Ulf Rapp - Selected publications#

1. Rapp UR, Korn C, Ceteci F, Karreman C, Luetkenhaus K, Serafin V, Zanucco E, Castro I, Potapenko T. MYC is a metastasis gene for non-small-cell lung cancer. PLoS One, 2009 Jun 24;4(6):e6029.

2. Nekhoroshkova, E., Albert, S., Becker, M. und U.R. Rapp. A-RAF kinase functions in ARF6 regulated endocytic membrane traffic. PLoS one, 2009;4(2):e4647.Epub 2009 Feb 27.

3. Dogan, T., Harms, G.S., Hekman, M., Karreman, Ch., Oberoi, T.K., Alnemri, E.S., Rapp, U.R. and K. Rajalingam. X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility. Nat. Cell Biol. 10, 1447-55. 2008.

4. Fischer, A., Baljuls, A., Reinders, J., Nekhoroshkova, E., Sibilski, C., Metz, R., Albert, S., Hekman, M. and U.R. Rapp. Regulation of RAF activity by 14-33 proteins – RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins. J. Biol. Chem.284, 3183-94. 2008.

5. Samoylenko, A., Byts, N., Rajalingam, K., von Ahsen, N., Rapp, U.R., Ehrenreich, H. And A.L. Sirén. Thrombopoietin inhibits nerve growth factor- induced neuronal differentiation and ERK signalling. Cell Signal. 20, 154-162. 2008.

6. Fischer, A., Hekman, M., Kuhlmann, J., Rubio I., Wiese, S. and U.R. Rapp. B- and C-RAF display essential differences in their binding to Ras: the Isotype Specific N-terminus of B-RAF facilitates Ras Binding. J. Biol. Chem. 282, 26503-26516, 2007.

7. Hekman, M., Albert, S., Galmiche, A., Rennefahrt, U., Fueller, J., Fischer, A., Puehringer, D., Wiese, S. and UR. Rapp. Reversible Membrane Interaction of BAD requires two C-terminal Lipid Binding Domains in Conjunction with 14-3-3 Protein Binding. J. Biol. Chem. 281, 17321-17336, 2006.

8. Camarero, G., Tyrsin, O.Y., Xiang, Ch., Pfeiffer, V., Pleiser, S., Wiese, S., Goetz, R. and U.R. Rapp. Cortical migration defects in mice expressing A-RAF from the B-RAF locus. Mol. Cell Biol. 26, 7103-7115, 2006.

9. Rapp, U.R., Rennefahrt, U. and J. Troppmair. Bcl-2 proteins: master switches at the intersection of death signaling and the survival control by Raf kinases. Biochim. Biophys. Acta. 1644, 149-158. 2005.

10. Rajalingam, K., Wunder, C., Brinkmann, V., Churin, Y., Hekman, M., Sievers, C., Rapp, U.R. and T. Rudel.Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration. Nat. Cell Biol. 7, 837-843. 2005.

11. Götz, R., Wiese, S., Takayama, S., Camarero, G.C., Rossoll, W., Schweizer, U., Troppmair, J., Jablonka, S., Holtmann, B., Reed, J., Rapp, U.R. and M. Sendtner. Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat. Neurosci. 8, 1169-78. 2005.

12. Robubi, A., Mueller, T., Fueller, J., Rapp, U.R. and Dandekar T. (2005) B-Raf and C-Raf signaling investigated in a simplified model of the mitogenic cascade. Biol. Chem. 386, 1165-1171.

13. Hekman M, Fischer A, Wennogle LP, Wang YK, Campbell SL, Rapp UR (2005) Novel C-Raf phosphorylation sites: Serine 296 and 301 participate in Raf regulation. FEBS Lett. 579, 464-468.

14. Zabowski V, Keramas G, Kilian K, Rapp UR, Ludwig S (2004) Mitogen-activated 3p kinase (3pK) is active in the nucleus. Exp. Cell. Res. 299, 101-109.

15. Kurzbauer R, Teis D, de Araujo MEG, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen,T (2004) Crystal structure of the p14/MP1 scaffolding complex: How a twin couple attaches MAP kinase signaling to late endosomes. Proc. Natl. Acad. Sci. USA 101, 10984-10989.

16. Le Mellay V, Houben R, Troppmair J, Hagemann C, Mazurek S, Frey U, Beigel J, Weber Ch, Benz R, Eigenbrodt E, Rapp UR (2002) Regulation of glycolysis by Raf protein serine/threonine kinases. Advan. Enzyme Regul. 42, 317-332.

17. Le Mellay V, Troppmair J, Benz R, Rapp UR (2002) Negative regulation of mitochondrial VDAC channels by C-Raf kinase. BMC Cell Biology 3, 14.

18. Raabe T, Rapp UR (2002) KSR- a regulator and scaffold protein of the MAP kinase pathway. Science´s stke 2002 (www.stke.org/cgi/content/full/sigtrans;2002/136/pe28)

19. Josef T., Bryant A, Frankel P., Wooden R, Kerkhoff E, Rapp UR, Foster DA (2002) Phospholipase D Overcomes Cell Cycle Arrest induced by High-intensity Raf Signaling Oncogene 21, 3651-3658.

20. Kerkhoff E, Leberfinger CB, Schmidt G, Aktories K, Rapp UR (2002) Diverse effects of RacV12 on cell transformation by Raf: partial inhibition of morphological transformation versus deregulation of cell cycle control. Biochim. Biophys. Acta 1589, 151-159.

21. Leberfinger CB, Borawski JM, Rapp UR, Kerkhoff E (2002)The Spir proteins link MAP kinase signaling to actin organization, vesicle transport and cell polarity. In: Stem Cell in Tissue Regeneration edited by G. Steinhoff, M. Freund, V. Jansson and A. Rolfs, Papst Science Publishers, 39-48.