Dobromir Dobrev - Selected Publications#

Dobrev D, Heijman J, Hiram R, Li N, Nattel S (2022) Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology. Nat Rev Cardiol, 2022 Sep 15: 1–23. doi: 10.1038/s41569-022-00759-w.

Nattel S, Heijman J, Zhou L, Dobrev D (2020) The Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy: A Translational Perspective. Circ Res, 127: 51–72.

Heijman J et al. & Dobrev D (2020) Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Post-operative Atrial Fibrillation. Circ Res, 127(8): 1036-1055.

Dobrev D, et al. & Nattel S (2019) Post-operative Atrial Fibrillation: Mechanisms, Manifestations and Management. Nat Rev Cardiol, 16(7): 417-436.

Yao C, Veleva T et al. & Dobrev D, Li N (2018) Enhanced NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation. Circulation, 138: 2227–2242.

Heijman J, Voigt N, Nattel S, Dobrev D (2014) Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance and Progression. Circ Res, 114(9): 1483-99.

Dobrev D, Carlsson L, Nattel S (2012) Novel molecular targets for atrial fibrillation therapy. Nat Rev Drug Discov, 11(4): 275-91.

Voigt N, et al. & Dobrev D (2012) Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation, 125(17): 2059-70.

Dobrev D, Nattel S (2010) New antiarrhythmic drugs for treatment of atrial fibrillation. The Lancet, 375(9721): 1212-23.

Dobrev D, et al. & Ravens U (2005) The G-protein gated potassium current IK,ACh is constitutively active in patients with chronic atrial fibrillation. Circulation, 112: 3697-3706.