Eero Castrén - Selected Publications#
1. Casarotto P.C., Girych M., Fred S.M., Kovaleva, V., Moliner R., Enkavi G., Biojone C., Cannarozzo C., Sahu, M.P., Kaurinkoski, K., Brunello C.A., Steinzeig A., Winkel F., Patil S., Vestring S., Serchov T., Diniz C.R.A.F., Laukkanen L., Cardon I., Antila H., Rog T., Piepponen, T.P., Bramham C.R., Normann C., Lauri S.E., Saarma M., Vattulainen I., Castrén E. Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell 184, 1299–1313, https://doi.org/10.1016/j.cell.2021.01.034, 2021. (1 + 8 for BioRxiv version)
2. Lesnikova A., Casarotto P.C., Fred S.M., Voipio M, Winkel F., Steinzeig A., Antila H., Umemori J., Biojone C., and Castrén E. Chondroitinase and antidepressants promote plasticity by releasing TRKB from dephosphorylating control of PTPσ in parvalbumin neurons. J. Neurosci. 41(5):972-980. doi: 10.1523/JNEUROSCI.2228-20.2020, 2021. (1 citation)
3. Fred S.M., Laukkanen L., Vesa L., Goos H., Cardon I., Moliner R., Maritzen T., Varjosalo M., Casarotto P.C., and Castrén E. Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2. J. Biol. Chem. 294: 18150-18161. doi: 10.1074/jbc.RA119.008837, 2019. (5 citations)
4. Antila H., Ryazantseva M, Popova D., Sipilä P., Guirado R., Kohtala S., Yalcin I., Lindholm J., Vesa L., Sato V., Cordeira J., Autio H., Kislin M., Rios M., Joca S., Casarotto, P., Khiroug L,. Lauri S., Taira T., Castrén E.* and Rantamäki T.* Isoflurane produces antidepressant effects and induces TrkB signaling in rodents. *Shared corresponding authorship. Sci. Reports 10;7: 7811. doi: 10.1038/s41598-017-08166-9, 2017. (29 citations)
5. Mikics E., Guirado R., Umemori J., Tóth M., Biró L., Miskolczi C., Balázsfi D., Zelena D., Castrén E.*, Haller J., Karpova N.N. Social learning requires plasticity enhanced by fluoxetine through prefrontal Bdnf-TrkB signaling to limit aggression induced by post-weaning social isolation. Neuropsychopharmacology 43: 235-245. doi: 10.1038/npp.2017.142, 2018. *Corresponding author. (17 citations)
6. Castrén E., Antila H. Neuronal plasticity and neurotrophic factors in drug responses. Molecular Psychiatry, 22: 1085-1095, 2017. (71 citations)
7. Karpova N.N., Pickenhagen A., Lindholm J., Tiraboschi E., Kulesskaya N., Ágústsdóttir A., Antila H., Popova D., Akamine Y., Sullivan R., Hen R., Drew L.J. and Castrén E. Fear erasure in mouse requres synergy between antidepressant drug treatment and exposure therapy. Science 334:1731-1734, 2011. (230 citations)
8. Castrén E., and Hen, R.: Neuronal Plasticity and Antidepressant Effects. Trends Neurosci. 36: 259-267, 2013. (116 citations)
9. Maya Vetencourt JF, Sale A, Viegi A, Baroncelli L., De Pasquale R, O’Leary OF, Castrén E. and Maffei L. The antidepressant fluoxetine restores plasticity in the adult visual cortex. Science, 320, 385-388, 2008. (600 citations)
10. Saarelainen T., Hendolin P., Koponen E., Lucas G., MacDonald E., Agerman K., Haapasalo A., Nawa H., Ernfors P., Aloyz R. and Castrén E. Activation of the trkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J. Neurosci. 23 :349-357, 2003. (613 citations)
H-index: 63, citations 15,000 (Scopus)
