Irene Bozzoni - Relevant recent publications:#

• FaziF., Rosa A., Fatica A., De Marchis M. L., Gelmetti V., Nervi C. and Bozzoni I. (2005) A mini-circuitry comprising microRNA-223 and transcription factors NFI-A and C/EBP regulates human granulopoiesis. Cell, 123: 819-831.

• DentiM.A., RosaA., D’AntonaG., SthandierO., De AngelisF.G., NicolettiC., AlloccaM., PansarasaO., ParenteV., MusaròA., AuricchioA., Bottinelli R. and BozzoniI. (2006) Body-wide gene therapy of Duchenne Muscular Dystrophy in the mdx mouse model. Proc. Natl. Acad. Sci. USA, 103: 3758-3763.

• Rosa A., Ballarino M., Sorrentino A., Sthandier O., De Angelis F.G., Marchioni M., Guarini A., Fatica A., Peschle C. and Bozzoni I. (2007) The interplay between the master transcription factor PU.1 and miR-424 regulates human monocytic differentiation, Proc. Natl. Acad. Sci. USA,104:19849-54.

• Morlando M., Ballarino M., Gromak N., Pagano F., Bozzoni I. and Proudfoot N. (2008) Primary microRNA transcripts are processed co-transcriptionally, Nat Struct. Mol. Biol., 15: 902 – 909.

• Incitti T., De Angelis F.G., Cazzella V., Sthandier O., Pinnarò C., Legnini I., and Bozzoni I. (2010) Exon skipping and Duchenne Muscular Dystrophy therapy: selection of the most active U1 snRNA-antisense able to induce dystrophin exon 51, Mol. Ther., 18:1675-82.

• Cacchiarelli D., Martone J., Girardi E., Cesana M., Incitti T., Nicoletti C., Santini T., Sthandier O., Auricchio A., Musarò A. & Bozzoni I.(2010).microRNAs Involved in Molecular Circuitries Relevant for the Duchenne Muscular Dystrophy Pathogenesis Are Controlled by the Dystrophin/nNOS Pathway.Cell Metabolism, 12:341-51

• Cacchiarelli D., Incitti T., Martone J., Cesana M., Cazzella V., Santini T., Sthandier O. and Bozzoni I. (2011) miR-31 modulates dystrophin expression: novel implications in Duchenne Muscular Dystrophy therapy. EMBO Rep., 12:136-41

• Cacchiarelli D., Legnini I.,Martone J., D’Amico A., Bertini E. and Bozzoni I. (2011) miRNAs as serum biomarkers for Duchenne Muscular Dystrophy. EMBO Mol Med., 5:258-265.

• Cesana M., Cacchiarelli D., Legnini I., Santini T., Sthandier O., Chinappi M., Tramontano A. and Bozzoni I. (2011) Key ceRNA role for the long non-codingRNA linc-MD1 in the control of muscle differentiation. Cell, 147: 358-369.

• Morlando M., Dini Modigliani S., Torrelli G., Rosa A., Di Carlo V., Caffarelli E. and Bozzoni I. (2012) FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment.EMBO J. 31:4502-10.

• Fatica A. and Bozzoni I. (2014) Long non-coding RNAs: new players in cell differentiation and development. Nature Review Genetics, 15:7-21

• Legnini I., Morlando M., Mangiavacchi A., Fatica A. and Bozzoni. I.. (2014)A feed forward regulatory loop between the HuR protein and the long non coding RNA linc-MD1 controls early phases of muscle differentiation. Mol. Cell, 53:1–9.