Cheng Zhang - Selected Publications#

1. Lu Y, Meng L, Ren R, Wang X, Sui W, Xue F, Xie L, Chen A, Zhao Y, Yang J, Zhang W, Yu X, Xi B, Xu F, Zhang M*, Zhang Y*, Zhang C*. Paraspeckle protein NONO attenuates vascular calcification by inhibiting bone morphogenetic protein 2 transcription. Kidney Int. 2024 Feb 27:S0085-2538(24)00162-5.

2. Ma C, Li Y, Tian M, Deng Q, Qin X, Lu H, Gao J, Chen M, Weinstein LS, Zhang M, Bu P, Yang J, Zhang Y, Zhang C, Zhang W*. Gsα Regulates Macrophage Foam Cell Formation During Atherosclerosis. Circ Res. 2024 Mar 29;134(7):e34-e51.

3. Zhang J, Cao Y, Ren R, Sui W, Zhang Y*, Zhang M*, Zhang C*. Medium-Dose Formoterol Attenuated Abdominal Aortic Aneurysm Induced by EPO via β2AR/cAMP/SIRT1 Pathway. Adv Sci. 2024 Apr;11(15):e2306232.

4. Guo D, Wu Z, Xue F, Chen S, Ran X, Zhang C*, Yang J*. Association between the triglyceride-glucose index and impaired cardiovascular fitness in non-diabetic young population. Cardiovasc Diabetol. 2024 Jan 20;23(1):39.

5. Xu P, Cao Y, Zhang S, Liu X*, Zhang M*, Zhang C*. The predictive value of serum Dickkopf-1, Dickkopf-3 level to coronary artery disease and acute coronary syndrome. Int J Cardiol. 2024 May 15;403:131887.

6. Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S*, Yu X*, Zhang Y*, Sun JP*. Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science. 2023 Apr 7;380(6640):eadd6220.

7. Wang JL, Dou XD, Cheng J, Gao MX, Xu GF, Ding W, Ding JH, Li Y, Wang SH, Ji ZW, Zhao XY, Huo TY, Zhang CF, Liu YM, Sha XY, Gao JR, Zhang WH, Hao Y, Zhang C, Sun JP*, Jiao N*, Yu X*. Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab. 2023 Oct;5(10):1726-1746.

8. Yang Z, Wang JY, Yang F, Zhu KK, Wang GP, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P, Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H, Yu X*, Gao N*, Sun JP*. Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nat Chem Biol. 2023 Nov 9. doi: 10.1038/s41589-023-01456-6. Online ahead of print.

9. Zhang J, Guo Y, Zhao X, Pang J, Pan C, Wang J, Wei S, Yu X, Zhang C, Chen Y*, Yin H*, Xu F*. The role of aldehyde dehydrogenase 2 in cardiovascular disease. Nat Rev Cardiol. 2023 Jul;20(7):495-509.

10. Yang L, Huang C, Zhao M, Lee PMY, Zhang C, Yu Y*, Xi B*, Li J. Maternal hypertensive disorders during pregnancy and the risk of offspring diabetes mellitus in childhood, adolescence, and early adulthood: a nationwide population-based cohort study. BMC Med. 2023 Feb 16;21(1):59.

11. Sun J, Li Y, Zhao M, Yu X, Zhang C, Magnussen CG, Xi B*. Association of the American Heart Association's new "Life's Essential 8" with all-cause and cardiovascular disease-specific mortality: prospective cohort study. BMC Med. 2023 Mar 29;21(1):116.

12. Cheng C, Zhang J, Li X, Xue F, Cao L, Meng L, Sui W, Zhang M, Zhao Y, Xi B, Yu X, Xu F, Yang J*, Zhang Y*, Zhang C*. NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice. Signal Transduct Target Ther. 2023 Aug 9;8(1):290.

13. Meng L, Lu Y, Wang X, Cheng C, Xue F, Xie L, Zhang Y, Sui W, Zhang M, Zhang Y*, Zhang C*. NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-β1/Smad pathways. Sci Adv. 2023 Aug 2;9(31):eadd4222.

