Ingrid Fleming - Selected Publications#

Identification: Researcher ID: L-1225-2014, ORCID 0000-0003-1881-3635
Citationmetrics: Total citations 28679, average citations per paper : 76.66, h-index: 88 (Google Scholar).

1. Fisslthaler B, Popp R, Kiss L, Potente M, Harder DR, Fleming I*, Busse R. Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature. 1999;401:493-497. *Corresponding author (943 citations)

2. Fleming I, Michaelis UR, Bredenkotter D, Fisslthaler B, Dehghani F, Brandes RP, Busse R. Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. Circ Res. 2001;88:44-51. (433 citations)

3. Fleming I, Fisslthaler B, Dimmeler S, Kemp BE, Busse R. Phosphorylation of Thr495 regulates Ca2+/calmodulin-dependent endothelial nitric oxide synthase activity. Circ Res. 2001;88:e68-e75. (707 citations)

4. Loot AE, Schreiber JG, Fisslthaler B, Fleming I. Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase. J Exp Med 2009;206:2889-96. (106 citations)

5. Frömel T, Jungblut B, Hu J, Trouvain C, Barbosa-Sicard E, Popp R, Liebner S, Dimmeler S, Hammock BD, Fleming I. Soluble epoxide hydrolase regulates hematopoietic progenitor cell function via generation of fatty acid diols. Proc Natl Acad Sci USA 2012;109:9995-10000. (46 citations)

6. Shi L, Fisslthaler B, Zippel N, Frömel T, Hu J, Elgheznawy A, Heide H, Popp R, Fleming I. MicroRNA-223 antagonizes angiogenesis by targeting β1 integrin and preventing growth factor signaling in endothelial cells. Circ Res 2013;113:1320-1330. One of the 10 most read articles published in Circulation Research in 2013 (see Bolli R. Circ Res. 2014;114:765-9). (64 citations)

7. Hu J, Popp R, Frömel T, Ehling M, Awwad K, Adams RH, Hammes HP, Fleming I. Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid. J Exp Med 2014;211:281-295. (33 citations)

8. Elgheznawy A, Shi L, Hu J, Wittig I, Laban H, Pircher J, Mann A, Provost P, Randriamboavonjy V, Fleming I. Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes. Circ Res. 2015;117:157-65. (26 citations)

9. Abdel Malik R, Zippel N, Frömel T, Heidler J, Zukunft S, Walzog B, Ansari N, Pampaloni F, Wingert S, Rieger MA, Wittig I, Fisslthaler B, Fleming I. AMP-activated protein kinase α2 in neutrophils regulates hypoxia-inducible factor-1α and a network of proteins affecting metabolism and vascular repair after ischemia. Circ Res. 2017; 120:99-109. (Editorial: Satoh K. AMPKα2 regulates hypoxia-inducible factor-1α stability and neutrophil survival to promote vascular repair after ischemia. Circ Res. 2017;120:8-10) (7 citations)

10. Hu J, Dziumbla S, Lin J, Bibli S-I, Zukunft S, de Mos J, Awwad K, Frömel T, Jungmann A, Devraj K, Cheng Z, Wang L, Fauser S, Eberhart CG, Sodhi A, Hammock BD, Liebner S, Müller OJ, Glaubitz C, Hammes H-P, Popp R, Fleming I. Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy. Nature 2017;552:248-52. (Editorial: Yanagida & Hla. A dark side to omega-3 fatty acids. Nature News & Views 2017;552)