Catharina Svanborg - Publications#

• Alternatively folded proteins with unexpected beneficial functions
• Comparison of Asymptomatic Bacteriuria Escherichia coli Isolates from Healthy Individuals versus Those from Hospital Patients Shows that Long-Term Bladder Colonization Selects for Attenuated Virulence Phenotypes
• Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire?
• HAMLET Forms Annular Oligomers When Deposited with Phospholipid Monolayers
• HAMLET: functional properties and therapeutic potential.
• Susceptibility to acute pyelonephritis or asymptomatic bacteriuria: Host-pathogen interaction in urinary tract infections.

• Acute pyelonephritis and renal scarring are caused by dysfunctional innate immunity in mCxcr2 heterozygous mice.
• Apoptosis-Like Death in Bacteria Induced by HAMLET, a Human Milk Lipid-Protein Complex
• Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis.
• Genetic control of the variable innate immune response to asymptomatic bacteriuria.
• Genetics of innate immunity and UTI susceptibility.
• HAMLET Binding to α-Actinin Facilitates Tumor Cell Detachment.
• MiR-129-5p is required for histone deacetylase inhibitor-induced cell death in thyroid cancer cells

• HAMLET Interacts with Lipid Membranes and Perturbs Their Structure and Integrity
• HAMLET Treatment Delays Bladder Cancer Development.
• HAMLET interacts with lipid membranes and perturbs their structure and integrity.
• Host Imprints on Bacterial Genomes-Rapid, Divergent Evolution in Individual Patients
• Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence.
• Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection.
• Structure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes.
• Toll-Like Receptor 4 Promoter Polymorphisms: Common TLR4 Variants May Protect against Severe Urinary Tract Infection.

• Changes in proteasome structure and function caused by HAMLET in tumor cells.
• Characterizing Escherichia coli asymptomatic bacteriuria (ABU) - what drives their successful silent colonization?
• HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death.
• Therapeutic Effect of Blocking CXCR2 on Neutrophil Recruitment and Dextran Sodium Sulfate-Induced Colitis
• Virulence properties of asymptomatic bacteriuria Escherichia coli alpha-Lactalbumin, Engineered to be Non-native and **Inactive, Kills Tumor Cells when in Complex with Oleic Acid: A new biological function resulting from partial unfolding.

• Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells).
• Asymptomatic Bacteriuria: An adaptive challenge for Escherichia coli within the urinary tract
• Can misfolded proteins be beneficial? The HAMLET case.
• Effects of epithelial and neutrophil CXCR2 on innate immunity and resistance to kidney infection.
• Molecular basis of commensalism in the urinary tract: low virulence or virulence attenuation?
• Pathogenomics: An updated European Research Agenda
• Shiga toxin-mediated disease in MyD88-deficient mice infected with Escherichia coli O157:H7.
• Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins
• TLR- and CXCR1-dependent innate immunity: insights into the genetics of urinary tract infections.

• A genetic basis of susceptibility to acute pyelonephritis.
• Bladder cancers respond to intravesical instillation of (HAMLET human alpha-lactalbumin made lethal to tumor cells).
• Ceramide as a TLR4 agonist; a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4.
• Do type 1 fimbriae promote inflammation in the human urinary tract?
• Fimbrial lectins influence the chemokine repertoire in the urinary tract mucosa.
• HAMLET, protein folding, and tumor cell death
• Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET.
• Inherited susceptibility to acute pyelonephritis: a family study of urinary tract infection.
• Reduced Toll-like receptor 4 expression in children with asymptomatic bacteriuria
• Urinary tract infections revisited.

• Glycolipid receptor depletion as an approach to specific antimicrobial therapy.
• HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53.
• Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets via TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome.
• Mechanism of pathogen-specific TLR4 activation in the mucosa: Fimbriae, recognition receptors and adaptor protein selection.
• Molecular characterization of the Escherichia coli asymptomatic bacteriuria strain 83972: The taming of a pathogen
• Uropathogenic Escherichia coli as a model of host-parasite interaction.
• alpha-Lactalbumin species variation, HAMLET formation, and tumor cell death.