14. Lu H, Yuan P, Ma X, Jiang X, Liu S, Ma C, Philipsen S, Zhang Q, Yang J, Xu F, Zhang C, Zhang Y, Zhang W*. Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice. Nat Commun. 2023 Feb 9;14(1):731.

15. Lu H, Jiang X, He L, Ji X, Li X, Liu S, Sun Y, Qin X, Xiong X, Philipsen S, Xi B, Zhang M, Yang J, Zhang C, Zhang Y, Zhang W*. Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice. Nat Commun. 2023 Sep 21;14(1):5891.

16. Guo C, Ji W, Yang W, Deng Q, Zheng T, Wang Z, Sui W, Zhai C, Yu F, Xi B, Yu X, Xu F, Zhang Q, Zhang W, Kong J*, Zhang M*, Zhang C*. NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post-Myocardial Infarction via Human Antigen R. Adv Sci. 2023 Oct;10(30):e2303283.

17. Yang K, Cui S, Wang J, Xu T, Du H, Yue H, Ye H, Guo J, Zhang J, Li P, Guo Y, Pan C, Pang J, Wang J, Yu X, Zhang C, Liu Z, Chen Y*, Xu F*. Early Progression of Abdominal Aortic Aneurysm is Decelerated by Improved Endothelial Barrier Function via ALDH2-LIN28B-ELK3 Signaling. Adv Sci. 2023 Nov;10(32):e2302231.

18. Zhang J, Cao L, Gao A, Ren R, Yu L, Li Q, Liu Y, Qi W, Hou Y, Sui W, Su G, Zhang Y, Zhang C*, Zhang M*. E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2. Cell Death Differ. 2023 Apr;30(4):966-978.

19. Qiao L, Hu J, Qiu X, Wang C, Peng J, Zhang C, Zhang M*, Lu H*, Chen W*. LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles. Autophagy. 2023 Nov;19(11):2837-2852.

20. Chen W, Ni M, Huang H, Cong H, Fu X, Gao W, Yang Y, Yu M, Song X, Liu M, Yuan Z, Zhang B, Wang Z, Wang Y, Chen Y*, Zhang C*, Zhang Y*. Chinese expert consensus on the diagnosis and treatment of coronary microvascular diseases (2023 Edition). MedComm (2020). 2023 Dec 19;4(6):e438.

21. Li Q, Yu L, Gao A, Ren R, Zhang J, Cao L, Wang X, Liu Y, Qi W, Cai L, Li W, Wang W, Guo X, Su G, Yu X, Zhang J, Xi B, Zhang Y, Zhang M, Zhang C*. METTL3 (Methyltransferase Like 3)-Dependent N6-Methyladenosine Modification on Braf mRNA Promotes Macrophage Inflammatory Response and Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol. 2023 May;43(5):755-773.

22. Deng Q, Li H*, Yue X, Guo C, Sun Y, Ma C, Gao J, Wu Y, Du B, Yang J, Zhang C*, Zhang W*. Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6. Cell Death Dis. 2023 Aug 22;14(8):542.

23. Wu Z, Cheng C, Sun X, Wang J, Guo D, Chen S, Zhang Y, Liu X, Liu L, Zhang C*, Yang J*. The synergistic effect of the triglyceride-glucose index and serum uric acid on the prediction of major adverse cardiovascular events after coronary artery bypass grafting: a multicenter retrospective cohort study. Cardiovasc Diabetol. 2023 May 2;22(1):103.

24. Tian Z, Zhang Y, Zheng Z, Zhang M, Zhang T, Jin J, Zhang X, Yao G, Kong D, Zhang C*, Wang Z*, Zhang Q*. Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation. Cell Host Microbe. 2022 Oct 12;30(10):1450-1463.e8.

25. Xue F, Cheng J, Liu Y, Cheng C, Zhang M, Sui W, Chen W, Hao P*, Zhang Y*, Zhang C*. Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice. Signal Transduct Target Ther. 2022 Aug 1;7(1):259.

26. Yu L, Zhang J, Gao A, Zhang M, Wang Z, Yu F, Guo X, Su G, Zhang Y, Zhang M*, Zhang C*. An intersegmental single-cell profile reveals aortic heterogeneity and identifies a novel Malat1+ vascular smooth muscle subtype involved in abdominal aortic aneurysm formation. Signal Transduct Target Ther. 2022 Apr 27;7(1):125.

27. Qiao L, Zhang M*, Zhang C*. Vascular macrophages sense octanal and drive athero-inflammation. Cell Mol Immunol. 2022 Jul 4.

28. Jin J, Gao L, Zou X, Zhang Y, Zheng Z, Zhang X, Li J, Tian Z, Wang X, Gu J, Zhang C*, Wu T*, Wang Z*, Zhang Q*. Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts. Circ Res. 2022 Sep 2;131(6):492-506.

29. Wang Z, Wang H, Guo C, Yu F, Zhang Y, Qiao L, Zhang H, Zhang C*. Role of hsa_circ_0000280 in regulating vascular smooth muscle cell function and attenuating neointimal hyperplasia via ELAVL1. Cell Mol Life Sci. 2022 Dec 7;80(1):3. doi: 10.1007/s00018-022-04602-w. PMID: 36477660; PMCID: PMC9729135.

30. Chen Y, Wu X, Zhang J, Pan G, Wang X, Guo X, Wang J, Cui X, Gao H, Cheng M, Yang J, Zhang C*, Jiang F*. Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance. EMBO Rep. 2022 Feb 3;23(3):e53373.

31. Di M, Zhang Y, Zeng R, Liu X, Chen W, Zhang M, Zhang C, Li M*, Zhang M*. The pro-angiogenesis effect of miR33a-5p/Ets-1/DKK1 signaling in ox-LDL induced HUVECs. Int J Biol Sci. 2021 Oct 3;17(15):4122-4139.

32. Sheng Y, Li M, Xu M, Zhang Y, Xu J, Huang Y, Li X, Yao G, Sui W, Zhang M, Zhang Y, Zhang C, Zhang Y*, Zhang M*. Left ventricular and atrial remodelling in hypertensive patients using thresholds from international guidelines and EMINCA data. Eur Heart J Cardiovasc Imaging. 2022 Jan 24;23(2):166-174.

33. Qiao L, Ma J, Zhang Z, Sui W, Zhai C, Xu D, Wang Z, Lu H, Zhang M, Zhang C, Chen W*, Zhang Y*. Deficient Chaperone-Mediated Autophagy Promotes Inflammation and Atherosclerosis. Circ Res. 2021 Dec 3;129(12):1141-1157.

34. Ma J, Liu X, Qiao L, Meng L, Xu X, Xue F, Cheng C, Han Z, Lu Y, Zhang W, Bu P, Zhang M, An G, Lu H, Ni M*, Zhang C*, Zhang Y*. Association Between Stent Implantation and Progression of Nontarget Lesions in a Rabbit Model of Atherosclerosis. Circ Cardiovasc Interv. 2021 Nov;14(11):e010764.

35. Zhang J, Cao L, Wang X, Li Q, Zhang M, Cheng C, Yu L, Xue F, Sui W, Sun S, Li N, Bu P, Liu B, Gao F, Zhen J, Su G, Zhang C, Gao C*, Zhang M*, Zhang Y*. The E3 ubiquitin ligase TRIM31 plays a critical role in hypertensive nephropathy by promoting proteasomal degradation of MAP3K7 in the TGF-β1 signaling pathway. Cell Death Differ. 2022 Mar;29(3):556-567.

36. Zhang M, Sui W, Cheng C, Xue F, Tian Z, Cheng J, Zhang J, Zhang T, Zhang J, Wang W, Xiong W, Hao P, Ma J, Xu X, Wang S, Sun S, Zhang M*, Zhang Y*, Zhang C*. Erythropoietin promotes abdominal aortic aneurysms in mice through angiogenesis and inflammatory infiltration. Sci Transl Med. 2021 Jul 21;13(603):eaaz4959.

37. Zhang M, Sui W, Xing Y, Cheng J, Cheng C, Xue F, Zhang J, Wang X, Zhang C*, Hao P*, Zhang Y*. Angiotensin IV attenuates diabetic cardiomyopathy via suppressing FoxO1-induced excessive autophagy, apoptosis and fibrosis. Theranostics. 2021 Jul 25;11(18):8624-8639.

38. Yu F, Zhang Y, Wang Z, Gong W, Zhang C*. Hsa_circ_0030042 regulates abnormal autophagy and protects atherosclerotic plaque stability by targeting eIF4A3. Theranostics. 2021 Mar 12;11(11):5404-5417.

39. Zhang T, Li H, Ouyang C, Cao G, Gao J, Wu J, Yang J, Yu N, Min Q, Zhang C*, Zhang W*. Liver kinase B1 inhibits smooth muscle calcification via high mobility group box 1. Redox Biol. 2021 Jan;38:101828.

40. Zheng TF, Liu XL, Li X, Wang QQ, Zhao YC, Li X, Li MM, Zhang Y, Zhang M, Zhang WC, Zhang C, Zhang Y*, Zhang M*. Dickkopf-1 promotes Vascular Smooth Muscle Cell proliferation and migration through upregulating UHRF1 during Cyclic Stretch application. Int J Biol Sci. 2021 Mar 21;17(5):1234-1249.

41. Liu S, Jiang X, Cui X, Wang J, Liu S, Li H, Yang J, Zhang C, Zhang W*. Smooth muscle-specific HuR knockout induces defective autophagy and atherosclerosis. Cell Death Dis. 2021 Apr 9;12(4):385.

42. Tian M, Wang J, Liu S, Li X, Li J, Yang J, Zhang C, Zhang W*. Hepatic HuR protects against the pathogenesis of non-alcoholic fatty liver disease by targeting PTEN. Cell Death Dis. 2021 Mar 4;12(3):236.

43. Xu X, Xu X, Mao Y, Lu L, MaJ, Zheng T, Zhang J, Zhang M, Meng L, Ma L, Cheng J, Chen W, Jiang H, Zhang Y*, Zhang C*. Knockout of the NONO Gene Inhibits Neointima Formation in a Mouse Model of Vascular Injury. Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1428-1445.

44. Xu M, Jin S, Li F, Jia G, Zhang C, Zhang M, Zhang Y*. The Diagnostic Value of Radial and Carotid Intima Thickness Measured by High-Resolution Ultrasound for Ischemic Stroke. J Am Soc Echocardiogr. 2021 Jan;34(1):72-82.

45. Xue F, Yang J, Cheng J, Sui W, Cheng C, Li H, Zhang M, Zhang J, Xu X, Ma J, Lu L, Xu J, Zhang M, Zhang Y*, Zhang C*. Angiotensin-(1-7) mitigated angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-knockout mice. Br J Pharmacol. 2020 Apr;177(8):1719-1734.

46. Liu S, Jiang X, Lu H, Xing M, Qiao Y, Zhang C*, Zhang W*. HuR (Human Antigen R) Regulates the Contraction of Vascular Smooth Muscle and Maintains Blood Pressure. Arterioscler Thromb Vasc Biol. 2020 Apr;40(4):943-957.

47. Xu M, Hu X, Wang L, Zhang W, Wu L, Li J, Chen Y, Zhang P, Su H, Han Y, Zhang C, Zhang M, Zhang Y*. Plasma biomarkers and plaque strain predict long-term cardiovascular events in patients with acute coronary syndrome. Sci China Life Sci. 2020 Feb;63(2):269-278.

48. Meng X, Liu Y, Wei C, Zhang K, Zhang Y, Zhong M, Zhang C*, Zhang Y*. Angiotensin converting enzyme inhibitors and angiotensin receptor blockers improved the outcome of patients with severe COVID-19 and hypertension. Sci China Life Sci. 2021 May;64(5):836-839.

