Gilbert Vassart#
Selection of main publications#
Vassart, G., S. Refetoff, H. Brocas, C. Dinsart, and J.E. Dumont (1975). Translation of thyroglobulin 33S messenger RNA as a means of determining thyroglobulin quaternary structure. Proc.Natl.Acad.Sci.U.S.A. 72:3839-3843.
Mercken, L., M.J. Simons, S. Swillens, M. Massaer, and G. Vassart (1985). Primary structure of bovine thyroglobulin deduced from the sequence of its 8,431-base complementary DNA. Nature 316:647-651.
Ricketts, M.H., V. Pohl, G. de Martynoff, C.D. Boyd, A.J. Bester, P.P. Van Jaarsveld, and G. Vassart (1985). Defective splicing of thyroglobulin gene transcripts in the congenital goitre of the Afrikander cattle. EMBO J. 4:731-737.
Libert, F., J. Ruel, M. Ludgate, S. Swillens, N. Alexander, G. Vassart, and C. Dinsart (1987). Thyroperoxidase, an auto-antigen with a mosaic structure made of nuclear and mitochondrial gene modules. EMBO J. 6:4193-4196.
Ricketts, M.H., M.J. Simons, J. Parma, L. Mercken, Q. Dong, and G. Vassart (1987). A nonsense mutation causes hereditary goitre in the Afrikander cattle and unmasks alternative splicing of thyroglobulin transcripts. Proc.Natl.Acad.Sci.U.S.A. 84:3181-3184.
Vassart G, Georges M, Monsieur R, Brocas H, Lequarre AS, Christophe D (1987). A sequence in M13 phage detects hypervariable minisatellites in human and animal DNA. Science 235:683-4.
Libert, F., M. Parmentier, A. Lefort, C. Dinsart, J. Van Sande, C. Maenhaut, M.J. Simons, J.E. Dumont, and G. Vassart (1989). Selective amplification and cloning of four new members of the G protein-coupled receptor family. Science 244:569-572.
Parmentier, M., F. Libert, C. Maenhaut, A. Lefort, C. Gerard, J. Perret, J. Van Sande, J.E. Dumont, and G. Vassart (1989). Molecular cloning of the thyrotropin receptor. Science 246:1620-1622.
Ledent, C., M. Parmentier, and G. Vassart (1990). Tissue-specific expression and methylation of a thyroglobulin- chloramphenicol acetyltransferase fusion gene in transgenic mice. Proc.Natl.Acad.Sci.U.S.A. 87:6176-6180.
Libert, F., S.N. Schiffmann, A. Lefort, M. Parmentier, C. Gerard, J.E. Dumont, J.J. Vanderhaeghen, and G. Vassart (1991). The orphan receptor cDNA RDC7 encodes an A1 adenosine receptor. EMBO J. 10:1677-1682.
Ieiri, T., P. Cochaux, H. Targovnik, M. Suzuki, S.I. Shimoda, J. Perret, and G. Vassart (1991). A 3' splice site mutation in the thyroglobulin gene responsible for congenital goitre with hypothyroidism. J.Clin.Invest. 88:1901-1905. Ledent, C., J.E. Dumont, G. Vassart, and M. Parmentier (1992). Thyroid expression of an A2 adenosine receptor transgene induces thyroid hyperplasia and hyperthyroidism. EMBO J. 11:537-542.
Abramowicz, M.J., H.M. Targovnik, V. Varela, P. Cochaux, L. Krawiec, M.A. Pisarev, F.V.E. Propato, G. Juvenal, H.A. Chester, and G. Vassart (1992). Identification of a mutation in the coding sequence of the human thyroid peroxidase gene causing congenital goiter. J.Clin.Invest. 90:1200-1204.
Parmentier, M., F. Libert, S. Schurmans, S. Schiffmann, A. Lefort, D. Eggerickx, C. Ledent, C. Mollereau, C. Gerard, J. Perret, A. Grootegoed, and G. Vassart (1992). Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Nature 355:453-455.
Parma, J., L. Duprez, J. Van Sande, P. Cochaux, C. Gervy-Decoster, J. Mockel, J.E. Dumont, and G. Vassart (1993). Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature 365:649-651.
Duprez, L., J. Parma, J. Van Sande, A. Alleier, J. Leclère, C. Schvartz, M.-J. Delisle, M. Decoulx, J. Orgiazzi, J.E. Dumont, and G. Vassart (1994). Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism. Nat.Gen. 7:396-401.
