardiovasc. Pharmacol. 45: 418-430, 2005 Fulltext PubMed
Malli, R, Frieden, M., Trenker, M. and Graier, W.F. The role of mitochondria for Ca2+ refilling of the ER. J. Biol. Chem. 280: 12114-12122, 2005 Fulltext PubMed
Knot, H.J., Laher, I., Sobie, E.A., Guatimosim, S., Gomez-Viquez, L., Hartmann, H., Song, L.-S., Lederer, W.J.,Graier, W.F., Malli, R., Frieden, M., and Petersen, O.H. Twenty years of calcium imaging: cell physiology to dye for. Molec. Interventions 5: 112-127, 2005 (Review) Fulltext PubMed
2004
Bilban, M., Ghaffari-Tabrizi, N., Hintermann, E., Bauer , S., Molzer, S., Zoratti, C., Malli, R., Sharabi, A., Hiden, U., Graier, W.F., Knöfler, M., Andreae, F., Wagner, O., Quaranta1, V. and Desoye, G. Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiologic invasion inhibitor of primary human trophoblasts. J Cell Sci 117:1319-1328, 2004
Graziani, A., Bricko, V. Wolfgang F. Graier, W.F. and Klaus Groschner. Cholesterol-and caveolin-rich membrane domains are essential for phospholipase A2-dependent EDHF formation. Cardiovasc Res. 64: 234-242, 2004
Paltauf-Doburzynska, J., Malli,R. and Graier, W.F. Hyperglycemic conditions affect shape and Ca2+ homeostasis of mitochondria in endothelial cells. J. Cardiovasc. Pharmacol. 44: 424-437, 2004
Marsche, G.,, Heller , R., Nuszkowsi , A., Fauler , G., Kovacevic, A., Graier, W.F., Sattler , W. and Malle, E. 2-Chlorohexadecanal, derived from hypochlorite-modified high-density lipoprotein-associated plasmalogen is a natural inhibitor of endothelial nitric oxide biosynthesis. Arteriosler. Thromb. Vasc. Biol. 24:2302-2306, 2004
2003
Schaeffer, G., Levak-Frank, S., Spitaler, M.M., Fleischhacker, E., Esenabhalu, V.E., Wagner, A.H., Hecker, M. and Graier, W.F. Intercellular signaling within vascular cells under high d-glucose involves free radical-triggered tyrosine kinase activation. Diabetologia 46: 773-783, 2003
Malli, R., Frieden, M., K. Osibow, K. and W.F. Graier, W.F. Mitochondria efficiently buffer subplasmalemmal Ca2+ elevation during agonist stimulation. J. Biol. Chem. 278: 10807-10815, 2003
Esenabhalu, V.E., Schaeffer, G. and Graier, W.F. Free fatty acid overload attenuates Ca2+ signaling and no production in endothelial cells. Antioxidants & Redox Signaling 5: 147-153, 2003
Artwohl, M., Graier, W.F., Roden, M., Bischof, M.,Freudenthaler, Waldhäusl, W.,A. and Baumgartner-Parzer, S.M. Diabetic low-density lipoprotein triggers apoptosis in vascular endothelial cells. Diabetes 52: 1240-1247, 2003
Zoratti, C., Kipmen-Korgun, D., Osibow, K., Malli, R. and Graier, W.F. Anandamide initiates Ca2+ signaling via CB2-receptor linked to phospholipase C in calf pulmonary endothelial cells. Br. J. Pharmacol. 140: 1351-1362, 2003
Malli, R., Frieden, M., Osibow, K., Mayer, M., Demaurex, N. and Graier, W.F. Sustained Ca2+ transfer across mitochondria is essential for mitochondrial Ca2+ buffering, store-operated Ca2+ entry, and Ca2+ store refilling. J. Biol. Chem. 278: 44769-44779, 2003
2002
Bochkov, V.N., Mechtcheriakova, D., Lucerna, M., Huber, J., Malli, R., Graier, W.F., Binder, B.R and Leitinger, N. Oxidized 1-palmitoyl-2-arachidonolyl-sn-glycero-3-phosphorylcholine (OxPAPC) stimulates expression of tissue factor in human endothelial cells through activation of erk/erg-1 and Ca2+/NFAT. Blood 99: 199-206, 2002
Esenabhalu, V.E., Cerimagic, M., Malli, R., Osibow, K., Levak-Frank, S., Frieden, M., Sattler, W., Kostner, G.M. Zechner, R. and Graier, W.F. Tissue specific expression of human lipoprotein lipase in the vacular system affects vascular reactivity in transgenic mice. Br. J. Pharmacol. 135: 143-154, 2002
Frieden, M., Malli, R., Samardzija, M., Demaurex, N. and Graier, W.F. Subplasmalemmal endoplasmic reticulum controls KCa channel activity upon stimulation with moderate histamine concentration in a human umbilical vein endothelial cell line. J. Physiol. 544: 73-84, 2002 (issue’s cover image).