49. Yu F, Tie Y, Zhang Y, Wang Z, Yu L, Zhong L, Zhang C*. Circular RNA expression profiles and bioinformatic analysis in coronary heart disease. Epigenomics. 2020 Mar;12(5):439-454.

50. Li J, Gong L, Liu S, Zhang Y, Zhang C, Tian M, Lu H, Bu P, Yang J, Ouyang C, Jiang X, Wu J, Zhang Y, Min Q, Zhang C*, Zhang W*. Adipose HuR protects against diet-induced obesity and insulin resistance. Nat Commun. 2019 May 30;10(1):2375.

51. Sui W, Li H, Yang Y, Jing X, Xue F, Cheng J, Dong M, Zhang M, Pan H, Chen Y, Zhang Y, Zhou Q, Shi W, Wang X, Zhang H, Zhang C, Zhang Y*, Cao Y*. Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10937-10942.

52. Yao G, Chen X, Zhang Q, Zeng X, Li X, Zhang S, Jiang P, Feng X, Sun F, Xu J, Zhang M, Zhang C, Yin L, Zhang M, Zhang Y*. A Novel Mathematical Model for Correcting the Physiologic Variance of Two-Dimensional Echocardiographic Measurements in Healthy Chinese Adults. J Am Soc Echocardiogr. 2019 Jul;32(7):876-883.e11.

53. Xu M, Zhang M, Xu J, Zhu M, Zhang C, Zhang P*, Zhang Y.* The independent and add-on values of radial intima thickness measured by ultrasound biomicroscopy for diagnosis of coronary artery disease. Eur Heart J Cardiovasc Imaging. 2019 Aug 1;20(8):889-896.

54. Hu Q, Hao P, Liu Q, Dong M, Gong Y, Zhang C, Zhang Y*. Mendelian randomization studies on atherosclerotic cardiovascular disease: evidence and limitations. Sci China Life Sci. 2019 Jun;62(6):758-770.

55. Karamariti E, Zhai C, Yu B, Qiao L, Wang Z, Potter C, Wong M, Simpson R, Zhang Z, Wang X, Del Barco, Niehrs C, Kong D, Zhao Q, Zhang Y, Hu Y, Zhang C*, Xu Q*. DKK3 (Dickkopf 3) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation Into Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):425-437.

56. Qin X, Liu S, Lu Q, Zhang M, Jiang X, Hu S, Li J, Zhang C, Gao J, Zhu MS, Zhang Y*, Zhang W*. Heterotrimeric G Stimulatory Protein α Subunit Is Required for Intestinal Smooth Muscle Contraction in Mice. Gastroenterology. 2017 Apr;152(5):1114-1125.e5.

57. Yang X, Sui W, Zhang M, Dong M, Lim S, Seki T, Guo Z, Fischer C, Lu H, Zhang C, Yang J, Zhang M, Wang Y, Cao C, Gao Y, Zhao X, Sun M, Sun Y, Zhuang R, Samani NJ, Zhang Y*, Cao Y*. Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions. JCI Insight. 2017 Feb 23;2(4):e89044.

58. Zhang W, Ding Y, Zhang C, Lu Q, Liu Z, Coughlan K, Okon I, Zou MH*. Deletion of endothelial cell-specific liver kinase B1 increases angiogenesis and tumor growth via vascular endothelial growth factor. Oncogene. 2017 Jul 27;36(30):4277-4287.

59. Meng X, Yang J, Dong M, Zhang K, Tu E, Gao Q, Chen W, Zhang C*, Zhang Y*. Regulatory T cells in cardiovascular diseases. Nat Rev Cardiol. 2016 Mar;13(3):167-79.

60. Yao GH, Zhang M, Yin LX, Zhang C, Xu MJ, Deng Y, Liu Y, Deng YB, Ren WD, Li ZA, Tang H, Zhang QB, Mu YM, Fang LG, Zhang Y*. Echocardiographic Measurements in Normal Chinese Adults (EMINCA) Study Investigators. Doppler Echocardiographic Measurements in Normal Chinese Adults (EMINCA): a prospective, nationwide, and multicentre study. Eur Heart J Cardiovasc Imaging. 2016 May;17(5):512-22.

