Eero Kajantie - Selected Publications#

Total number of peer-reviewed original publications in international journals: 480. Citations: 30 703. Clarivate h index: 76.

1. Heikkilä K, Metsälä J, Pulakka A, Nilsen SM, Kivimäki M, Risnes K, KAJANTIE E. Preterm birth and the risk of multimorbidity in adolescence: a multiregister-based cohort study. LANCET PUBLIC HEALTH. 2023;8:e680-e690. IF 50.0. A register study using data for 1.7 million people from Finland and Norway highlighting up to 4-fold risks of complex chronic disease multimorbidity in adolescents born preterm.

2. Pulakka A, Risnes K, Metsälä J, Alenius S, Heikkilä K, Nilsen SM, Näsänen-Gilmore P, Haaramo P, Gissler M, Opdahl S, KAJANTIE E. Preterm birth and asthma and COPD in adulthood: A nationwide register study from two Nordic countries. EUR RESPIR J 2023;61:2201763. IF 33.801. The first observation of substantially (over 10-fold in high-risk groups) increased risk of chronic obstructive lung disease in adults born preterm.

3. Risnes K, Bilsteen JF, Brown P, Pulakka A, Andersen AN, Opdahl S, KAJANTIE E, Sandin S. Mortality Among Young Adults Born Preterm and Early Term in 4 Nordic Nations. JAMA NETW OPEN. 2021 Jan 4;4(1):e2032779. IF 13.8. Times cited: 58. Clarivate highly-cited paper. Co-senior author in the first study from a EU-funded Nordic register study collaboration I initiated, showing increasing young adult mortality with decreasing gestational age at birth, consistently in 4 Nordic countries.

4. Räikkönen K, Gissler M, KAJANTIE E. Associations between maternal antenatal corticosteroid treatment and mental and behavioral disorders in children. JAMA 2020;323:1924-1933. doi: 10.1001/jama.2020.3937. IF 51.273. Times cited: 144 (Clarivate highly-cited paper). A register study, using sibling analyses to account for familial confounding, showing increased risk of mental and behavioural disorders in children of mothers who received antenatal corticosteroids for imminent preterm birth. The paper has been widely noted and led to more cautious guidelines of antenatal corticosteroid treatment especially in late preterm birth.

5. Paalanne M, Vääräsmäki M, Mustaniemi S, Tikanmäki M, Wehkalampi K, Matinolli HM, Eriksson JG, Järvelin MR, Morin-Papunen L, KAJANTIE E. Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm. EUR J ENDOCRINOL 2021;185:279-288. IF 6.664. Adults born preterm have substantially reduced rates of reproduction, but the mechanisms remain poorly understood. The first observation of an endocrine trait (hyperandrogenaemia) that could serve as mechanism underlying observations of substantially decreased reproduction in adult women born preterm.

6. KAJANTIE E, Johnson S, Heinonen K, Anderson PJ, Wolke D, Evensen KAI, Räikkönen K, Darlow BA, van der Pal S, Indredavik M, Jaekel J, Hovi P, Morrison K, Verrips E, Doyle LW, APIC Adults Born Preterm International Collaboration. Common Core Assessments in follow-up studies of adults born preterm—Recommendation of the Adults Born Preterm International Collaboration. PAEDIATR PERINAT EPIDEMIOL 2021;35:371-387.An expert recommendation on methods in studies of adults born preterm, an initiative I have headed in the Adults Born Preterm International Collaboration.

7. Kaseva N, Vääräsmäki M, Sundvall J, Matinolli HM, Sipola M, Tikanmäki M, Heinonen K, Lano A, Wehkalampi K, Wolke D, Ruokonen A, Andersson S, Järvelin MR, Räikkönen K, Eriksson JG, KAJANTIE E. Gestational diabetes but not prepregnancy overweight predicts for cardiometabolic markers in offspring twenty years later. J CLIN ENDOCRINOL METAB 2019;104:2785-2795. This paper among the few clinical follow-up studies able to disentangle the adult outcomes of intrauterine exposure to maternal obesity and gestational diabetes.

8. Sipola-Leppänen M, Vääräsmäki M, Tikanmäki M, Matinolli HM, Miettola S, Hovi P, Wehkalampi K, Ruokonen A, Sundvall J, Pouta A, Eriksson JG, Järvelin MR, KAJANTIE E. Cardiometabolic risk factors in young adults born preterm. AM J EPIDEMIOL 2015;181:861-873. IF 4.975. Times cited: 161. Clarivate highly-cited paper. The first publication on ESTER preterm birth study I started to assess risk factors of non-communicable and mental disorders in the large group of young adults born moderately-late preterm, little studied at that time. This study found that the increased risk of metabolic syndrome is not limited to those born most immature but may be clinically significant (2.5-fold compared with term-borns) already in young adults born at 34-36 weeks.

9. Hovi P, Andersson S, Eriksson JG, Järvenpää AL, Strang-Karlsson S, Mäkitie O, KAJANTIE E. Glucose regulation in young adults with very low birth weight. N ENGL J MED 2007;356:2053-2063. Times cited: 391. The first paper from the Helsinki Study of Very Low Birth Weight Adults (HeSVA) I had initiated as young PI. It became a landmark study as the first observation of impaired glucose regulation among adults born preterm and alerted the research and clinical communities of non-communicable disease risks in this group.

10. Barker DJP, Osmond C, Forsén TJ, KAJANTIE E, Eriksson JG. Trajectories of growth among children who have coronary events as adults. N ENGL J MED 2005;353:1802-1809. Times cited: 1083. This widely cited paper from my postdoctoral period was one of the first observations demonstrating slow infant growth as risk factor of coronary events in adult life.