Thyagarajan, B., Malli, R., Schmidt, K., Graier, W.F. and Groschner, K. Evidence for a pivotal role of mitochondria in regulation of capacitive Ca2+entry by nitric oxide. Br. J. Pharmacol. 137: 821-830, 2002
Spitaler, M.M. and Graier, W.F. Vascular targets of redox signalling in diabetes mellitus. Diabetologia 45: 476-494, 2002
Tiran, A., Gruber, H.J., Graier, W.F., Wagner, A.H., Wilders-Truschnig, M. and Tiran, B. Aspirin inhibits Chlamydia pneumoniae-induced NF-kB Activation, cytokine expression and Bacterial development in human endothelial cells. Arteriosler. Thromb. Vasc. Biol. 22:1075-1080, 2002
Spitaler, M., Hammer, A., Malli, R. and Graier, W.F. Functional analysis of histamine receptor subtypes involved in endothelial-mediated relaxation of the human uterine artery. Clin. Exp. Pharmacol. Physiol. 29: 211-216, 2002
2001
Schulter, V., Koolwijk, P., Peters, E., Frank, S., Hrzenjak, A., Graier, W.F., van Hingsbergh, V.W.M. and Kostner, G.M. The impact of apo(a) on in vitro angiogenesis. Arterioscler. Thromb. Vasc. Biol. 21:433-438, 2001
Zimmermann, R., Panzenböck, U., Wintersberger, Levak-Frank, S., Graier, W.F., Glatter, O., Fritz, G., Kostner, G.M. and Zechner, R. Lipoprotein lipase mediates the uptake of glycated low density lipoprotein in fibroblasts, endothelial cells, and macrophages. Diabetes 50: 1643-1653, 2001
Ugdyzhekova, D.S., Bernatskaya, N.A., Stefano, J.B., Graier, V.F., Tam, S.W., Mekhoulam, R. Endogenous cannabinoid anandamide increases heart resistance to arrhythmogenic effects of epinephrine: role of cb1 and cb2 receptors. Bull. Exp. Biol. Med. 131:251-253, 2001
Bowles, D.K., Graier, W.F. and Sturek, M. Hydrogene peroxide activates Na+ dependent Ca2+ influx in coronary endothelial cells. Biochem. Biophys. Res. Commun. 287: 1134-1139, 2001
2000
Fleischhacker, E., Esenabhalu, V.E., Holzmann, S., Skrabal, F., Koidl, B., Kostner, G.M. and Graier, W.F. In human hypercholesterolemia increased reactivity of smooth muscle cells is due to altered subcellular Ca2+ distribution. Atherosclerosis 149: 33-42, 2000
Paltauf-Doburzynska, J., Frieden, M., Spitaler, M. and Graier, W.F.Histamine-induced Ca2+ oscillations in a human endothelial cell line depend on transmembrane ion flux, ryanodine receptor and SERCA. J. Physiol. Lond. 524: 701-713, 2000
Frieden, M. and Graier, W.F. Subplasmalemmal ryanodine-sensitive Ca2+ release contributes to KCa channel activation in a human umbilical vein endothelial cell line. J. Physiol. Lond. 524: 715-724, 2000
Prates, S., Hörl, G., Graier, W.F., Sattler, W., Zechner, R. and Steyrer, E. Intracellular distribution and mobilization of unesterified cholesterol in adipocytes. J. Cell. Sci. 113: 2977-2889, 2000
Lintschinger, B., Balzer-Geldsetzer, M., Baskaran, T., Graier, W.F., Romanin, C. Zhu, M.X. and Groschner, K. Coassembly of Trp1 and Trp3 channels generates diacylglycerol and Ca2+ sensitive cation channels. J. Biol Chem. 275:27799-27805, 2000
1999