61. Hao PP, Jiang F, Chen YG, Yang J, Zhang K, Zhang MX, Zhang C, Zhao YX, Zhang Y*. Traditional Chinese medication for cardiovascular disease. Nat Rev Cardiol. 2015 Jun;12(6):318.

62. Hao PP, Jiang F, Chen YG, Yang J, Zhang K, Zhang MX, Zhang C, Zhao YX, Zhang Y*. Evidence for traditional Chinese medication to treat cardiovascular disease. Nat Rev Cardiol. 2015 Jun;12(6):374.

63. Zhang K, Meng X, Li D, Yang J, Kong J, Hao P, Guo T, Zhang M, Zhang Y*, Zhang C*. Angiotensin (1-7) attenuates the progression of streptozotocin-induced diabetic renal injury better than angiotensin receptor blockade. Kidney Int. 2015 Feb;87(2):359-69.

64. Kong J, Zhang K, Meng X, Zhang Y*, Zhang C*. Dose-Dependent Bidirectional Effect of Angiotensin IV on Abdominal Aortic Aneurysm via Variable Angiotensin Receptor Stimulation. Hypertension. 2015 Sep;66(3):617-26.

65. Yao GH, Deng Y, Liu Y, Xu MJ, Zhang C, Deng YB, Ren WD, Li ZA, Tang H, Zhang QB, Mu YM, Fang LG, Zhang M, Yin LX, Zhang Y*. Echocardiographic Measurements in Normal Chinese Adults (EMINCA) Study Investigators. Echocardiographic measurements in normal chinese adults focusing on cardiac chambers and great arteries: a prospective, nationwide, and multicenter study. J Am Soc Echocardiogr. 2015 May;28(5):570-9.

66. Yao GH, Deng Y, Liu Y, Xu MJ, Zhang C, Deng YB, Ren WD, Li ZA, Tang H, Zhang QB, Mu YM, Fang LG, Zhang M*, Yin LX*, Zhang Y*. Echocardiographic Measurements in Normal Chinese Adults (EMINCA) Study Investigators. Echocardiographic measurements in normal chinese adults focusing on cardiac chambers and great arteries: a prospective, nationwide, and multicenter study. J Am Soc Echocardiogr. 2015 May;28(5):570-9.

67. Liu X, Ni M, Ma L, Yang J, Wang L, Liu F, Dong M, Yang X, Zhang M, Lu H, Wang J, Zhang C, Jiang F, Zhang Y*. Targeting blood thrombogenicity precipitates atherothrombotic events in a mouse model of plaque destabilization. Sci Rep. 2015 May 11;5:10225.

68. Hao P, Yang J, Liu Y, Zhang M, Zhang K, Gao F, Chen Y, Zhang C*, Zhang Y*. Combination of angiotensin-(1-7) with perindopril is better than single therapy in ameliorating diabetic cardiomyopathy. Sci Rep. 2015 Mar 5;5:8794.

69. Zhao X, Kong J, Zhao Y, Wang X, Bu P, Zhang C*, Zhang Y*. Gene silencing of TACE enhances plaque stability and improves vascular remodeling in a rabbit model of atherosclerosis. Sci Rep. 2015 Dec 14;5:17939.

70. Yang J, Sun Y, Dong M, Yang X, Meng X, Niu R, Guan J, Zhang Y*, Zhang C*. Comparison of angiotensin-(1-7), losartan and their combination on atherosclerotic plaque formation in apolipoprotein E knockout mice. Atherosclerosis. 2015 Jun;240(2):544-9.

71. Liu BS, Xu F, Wang JL, Zhang C, Zhang Y, Hao PP*, Chen YG*. The cardioprotection of ischemic postconditioning in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Int J Cardiol. 2015 Jan 15;178:181-3.

72. Jiang F, Yang J, Zhang Y, Dong M, Wang S, Zhang Q, Liu FF, Zhang K, Zhang C*. Angiotensin-converting enzyme 2 and angiotensin 1-7: novel therapeutic targets. Nat Rev Cardiol. 2014 Jul;11(7):413-26.

