Sheena Radford - Selected Publications#

H index 76, over 300 publications, almost 19,500 citations; average citation per item, 65

1. Screening and classifying small molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry
Young, L.M., Saunders, J.C., Mahood, R.A., Revill, C.H., Foster R.J., Tu, L.-H., Raleigh, D.P., Radford, S.E. & Ashcroft, A.E. (2015) Nature Chemistry, 7, 1, 73-81
131 citations

2. Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM
Iadanza, M.G., Higgins, A.J., Schiffrin, R., Calabrese, A.N., Brockwell, D.J., Ashcroft, A.E., Radford, S.E. & Ranson, N.A. (2016) Nature Comms, 7, 12865
59 citations

3. Skp is a multivalent chaperone of outer membrane proteins
Schiffrin, R., Calabrese, A.N., Devine, P.W.A., Harris, S.A., Ashcroft, A.E., Brockwell, D.J. & Radford, S.E. (2016) Nat. Struct. Mol. Biol. 23, 786-793
35 citations

4. An in vivo platform for identifying inhibitors of protein aggregation
Saunders, J.C., Young, L.M., Mahood, R.A., Revill, C.H., Foster, R.J., Jackson, M.P., Smith, D.A.M., Ashcroft, A.E., Brockwell, D.J. & Radford, S.E. (2016) Nature Chem. Biol., 12, 94-101
31 citations, highlighted in Nature Reviews Drug Discovery: A platform for probing protein-aggregation inhibitors, Bray, N. (2016) Nat. Rev Drug Discovery, Feb 2016 issue, doi:10.1038/nrd.2016.8

5. Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers
Young, L.M., Tu, L.H., Raleigh, D.P., Ashcroft, A.E. & Radford, S.E. (2017) Chem. Sci, 8, 5030-5040
12 citations

6. The structure of a β2-microglobulin fibril suggests a molecular basis for its amyloid polymorphism
Iadanza. M.G., Silvers, R., Boardman, J., Smith, H.I., Karamanos, T.K., Debelouchina, G.T., Su, Y., Griffin, R.G., Ranson, N.A., & Radford, S.E. (2018) Nature Comms., 9, 4517 – 4527
21 citations

7. Rapid mapping of protein interactions using tag-transfer photocrosslinkers
Horne, J.E., Walko, M., Calabrese, A.N., Levenstein, M.A., Brockwell, D.J., Kapur, N., Wilson, A.J. & Radford, S.E. (2018) Angew. Chemie, 57, 16688-16692
11 citations

8. Structural mapping of oligomeric intermediates in an amyloid assembly pathway
Karamanos, T.K., Jackson, M.P., Calabrese, A.N., Goodchild, S.C., Cawood, E.E., Thompson, G.S., Kalverda, A.P., Hewitt, E.W., & Radford, S.E. (2019) eLife 8, e46574
3 citations

9. Dual role of ribosome-binding domain of NAC as a potent suppressor of protein aggregation and aging-related proteinopathies
Shen, K., Gamerdinger, M., Chan, R., Gense, K., Martin, E.M., Sachs, N., Knight, P.D., Schlömer, R., Calabrese, A.N., Stewart, K.L., Leiendecker, L., Baghel, A, Radford, S.E., Frydman, J., Deuerling, E. (2019) Mol Cell, 74, 1-13
2 citations

10. A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function
Doherty, C.P.A., Ulamec, S.M., Maya-Martinez, R., Good, S.C., Makepeace, J., Khan, G.N., van Oosten-Hawle, P., Radford, S.E. & Brockwell, D.J. (2020) Nat. Struct. Mol. Biol., 27, 249-259
published 17th March 2020