Posch, K., Schmidt, K. and Graier, W.F. Shear stress selectively stimulates uptake of L-arginine in endothelial cells - A mechanism essential for shearstress-mediated formation of nitric oxide. Life Sci. 64: 663-670, 1999
Schaeffer, G., Wascher, T.C., Kostner, G.M. and Graier, W.F. Alterations in platelet Ca2+ signaling in diabetic patients is due to increased formation of superoxide anions and reduced nitric oxide production. Diabetologia 42: 167-176, 1999
Fleischhacker, E., Esenabhalu, V.E., Spitaler, M., Holzmann, S., Skrabal, F., Koidl, B., Kostner, G.M. and Graier, W.F. Human diabetes mellitus is associated with hyperreactivity of vascular smooth muscle cells due to altered subcellular Ca2+ distribution. Diabetes 48:1323-1330, 1999
Mombouli, J.V., Holzmann, S., Kostner, G.M. and Graier, W.F. Potentiation of endothelial Ca2+ signaling by 11,12-epoxyeicosatrienoic acid. J. Cardiovasc. Pharmacol. 33: 779-784, 1999
Mombouli, J.V., Schaeffer, G., Holzmann, S.,Kostner, G.M. and Graier, W.F. Anandamide-induced mobilization of cytosolic Ca2+ in endothelial cells. Br. J. Pharmacol. 126: 1593-1600, 1999
Posch, K., Wascher, T.C., Baumgartner-Parzer, S., Kostner, G.M. and Graier, W.F. Glycated low-density lipoprotein attenuates shear stress-induced nitric oxide synthesis by inhibition of shear stress activated L-arginine uptake in endothelial cells. Diabetes 48:1331-1337, 1999
Paltauf-Doburzynska, J., Frieden, M. and Graier, W.F. Mechanisms of Ca2+ store depletion in single endothelial cells in a Ca2+-free environment. Cell Calcium 25: 345-353, 1999
Graier, W.F., Posch, K., Fleischhacker, E., Wascher, T.C. and Kostner, G.M.Increased superoxide anion formation in endothelial cells during hyperglycemia - An adaptive response or initial step of vascular dysfunction? Diab. Res. Clin. Pract. 45: 153-160, 1999
1998
Graier, W.F., Paltauf-Doburzynska, J., Hill, B., Fleischhacker, E., Hoebel, B.G., Kostner, G.M. and Sturek, S. Submaximal stimulation of porcine endothelial cells causes focal Ca2+ elevation beneath the cell membrane. J. Physiol. Lond. 506: 109-125, 1998
Hoebel, B.G. and Graier, W.F. 11,12-Epoxyeicosatrienoic acid stimulates tyrosine kinase activity in porcine aortic endothelial cells. Eur. J. Pharmacol. 346: 115-117, 1998
Graier, W.F., Hoebel, B.G., Paltauf-Doburzynska, J. and Kostner, G.M. Effects of Superoxide Anions on Endothelial Ca2+ Signaling Pathways. Arteriosler. Thromb. Vasc. Biol. 18: 1470-1479, 1998
Paltauf-Doburzynska, J., Posch, K., Paltauf, G. and Graier, W.F. Stealth ryanodine-sensitive Ca2+ release contributes to activity of capacitative Ca2+ entry and nitric oxide synthase in human and bovine endothelial cells. J. Physiol. Lond. 513: 369-379, 1998
Hoebel, B.G., Steyrer, E. and Graier, W.F. Origin and function of epoxyeicosa-trienoic acids in vascular endothelial cells - More than just endothelium-derived hyperpolarizing factor? Clin. Exp. Pharmacol. Physiol. 25: 826-830, 1998
1997
Paltauf-Doburyzenska, J. and Graier, W.F. Temperature-dependence of agonist-stimulated Ca2+ signaling in cultured endothelial ccells. Cell Calcium 21: 43-51, 1997
Graier, W.F., Simecek, S., Hoebel, B.G., Wascher, T.C., Dittrich, P and Kostner, G. Antioxidants prevent high D-glucose-enhanced endothelial Ca2+/cGMP response by scavanging superoxide anions. Eur. J. Pharmacol. 322: 113-121 1997
Wascher, T.C., Posch, K., Wallner, S., Hermetter, A., Kostner, G.M. and Graier, W.F. Vascular effects of L-arginine: anything beyond a substrate for the NO-synthase? Biochem. Biophys. Res. Commun. 234: 35-38, 1997
Wascher, T.C., Graier, W.F., Dittrich, P., Hussain, M.A., Bahadori, B., Habersack-Wallner, S.and Toplak, H. Effects of low-dose L-arginine on insulin-mediated vasodilation and insulin sensitivity. Eur. J. Clin. Invest. 26: 707-712, 1997
Hoebel, B.G., Kostner, G.M and Graier, W.F. Microsomal cytochrome P450 mono-oxygenase is activated by Ca2+ store depletion and contributes to Ca2+ entry in porcine aortic endothelial cells. Br. J. Pharmacol. 121: 1579-1588, 1997
Graier, W.F., Posch, K., Wascher, T.C., Kukovetz, W.R. and Kostner, G.M. Role of superoxide anions in change of endothelial vasoactive response during acute hyperglycemia. Horm. Met. Res. 29: 622-629, 1997
Graier, W.F. and Kostner, G.M. Glycated LDL and atherosclerosis: The missing link between diabetes mellitus and hypercholesterolemia? Eur. J. Clin. Invest. 27: 457-459, 1997 (Editorial)
1996
He, G.-W., Yang, C.-Q., Graier, W.F. and Yang, J.-A.. Hyperkalemia alters EDHF-mediated hyperpolarization and relaxation in coronary arteries. Am. J. Physiol. 271: H760-H767, 1996
Wascher, T.C., Bachernegg, M., Kickenweiz, A., Stark, G., Stark, U., Toplak, H. and Graier. Involvement of the L-arginine-nitric oxide pathway in hyperglycemia-induced coronary artery dysfunction of ioslated guinea pig hearts. E. J. Clin. Invest. 26: 707-712, 1996
Graier, W.F., Simecek, S., Kukovetz, W.R. and Kostner, G.M. High D-glucose-induced changes in endothelial Ca2+/EDRF signaling is due to generation of superoxide anions. Diabetes 45: 1386-1395, 1996
Graier, W.F., Holzmann, S., Hoebel, B.G., Kukovetz, W.R. and Kostner, G.M. Mechanism of L-NG-nitroarginine/indomethacin-resitant relaxation in bovine and porcine coronary arteries. Br. J. Pharmacol. 119: 1177-1186, 1996
1995
Graier, W.F., Simecek, S., and Sturek, M. Cytochrome P450 mono-oxygenase-regulated signaling of Ca2+ entry in human and bovine endothelial cells. J. Physiol. Lond. 482: 259-274, 1995
Wascher, T.C., Bachernegg, M., Kickenweiz, A., Stark, G., Toplak, H., and Graier, W.F., Krejs, G.J. Elevation of D-glucose impairs coronary artery autoregulation under slight reduction of coronary flow. E. J. Clin. Invest. 25: 590-594, 1995
Graier, W.F., Grubenthal, I., Peter Dittrich, P., Thomas C. Wascher, T.C., Kostner, G.M. Intracellular mechanism of high D-glucose-induced modulation of vascular cell proliferation. Eur. J. Pharmacol. 294: 221-229, 1995
Brunner, F., Stessel, H., and Graier, W.F. The effects of intracellular Ca2+ concentration and hyopxia on basal endothelin-1 secretion by cultured bovine aortic endothelial cells. Agents Actions (Suppl.) 45:269-273, 1995