73. Hao PP, Shang R, Liu YP, Hou GH, Zhang MX, Zhang C, Chen YG*, Zhang Y*. Cardiogenic shock from acute ST-segment elevation myocardial infarction induced by severe multivessel coronary vasospasm. Eur Heart J. 2014 Jan;35(3):146.

74. Meng X, Yang J, Zhang K, An G, Kong J, Jiang F, Zhang Y*, Zhang C*. Regulatory T cells prevent angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E knockout mice. Hypertension. 2014 Oct;64(4):875-82.

75. Li B, Luo B, Qin W, Liu H, Xia YF, Liu T, Li J, Zhang MX, Zhang Y, Zhang C, An F*. Bidirectional effect of serum amyloid A on plaque stability. Int J Cardiol. 2014 Jun 1;174(1):179-83.

76. Dong M, Yang X, Lim S, Cao Z, Honek J, Lu H, Zhang C, Seki T, Hosaka K, Wahlberg E, Yang J, Zhang L, Länne T, Sun B, Li X, Liu Y, Zhang Y*, Cao Y*. Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis. Cell Metab. 2013 Jul 2;18(1):118-29.

77. Zhang C, Zeng L, Emanueli C, Xu Q*. Blood flow and stem cells in vascular disease. Cardiovasc Res. 2013 Jul 15;99(2):251-9.

78. Yang JM, Dong M, Meng X, Zhao YX, Yang XY, Liu XL, Hao PP, Li JJ, Wang XP, Zhang K, Gao F, Zhao XQ, Zhang MX, Zhang Y*, Zhang C*. Angiotensin-(1-7) dose-dependently inhibits atherosclerotic lesion formation and enhances plaque stability by targeting vascular cells. Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1978-85.

79. Li B, Dong Z, Liu H, Xia YF, Liu XM, Luo BB, Wang WK, Li B, Gao F, Zhang C, Zhang MX, Zhang Y, An FS*. Serum amyloid A stimulates lipoprotein-associated phospholipase A2 expression in vitro and in vivo. Atherosclerosis. 2013 Jun;228(2):370-9.

80. Meng X, Li W, Yang J, Zhang K, Qin W, An G, Gao F, Wang Y, Zhang C*, Zhang Y*. Regulatory T cells prevent plaque disruption in apolipoprotein E-knockout mice. Int J Cardiol. 2013 Oct 3;168(3):2684-92.

81. Hao PP, Liu YP, Hou GH, Zhang MX, Chen YG, Zhang Y*, Zhang C*. Usefulness of angiotensin-(1-7) to predict myocardial salvage after percutaneous coronary intervention in patients with acute myocardial infarction. Int J Cardiol. 2013 Sep 20;168(1):614-6.

82. Wang SX#, Zhang C#, Zhang M, Liang B, Lee J, Zhu HP , Viollet B, Xia LJ, Zhang Y, Zou MH. Activation of AMP-activated protein kinase alpha2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo. Nat Med. 2012,18(6), 902-910

83. Dong B, Yu QT, Dai HY, Gao YY, Zhou ZL, Zhang L, Jiang H, Gao F, Li SY, Zhang YH, Bian HJ, Liu CX, Wang N, Xu H, Pan CM, Song HD, Zhang C*, Zhang Y*. Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy. J Am Coll Cardiol. 2012 Feb 21;59(8):739-47.

84. Li JJ, Meng X, Si HP, Zhang C, Lv HX, Zhao YX, Yang JM, Dong M, Zhang K, Liu SX, Zhao XQ, Gao F, Liu XL, Cui TX*, Zhang Y*. Hepcidin destabilizes atherosclerotic plaque via overactivating macrophages after erythrophagocytosis. Arterioscler Thromb Vasc Biol. 2012 May;32(5):1158-66.

