Jonathan Seckl - Selected Publications#

Key publications (of ~380); career citation >38,000, h=96 (Web of Science)

Edwards CRW, Benediktsson R, Lindsay R, Seckl JR (1993). Dysfunction of the placental glucocorticoid barrier: a link between fetal environment and adult hypertension? Lancet 341: 355-357.
(Key paper proposing the 'glucocorticoid hypothesis' of fetal programming - 450 citations)

Kotelevtsev Y, Holmes MC, Burchell A, Jamieson PM, Best R, Brown R, Edwards CRW, Seckl JR, Mullins JJ (1997). 11ß-HSD type 1 knockout mice show attenuated glucocorticoid inducible responses and resist hyperglycaemia on obesity or stress. Proc Natl Acad Sci USA 94: 14924-14929.
(Critical evidence that 11beta-hydroxysteroid dehydrogenase type 1 is a glucocorticoid-amplifying enzyme in vivo - 700 citations)

Nyirenda M, Lindsay RS, Kenyon CJ, Burchell A and Seckl JR (1998). Glucocorticoid exposure in late gestation permanently programmes rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. J Clin Invest 101: 2174-2181.
(dissection of fetal programming of insulin-glucose homeostasis by fetal glucocorticoid exposure - 420 citations)

Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS (2001). A Transgenic Model of Visceral Obesity and the Metabolic Syndrome. Science 294: 2166-2170.
(key evidence that elevated 11beta-HSD type 1 in adipose tissue causes metabolic disease - 1,300 citations)

Yau JLW, Noble J, Kenyon CJ, Hibberd C, Kotelevtsev Y, Mullins JJ, Seckl JR (2001). Lack of tissue glucocorticoid reactivation in 11ß-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments. Proc Natl Acad Sci USA 98: 4716-4721. (First evidence that lack of 11beta-HSD type 1 in brain protects from cognitive impairments with age - 140 citations)

Morton NM, Holmes MC, Fievet C, Staels B, Mullins JJ, Seckl JR (2001). Improved lipid and lipoprotein profile, hepatic insulin sensitivity and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice. J Biol Chem 276: 25293-25300.

Sandeep T, Yau JLW, MacLullich AMW, Noble J, Deary I, Walker BR, Seckl JR (2004). Effects of 11ß-HSD inhibition on cognitive function in healthy elderly men and patients with type 2 diabetes. Proc Natl Acad Sci USA 101: 6734-9.
(evidence that inhibition of 11beta-HSD in elderly humans improves cognitive function, the basis for our drug discovery programme with a lead agent now in phase II clinical trials - 160 citations)

Weaver ICG, Cervoni N, Champagne FA, D’Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ (2004). Epigenetic programming by maternal behavior. Nature Neurosci 7: 847-854.
(important collaborative paper showing the epigenetic mechanism of developmental programming of the glucocorticoid receptor in the hippocampus. Also the first evidence of postnatal demethylation by environmental agents - 3,100 citations)

Beltram J , Carter R , Gorjanc G, Munger S , Svenson K, Rodríguez-Cuenca S, Moreno-Navarrete JM, Gibbins M, McFadden C, Gastaldello A, Naredo G, Zeyda M, Wang Z, Howie A, Saari A, Sipila P, Stulnig TM, Gudnasson V, Kenyon C, Seckl JR, Walker BR, Webster SP, Dunbar D , Vidal-Puig A, Churchhill G, Fernández-Real JM, Emilsson V, Horvat S, Michailidou Z, Barrios-Llerena M, Ramage L, Aird R, Morton N (2016). Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed anti-diabetic target in mice selected for leanness. Nature Medicine 22: 771-779. (Discovery of an adipose 'lean gene')

Wyrwoll CS, Noble J, Thomson A, Tesic D, Miller MR, Rog-Zielinska EA, Moran CM, Seckl JR, Chapman KE, Holmes MC (2016). Pravastatin ameliorates placental vascular defects, fetal growth, and cardiac function in a model of glucocorticoid excess. Proc Natl Acad Sci U S A. 113: 6265-70. (A potential therapy for fetal programming)