Toplak, H., Graier, W.F., Dittrich, P., Wiesmann, U.N. and Wascher, T.C. Insulin resistance and membrane abnormalties. Lancet 345: 995, 1995 (Letter)
1994
Holzmann, S., Kukovetz, W.R., Windischhofer, W., Paschke, E., and Graier, W.F. Pharmacological differentiation between EDRF- and EDHF-mediated relaxation of coronary arteries. J. Cardiovasc. Pharmacol. 23: 747-756, 1994
Wascher, T.C., Toplak, H., Krejs, G.J., Simecek, S., Kukovetz, W.R., and Graier, W.F. Intracellular mechanisms involved in D-glucose-mediated amplification of agonist-induced Ca2+ response and EDRF formation in vascular endothelial cells. Diabetes 43: 984-991, 1994
Graier, W.F., Simecek, S., Bowles, D.K. and Sturek, M. Heterogeneity of caffeine and bradykinin-sensitive stores in vascular endothelial cells.Biochem. J. 300: 637-641, 1994
Groschner, K., Graier, W.F. and Kukovetz, W.R. Histamine induces K+, Ca2+ and Cl- currents in human vascular endothelial cells - Role of ionic currents in stimulation of nitric oxide biosynthesis. Circ. Res. 75: 304-314, 1994
Graier, W.F., Myers, P.R., Rubin, L.J., Adams, H.R. and Parker, J.L. Escherichia coli endotoxin inhibits agonist-mediated cytosolic calcium mobilization and nitric oxide biosynthesis in cultured endothelial cells. Circ. Res. 75: 659-668, 1994
Brunner, F., Stessel, H., Simecek, S and Graier, W.F., and Kukovetz, W.R. Effect of intracellular Ca2+ concentration on endothelin-1 secretion. Febs Lett. 350: 33-36, 1994
Wascher, T.C., Toplak, H., Bahadori, B., Graier, W.F. and Krejs, G.J. Time course of endothelial dysfunction in diabetes mellitus. Circulation 90: 1109, 1994 (Letter)
Graier, W.F., Sturek, M., and Kukovetz, W.R. Ca2+ regulation and endothelial vascular function. Endothelium 1: 223-236, 1994. 1993
Graier, W.F., Groschner, K., and Kukovetz, W.R. cAMP enhances agonist-induced Ca2+ entry into endothlial cells by activation of potassium channels and membrane hyperpolarization. Biochem. J. 291:263-267, 1993
Graier, W.F., Wascher, T.C., Lackner, L., Toplak, H., Krejs, G.J., and Kukovetz, W.R. Prolonged exposure to elevated glucose concentrations modulates vascular endothelial cell vasodilatatory response. Diabetes 42: 1497-1505, 1993
1992
Graier, W.F., Schmidt, K., and Kukovetz, W.R. Is the bradykinin-induced Ca2+ influx and the formation of endothelium derived relaxing factor mediated by a G protein? European J. Pharmacol. - Molecular Pharmacology Section, 225: 43-49, 1992
Schmidt, K., Klatt, P., Graier, W.F., Kostner, G.M., and Kukovetz, W.R. High-density lipoprotein antagonizes the inhibitory effects of oxidized low-density lipoprotein and lysolecithin on soluble guanylyl cyclase. Biochem. Biophys. Res. Commun. 182: 302-308, 1992
Groschner, K., Graier, W.F., and Kukovetz, W.R. Activation of a small-conductance Ca2+-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells. Biochim. Biophys. Acta 1137: 162-170, 1992
Graier, W.F., Groschner, K., Schmidt, K., and Kukovetz, W.R. SK&F 96365 inhibits histamine-induced formation of endothelium-derived relaxing factor in human endothelial cells. Biochem. Biophys. Res. Commun. 186: 1539-1545, 1992