85. Li J#, Zhang C#, Xing Y, Janicki JS, Yamamoto M, Wang XL, Tang DQ, Cui T. Up-regulation of p27kip1 contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy. Cardiovasc Res. 2011, 90(2): 315-324

86. Zhao XQ, Zhang MW, Wang F, Zhao YX, Li JJ, Wang XP, Bu PL, Yang JM, Liu XL, Zhang MX, Gao F, Zhang C*, Zhang Y*. CRP enhances soluble LOX-1 release from macrophages by activating TNF-alpha converting enzyme. J Lipid Res. 2011, 52(5): 923-933

87. Zhang C#, Zhao YX, Zhang YH, Zhu L, Deng BP, Zhou ZL, Li SY, Lu XT, Song LL, Lei XM, Tang WB, Wang N, Pan CM, Song HD, Liu CX, Dong B, Zhang Y, Cao YH. Angiotensin-converting enzyme 2 attenuates atherosclerotic lesions by targeting vascular smooth muscle cells and endothelial cells. P Natl Acad Sci USA. 2010, 107(36):15886-15891

88. Liu P#, Zhang C#, Zhao YX, Feng JB, Liu CX, Chen WQ, Yao GH, Zhang M, Wang XL, Zhang Y. Gax gene transfer inhibits vascular remodeling induced by adventitial inflammation in rabbits. Atherosclerosis. 2010, 212(2):398-405

89. Zhang L, Liu Y, Zhang PF, Zhao YX, Ji XP, Lu XT, Chen WQ, Liu CX, Zhang C, Zhang Y. Peak radial and circumferential strain measured by velocity vector imaging is a novel index for detecting vulnerable plaques in a rabbit model of atherosclerosis. Atherosclerosis. 2010, 211(1):146-152

90. Guo T#, Chen WQ#, Zhang C#, Zhao YX, Zhang Y. Chymase activity is closely related with plaque vulnerability in a hamster model of atherosclerosis. Atherosclerosis. 2009, 207(1): 59-67

91. Li XN, Song J, Zhang L, LeMaire S, Hou XY, Zhang C, Coselli J, Chen L, Wang XL, Zhang Y, Shen YH. Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin. Diabetes. 2009, 58(10): 2246-2257

92. Liu P#, Zhang C#, Feng JB#, Zhao YX, Wang XP, Yang JM, Zhang MX, Wang XL, Zhang Y. Cross-Talk among smad, MAPK, and integrin signaling pathways enhances adventitial fibroblast functions activated by transforming growth factor {beta} 1 and inhibited by gax. Arterioscler Thromb Vasc Biol 2008, 28(4):725-731

93. Dong B#, Zhang C#, Feng J#, Zhao Y, Li S, Yang Y, Dong Q, Deng B, Zhu L, Yu Q, Liu C, Liu B, Pan C, Song H, Zhang M, Zhang Y. Overexpression of ACE2 enhances plaque stability in a rabbit model of atherosclerosis. Arterioscler Thromb Vasc Biol 2008, 28(7): 1270-1276

94. Zhang C#, Zhang MX, Shen YH, Burks JK, Li XN , LeMaire SA, Yoshimura K, Aoki H, Matsuzaki M, An FS, Engler D, Matsunami R, Coselli JS, Zhang Y, Wang XL. Role of NonO-histone interaction in TNFα-suppressed Prolyl-4-hydroxylase α1. BBA-Mol Cell Res. 2008, 1783(8): 1517-1528

95. Zhang C#, Zhang MX, Shen YH, Burks JK, Zhang Y, Wang J, LeMaire SA, Yoshimura K, Aoki H, Coselli JS, Wang XL. TNF-alpha suppresses prolyl-4-hydroxylase alpha1 expression via the ASK1-JNK-NonO pathway. Arterioscler Thromb Vasc Biol 2007, 27(8): 1760-1767

96. Zhong JQ, Zhang W, Li Y, Zhong M, Li DL, Zhang C, Zhang Y. Changes in connexin metalloproteinase and tissue inhibitor of metalloproteinase during tachycardia-induced cardiomyopathy in dogs. Eur J Heart Fail. 2007, 9(1): 23-29