Kopp, P., J. Van Sande, J. Parma, L. Duprez, H. Gerber, E. Joss, L. Jameson, J.E. Dumont, and G. Vassart (1995). Brief report: congenital hyperthyroidism caused by a mutation in the thyrotropin receptor gene. N.Engl.J.Med. 19:150-154.
Meunier, J.C., C. Mollereau, L. Toll, C. Suaudeau, C. Moisand, P. Alvinerie, J.L. Butour, J.C. Guillemot, P. Ferrara, B. Monsarrat, H. Mazarguil, G. Vassart, M. Parmentier, and J. Costentin (1995). Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 377:532-535.
Samson, M., O. Labbe, C. Mollereau, G. Vassart, and M. Parmentier (1996). Molecular cloning and functional expression of a new human CC-Chemokine receptor gene. Biochemistry 35:3362-3367.
Samson, M., F. Libert, B.J. Doranz, J. Rucker, C. Liesnard, C.M. Farber, S. Saragosti, C. Lapouméroulie, J. Cognaux, C. Forceille, G. Muyldermans, C. Verhofstede, G. Burtonboy, M. Georges, T. Imai, S. Rana, Y. Yi, R.J. Smyth, R.G. Collman, R.W. Doms, G. Vassart, and M. Parmentier (1996). Resistance to HIV-1 infecton in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382:722-725.
Rucker J, Samson M, Doranz BJ, Libert F, Berson JF, Yi Y, Collman RG, Broder CC, Vassart G, Doms RW and Parmentier M (1996). Regions in -Chemokine Receptors CCR5 and CCR2b that Determine HIV-1 Cofactor Specificity. Cell 87: 437-446.
Abramowicz, M.J., L. Duprez, J. Parma, G. Vassart, and C. Heinrichs (1997). Familial congenital hypothyroidism due to inactivating mutation of the thyrotropin receptor causing profound hypoplasia of the thyroid gland. J.Clin.Invest. 99:3018-3024.
Ledent, C., J.M. Vaugeois, S.N. Schiffmann, T. Pedrazzini, M. El yacoubi, J.J. Vanderhaeghen, J. Costentin, J.K. Heath, G. Vassart, and M. Parmentier (1997). Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388:674-678.
Rodien, P., C. Brémont, ML. Raffin, J. Parma, J. Van Sande, S. Costagliola, JP. luton, G. Vassart, and L. Duprez (1998). Familial gestational hyperthyroidism caused by a mutant thyrotropin receptor hypersensitive to human chorionic gonadotropin. N.Engl.J.Med. 339:1823-1826.
Ledent, C., O. Valverde, G. Cossu, F. Petitet, J.F. Aubert, F. Beslot, G.A. Bohme, A. Imperato, T. Pedrazzini, B.P. Roques, G. Vassart, W. Fratta, and M. Parmentier (1999). Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283:401-404.
Smits G, Olatunbosun O, Delbaere A, Pierson R, Vassart G, Costagliola S (2003). Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor. N Engl J Med 349:760-6.
Wittamer V, Franssen JD, Vulcano M, Mirjolet JF, Le Poul E, Migeotte I, Brezillon S, Tyldesley R, Blanpain C, Detheux M, Mantovani A, Sozzani S, Vassart , Parmentier M, Communi D (2003) Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J Exp Med 198:977-85.
Smits G, Campillo M, Govaerts C, Janssens V, Richter C, Vassart G, Pardo L, Costagliola S (2003). Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity. EMBO J 22:2692-703.
Migeotte,I., Riboldi,E., Franssen,J.D., Gregoire,F., Loison,C., Wittamer,V., Detheux,M., Robberecht,P., Costagliola,S., Vassart,G., Sozzani,S., Parmentier,M., & Communi,D (2005). Identification and characterization of an endogenous chemotactic ligand specific for FPRL2. J Exp Med., 201: 83-93.
Laurent P, Becker JA, Valverde O, Ledent C, de Kerchove d'Exaerde A, Schiffmann SN, Maldonado R, Vassart G, Parmentier M (2005). The prolactin-releasing peptide antagonizes the opioid system through its receptor GPR10. Nat Neurosciences 8:1735-41.
Ledent C, Demeestere I, Blum D, Petermans J, Hamalainen T, Smits G, Vassart G (2005). Premature ovarian aging in mice deficient for Gpr3. Proc Natl Acad Sci USA 102:8922-6.
Urizar E, Montanelli L, Loy T, Bonomi M, Swillens S, Gales C, Bouvier M, Smits G, Vassart G, Costagliola S (2005). Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity. EMBO J 24:1954-64. Decaux G, Soupart A, Vassart G Non-peptide arginine-vasopressin antagonists: the vaptans. Lancet. 2008 May 10;371(9624):1624-32.