Graier, W.F., Groschner, K., Schmidt, K., and Kukovetz, W.R. Increases in endothelial cAMP levels amplify agonist-induced formation of endothelium-derived relaxing factor (EDRF). Biochem. J. 288: 345-349, 1992
Kukovetz, W.R., Graier, W.F., and Groschner, K. Contribution of agonist-induced hyperpolarization to Ca2+ influx and formation of EDRF in vascular endothelial cells. Jap. J. Pharmacol. 58 (Suppl.2): 213P-219P, 1992
1991
Schmidt, K., Graier, W.F., Kostner, G.M., Mayer, B., Böhme, E., and Kukovetz, W.R. Oxidized low-density lipoprotein antagonizes the stimulation of soluble guanylate cyclase by endothelium-derived relaxing factor. Cell. Signal. 3: 361-367, 1991
Graier, W.F., Schmidt, K., and Kukovetz, W.R. Bradykinin-induced Ca2+-influx into cultured endothelial cells is not regulated by inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate. Second Messengers and Phosphoproteins 13: 187-197, 1991
Graier, W.F., Schmidt, K., and Kukovetz, W.R. Activation of G-protein evokes Ca2+ -influx in endothelial cells without correlation to the formation of inositolphosphates. J. Cardiovasc. Pharmacol. 17 (Suppl.3) S71-S78, 1991
Schmidt, K., Graier, W.F., Kostner, G.M., Mayer, B., Böhme, E., and Kukovetz, W.R. Stimulation of soluble guanylate cyclase by EDRF is antagonized by oxidized low-density lipoprotein. J Cardiovasc Pharmacol 17 (Suppl.3) S83-S86, 1991
1990
Graier, W.F., Schmidt, K., and Kukovetz, W.R. Effect of sodium fluoride on cytosolic free Ca2+-concentration and cGMP-formation in endothelial cells. Cell. Signal. 2: 369-375, 1990
Schmidt, K., Graier, W.F., Kostner, G.M., Mayer, B., and Kukovetz, W.R. Activation of soluble guanylate cyclase by nitrovasodilators is inhibited by oxidized low-density lipoprotein. Biochem. Biophys. Res. Commun. 172: 614-619, 1990
Technical Notes:
Graier, W.F. and Malli, R. Novel live-cell dual excitation/dual emission imaging system for the simultaneous visualization of cytosolic Ca2+ signaltransduction processes and mitochondrial dynamics. International Labmate August 70-71, 2007 PDF
Proceedings:
Paltauf-Dobuzynska, J., Kohlwein, S.D. and Graier, W.F. Digital imaging of diabetic endothelial cells. Progress in biomedical optics and imaging 4260: 1-6, 2001
Graier, W.F. and Wascher, T.C. Zelluläre Grundlagen der Gefäßkomplikationen im Diabetes mellitus. Journal für Kardiologie 7: 9-13, 2000
Rubin, L.J., Adams, H.R., Myers, P.R., Graier, W.F. and Parker, J.L. Inhibition of endothelial cell NOS in sepsis and shock. Proceedings of the Third International Shock Congress, Hamamatsu, Japan. In: Excerpta Medica International Congress Series 1102. Elsevier Science, The Netherlands, 1996, pg. 25-36
Graier, W.F. Bedeutung und Rolle des endothelialen Relaxationsfaktors. ÖAZ 46 Jg (23): 457-459, 1992
Schmidt, K., und Graier, W.F. Stereoselektivität bei bioaktiven Substanzen - ein aktuelles Problemgebiet in Chemie und Biologie. ÖAZ 43 Jg. (39): 745-746, 1989
