Hugues de Thé - Selected Publications#

H factor 82

de The, H., C. Chomienne, M. Lanotte, L. Degos and A. Dejean (1990). "The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus." Nature 347(6293): 558-561.

Koken, M. H. M., F. Puvion-Dutilleul, M. C. Guillemin, A. Viron, G. Linares-Cruz, N. Stuurman, L. de Jong, C. Szostecki, F. Calvo, C. Chomienne, L. Degos, E. Puvion and H. de Thé (1994). "The t(15;17) translocation alters a nuclear body in a RA-reversible fashion." EMBO J. 13: 1073.

Zhu, J., M. H. Koken, F. Quignon, M. K. Chelbi-Alix, L. Degos, Z. Y. Wang, Z. Chen and H. de The (1997). "Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia." Proceedings of the National Academy of Sciences of the United States of America 94(8): 3978-3983.

Lallemand-Breitenbach, V., M.-C. Guillemin, A. Janin, M.-T. Daniel, L. Degos, S. C. Kogan, J. M. Bishop and H. de The (1999). "Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia." J. Exp. Med. 189: 1043-1052.

Zhu, J., M. Gianni, E. Kopf, N. Honore, M. Chelbi-Alix, M. Koken, F. Quignon, C. Rochette-Egly and H. de The (1999). "Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins." Proceedings of the National Academy of Sciences of the United States of America 96(26): 14807-14812.

Lallemand-Breitenbach, V., M. Jeanne, S. Benhenda, R. Nasr, M. Lei, L. Peres, J. Zhou, J. Zhu, B. Raught and H. de The (2008). "Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway." Nature cell biology 10(5): 547-555.

Nasr, R., M. C. Guillemin, O. Ferhi, H. Soilihi, L. Peres, C. Berthier, P. Rousselot, M. Robledo-Sarmiento, V. Lallemand-Breitenbach, B. Gourmel, D. Vitoux, P. P. Pandolfi, C. Rochette-Egly, J. Zhu and H. de The (2008). "Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation." Nature medicine 14(12): 1333-1342.

Ablain, J., K. Rice, H. Soilihi, A. de Reynies, S. Minucci and H. de The (2014). "Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure." Nature Medicine 20(2): 167-174.

Lehmann-Che, J., C. Bally, E. Letouze, C. Berthier, H. Yuan, F. Jollivet, L. Ades, B. Cassinat, P. Hirsch, A. Pigneux, M. J. Mozziconacci, S. Kogan, P. Fenaux and H. de The (2018). "Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia." Nat Commun 9(1): 2047.

Wu, H. C., D. Rerolle, C. Berthier, R. Hleihel, T. Sakamoto, S. Quentin, S. Benhenda, C. Morganti, C. Wu, L. Conte, S. Rimsky, M. Sebert, E. Clappier, S. Souquere, S. Gachet, J. Soulier, S. Durand, J. J. Trowbridge, P. Benit, P. Rustin, H. El Hajj, E. Raffoux, L. Ades, R. Itzykson, H. Dombret, P. Fenaux, O. Espeli, G. Kroemer, L. Brunetti, T. W. Mak, V. Lallemand-Breitenbach, A. Bazarbachi, B. Falini, K. Ito, M. P. Martelli and H. de Thé (2021). "Actinomycin D targets NPM1c-primed mitochondria to restore PML-driven senescence in AML therapy." Cancer Discov 11:3198.

Bercier P, Wang QQ, Zang N, Zhang J, Yang C, Maimaitiyiming Y, Abou-Ghali M, Berthier C, Wu C, Niwa-Kawakita M, Dirami T, Geoffroy MC, Ferhi O, Quentin S, Benhenda S, Ogra Y, Gueroui Z, Zhou C, Naranmandura H, de The H*, Lallemand-Breitenbach V.* (2023) Structural basis of PML/RARA oncoprotein targeting by arsenic unravels a cysteine rheostat controlling PML body assembly and function. Cancer Discov. doi: 10.1158/2159-8290