Lars Nitschke - Selected Publications#

Fernades, V., Ercoli, G.,Benard, A., Brandl, C., Weber, G., Denny, P., Nitschke, L.*, Andrew, P.* (2020). The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection. PLOS Pathogen, in press. * equal contribution

Özgör L, Meyer S, Korn M, Terörde K and Nitschke L. (2018) Sialic acid ligand binding of CD22 and Siglec-G determines distinct B cell functions but it dispensable for B cell tolerance induction. J Immunol. 201, 2107-2116

Schmitt, H., Sell, S., Koch, J., Seefried, M., Sonnewald, S., Daniel, C., Winkler, T.W. and Nitschke, L. (2016). Siglec-H protects from virus-triggered severe systemic autoimmunity. J.Exp.Med. 213, 1627-1644

Gruber, S., Hendrikx, T., Tsiantoulas, D., Ozsvar-Kozma, M., Goderle, L., Mallat, Z., Witztum, J.L., Shiri-Sverdlov, R., Nitschke, L., and Binder, C.J. (2016). Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells. Cell Rep 14, 2348-2361.

Müller, J., Lunz, B., Schwab, I., Acs, A., Nimmerjahn, F., Daniel, C., and Nitschke, L. (2015). Siglec-G deficiency leads to autoimmunity in aging C57BL/6 mice. J Immunol 195, 51-60.

Müller J, Nitschke L. (2014) The role of CD22 and Siglec-G in B-cell tolerance and autoimmune disease. Nat Rev Rheumatol. 10, 422-8.

Bökers S, Urbat A, Daniel C, Amann K, Smith KG, Espéli M, Nitschke L. (2014) Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice. J Immunol. 192, 2994-3002.

Müller, J., I. Obermeier, M. Wöhner, C. Brandl, S. Mrotzek, S. Angermüller, P.C. Maity, M. Reth, and Nitschke, L. (2013). CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling. Proc Natl Acad Sci U S A 110, 12402-12407.

Ackermann, J.A., Radtke, D., Maurberger, A., Winkler, T.H., and Nitschke, L. (2011). Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca(2+) signalling. EMBO J 30, 1621-1633.

Hoffmann, A., Kerr, S., Jellusova, J., Zhang, J., Weisel, F., Wellmann, U., Winkler, T.H., Kneitz, B., Crocker, P.R., and Nitschke, L. (2007). Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population. Nat Immunol 8, 695-704.