Carlos Martin - Selected Publications#

Web of Science ResearcherID A-7283-2008
TOTAL PUBLICATIONS 189
TOTAL TIMES CITED 10.616
H-INDEX 45

"MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies"White et al NPJ Vaccines 2021 Jan 4;6(1):4.

"Live attenuated TB vaccines representing the three modern M. tuberculosis lineages reveal that the Euro-American genetic background confers optimal vaccine potential"Perez et al EBioMedicine 2020 . Apr 28;55:102761.

"New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia". Tarancon, Raquel; Dominguez-Andres, Jorge; Uranga, Santiago; Ferreira, Anaisa, V; Groh, Laszlo A.; Domenech, Mirian; Gonzalez-Camacho, Fernando; Riksen, Niels P.; Aguilo, Nacho; Yuste, Jose; Martin, Carlos; Netea, Mihai G. Published:Apr 2020 in PLOS PathogensDOI: 10.1371/JOURNAL.PPAT.1008404. (Demostration that MTBVAC confers non specific effects similarly to BCG).

"Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomized controlled, double-blind dose-escalation trial". Tameris M, Mearns H, Penn-Nicholson A, Gregg Y, Bilek N, Mabwe S, Geldenhuys H, Shenje J, Luabeya AKK, Murillo I, Doce J, Aguilo N, Marinova D, Puentes E, Rodríguez E, Gonzalo-Asensio J, Fritzell B, Thole J, Martin C, Scriba TJ, Hatherill M; MTBVAC Clinical Trial Team. Lancet Respir Med. 2019 Sep;7(9):757-770. D (Phase 1b of MTBVAC in newbors in an endemic country, South Africa) .

"New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages". Gonzalo-Asensio J, Pérez I, Aguiló N, Uranga S, Picó A, Lampreave C, Cebollada A, Otal I, Samper S, Martín C. PLoS Genet. 2018 Apr 12;14(4):e1007282. (IS6110 is important in the evolution of M. tuberculosis complex) .

"Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis". Aguilo N, Gonzalo-Asensio J, Alvarez-Arguedas S, Marinova D, Gomez AB, Uranga S, Spallek R, Singh M, Audran R, Spertini F, Martin C. Nat Commun. 2017 Jul 14;8:16085.(The mechanism of protection of MTBVAC is linked to the deletion region RD1 lost in BCG).

"Pulmonary but Not Subcutaneous Delivery of BCG Vaccine Confers Protection to Tuberculosis-Susceptible Mice by an Interleukin 17-Dependent Mechanism". Aguilo N, Alvarez-Arguedas S, Uranga S, Marinova D, Monzón M, Badiola J, Martin CJ Infect Dis. 2016 Mar 1;213(5):831-9. (Pulmonasry delivery of TB vaccines increase protection, strategy that in the future could help to TB control program to erradicate TB due to universal administration).

"Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: a randomised, double-blind, controlled phase I trial". Spertini F, Audran R, Chakour R, Karoui O, Steiner-Monard V, Thierry AC,Mayor CE, Rettby N, Jaton K, Vallotton L, Lazor-Blanchet C, Doce J, Puentes E, Marinova D, Aguilo N, Martin C. Lancet Respir Med. 2015 Dec;3(12):953-62. (A live attenuated TB vaccin entry first time in the history in humans).

"Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials". 1. Arbues A, Aguilo JI, Gonzalo-Asensio J, Marinova D, Uranga S, Puentes E, Fernandez C, Parra A, Cardona PJ, Vilaplana C, Ausina V, Williams A, Clark S, Malaga W, Guilhot C, Gicquel B, Martin C. Vaccine. 2013 Oct 1;(42):4867-73. (Construction, molecular characterization, safety anfd protection of first live ayttenuated vaccine following Geneva Consensus).

"An essential role for phoP in M. tuberculosis virulence". Pérez E, Samper S, Bordas Y, Guilhot C, Gicquel B, Martín C. Mol Microbiol. 2001 Jul;41(1):179-87. (Transcription factor regulating 2% M. tuberculosis genoma is essential for M. tuberculosis virulence).

"Strain identification of M. tuberculosis by DNA fingerprinting: recommendations for a standardized methodology. J Clin Microbiol". van Embden JD, Cave MD, Crawford JT, Dale JW, Eisenach KD, Gicquel B, Hermans P, Martin C, McAdam R, Shinnick TM, et al. 1993 Feb;31(2):406-9. (Standarization of first method for molecular typing of M tuberculosis, reference article cited more than 2.000 times to date).

"Transposition of an antibiotic resistance element in mycobacteria". Martin C, Timm J, Rauzier J, Gomez-Lus R, Davies J, Gicquel B. Nature. 1990 Jun 21;345(6277):739-43. (first isolation of a transposon coding resistance to antibiotics in micobacterial ,the begining of micobacterial genetics).