• Compact oleic acid in HAMLET.
• Escherichia coli, fimbriae, bacterial persistence and host response induction in the human urinary tract.
• Expression of nitric oxide synthase isoforms in the mouse kidney: cellular localization and influence by lipopolysaccharide and Toll-like receptor 4.
• HAMLET kills tumor cells by apoptosis: Structure, cellular mechanisms, and therapy
• HAMLET; a novel tool to identify apoptotic pathways in tumor cells.
• Natural history of renal scarring in susceptible mIL-8Rh-/- mice.
• Neutrophil activation and renal scarring - Reply
• Stability of HAMLET--A kinetically trapped {alpha}-lactalbumin oleic acid complex.
• Urinary tract infections and the mucosal Immune system

• Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of alpha-lactalbumin
• Conformational analysis of HAMLET, the folding variant of human alpha-lactalbumin associated with apoptosis
• Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival.
• PapG-dependent adherence breaks mucosal inertia and triggers the innate host response
• Toll-like receptor 4 expression and cytokine responses in the human urinary tract mucosa.
• Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid
• Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid.
• Urinary tract infections as a model for innate mucosal immunity

• Analysis of genome plasticity in pathogenic and commensal Escherichia coli isolates by use of DNA arrays
• Der Einfluss von P-Fimbrien auf eine Leukozyturie und den Schwellenwert einer persistierenden Bakteriurie Effect of P fimbriae on pyuria and bacterial colonization of the human urinary tract
• Glycolipid depletion in antimicrobial therapy
• HAMLET interacts with histones and chromatin in tumor cell nuclei.
• HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects.
• Lipids as cofactors in protein folding: Stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells).
• The host response to urinary tract infection.
• alpha-Lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).

• Adhesion, signal transduction and mucosal inflammation
• Hamlet - A complex from human milk that induces apoptosis in tumor cells but spares healthy cells
• Hamlet--a complex from human milk that induces apoptosis in tumor cells but spares healthy cells.
• Human renal epithelial cells express iNOS in response to cytokines but not bacteria.
• The role of P fimbriae for Escherichia coli establishment and mucosal inflammation in the human urinary tract.

• A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria
• Carbohydrate receptor depletion as an antimicrobial strategy for prevention of urinary tract infection
• Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation
• Escherichia coli-induced inducible nitric oxide synthase and cyclooxygenase expression in the mouse bladder and kidney
• Fimbriae, transmembrane signaling, and cell activation
• Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephritis
• Neutrophil recruitment, chemokine receptors, and resistance to mucosal infection
• The 'innate' host response protects and damages the infected urinary tract
• The millenium symposium on pyelonephritis and urinary tract infection - Lund, Sweden, 24-26 May 2000 - Introduction
• Toll-like receptor signaling and chemokine receptor expression influence the severity of urinary tract infection
• Type 1 fimbriae deliver an LPS- and TLR4-dependent activation signal to CD14-negative cells
• Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo
• pap genotype and P fimbrial expression in Escherichia coli causing bacteremic and nonbacteremic febrile urinary tract infection

• Innate defences and resistance to gram negative mucosal infection
• Interleukin 8 receptor deficiency confers susceptibility to acute experimental pyelonephritis and may have a human counterpart
• Interleukin-8 receptor knockout mice have subepithelial neutrophil entrapment and renal scarring following acute pyelonephritis
• Transepithelial neutrophil migration is CXCR1 dependent in vitro and is defective in IL-8 receptor knockout mice

• Cytokine responses during mucosal infections: role in disease pathogenesis and host defence
• Macrophage inflammatory protein-2 is required for neutrophil passage across the epithelial barrier of the infected urinary tract
• Neutrophil recruitment and resistance to urinary tract infection

• Role of fimbriae-mediated adherence for neutrophil migration across Escherichia coli-infected epithelial cell layers

• Bacterial virulence in urinary tract infection
• Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration