Haidong Kan - Selected Publications#

h-Index: 114 (Source: Google Scholar)
https://www.researchgate.net/profile/Haidong-Kan
PubMed search term: “Kan H”[Author]

1. Liu C, Chen R, Sera F, Vicedo-Cabrera AM, Guo Y, Tong S, Coelho MSZS, Saldiva PHN, Lavigne E, Matus P, Valdes Ortega N, Osorio Garcia S, Pascal M, Stafoggia M, Scortichini M, Hashizume M, Honda Y, Hurtado-Díaz M, Cruz J, Nunes B, Teixeira JP, Kim H, Tobias A, Íñiguez C, Forsberg B, Åström C, Ragettli MS, Guo YL, Chen BY, Bell ML, Wright CY, Scovronick N, Garland RM, Milojevic A, Kyselý J, Urban A, Orru H, Indermitte E, Jaakkola JJK, Ryti NRI, Katsouyanni K, Analitis A, Zanobetti A, Schwartz J, Chen J, Wu T, Cohen A, Gasparrini A, Kan H. Ambient Particulate Air Pollution and Daily Mortality in 652 Cities. N Engl J Med 2019; 381(8):705-715. (Notable Articles of 2019, a collection of articles selected by NEJM editors) [1139 citations]

First study to evaluate the relationship between ambient particulate matter and mortality at a global scale. The study findings provide key evidence for the World Health Organization to revise the PM2.5 recommended concentrations in the Global Air Quality Guidelines.

2. Liu Y, Ning Z, Chen Y, Guo M, Liu Y, Gali NK, Sun L, Duan Y, Cai J, Westerdahl D, Liu X, Xu K, Ho KF, Kan H* (* joint senior and corresponding author), Fu Q, Lan K. Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals. Nature 2020; 582(7813):557-560. [2270 citations]

First field work on the aerodynamic characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after the COVID-19 outbreak. The study findings provide evidence that COVID-19 can be transmitted through airborne aerosols.

3. Meng X, Liu C, Chen R, Sera F, Vicedo-Cabrera AM, Milojevic A, Guo Y, Tong S, Coelho MSZS, Saldiva PHN, Lavigne E, Correa PM, Ortega NV, Osorio S, Garcia, Kyselý J, Urban A, Orru H, Maasikmets M, Jaakkola JJK, Ryti N, Huber V, Schneider A, Katsouyanni K, Analitis A, Hashizume M, Honda Y, Ng CFS, Nunes B, Teixeira JP, Holobaca IH, Fratianni S, Kim H, Tobias A, Íñiguez C, Forsberg B, Åström C, Ragettli MS, Guo YL, Pan SC, Li S, Bell ML, Zanobetti A, Schwartz J, Wu T, Gasparrini A, Kan H. Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: multilocation analysis in 398 cities. BMJ 2021; 372: n534. [113 citations]

First study to examine the relationship between ambient nitrogen dioxide (NO2) and daily mortality at a global scale. The study findings provide evidence for the World Health Organization to revise the NO2 recommended concentrations in the Global Air Quality Guidelines.

4. Liu C, Chen R, Sera F, Vicedo-Cabrera AM, Guo Y, Tong S, Lavigne E, Correa PM, Ortega NV, Achilleos S, Roye D, Jaakkola JJ, Ryti N, Pascal M, Schneider A, Breitner S, Entezari A, Mayvaneh F, Raz R, Honda Y, Hashizume M, Ng CFS, Gaio V, Madureira J, Holobaca IH, Tobias A, Íñiguez C, Guo YL, Pan SC, Masselot P, Bell ML, Zanobetti A, Schwartz J, Gasparrini A, Kan H. Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis. BMJ 2023; 383:e075203. [8 citations]

First study to investigate interactive effects of fine particulate matter and ozone on daily mortality at a global level. The study findings suggest that policies and practices must account for the synergistic effects of different pollutants.

5. Chen R, Jiang Y, Hu J, Chen H, Li H, Meng X, Ji JS, Gao Y, Wang W, Liu C, Fang W, Yan H, Chen J, Wang W, Xiang D, Su X, Yu B, Wang Y, Xu Y, Wang L, Li C, Chen Y, Bell ML, Cohen AJ, Ge J, Huo Y, Kan H. Hourly Air Pollutants and Acute Coronary Syndrome Onset In 1.29 Million Patients. Circulation 2022; 145(24):1749-1760. [65 citations]

First nationwide study to show that transient (e.g. 1 hour) exposure to the air pollutants may trigger the onset of acute coronary syndrome, even at concentrations below the World Health Organization air quality guidelines.

6. Li H, Cai J, Chen R, Zhao Z, Ying Z, Wang L, Chen J, Hao K, Kinney PL, Chen H, Kan H. Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-blind, Crossover Trial of Air Purification. Circulation 2017; 136:618–627. [421 citations]

This randomized, double-blind crossover trial adds novel mechanistic insights into the adverse health outcomes associated with PM.

7. Lin Z, Chen R, Jiang Y, Xia Y, Niu Y, Wang C, Liu C, Chen C, Ge Y, Wang W, Yin G, Cai J, Clement V, Xu X, Chen B, Chen H, Kan H. Cardiovascular Benefits of Fish-Oil Supplementation Against Fine Particulate Air Pollution in China. J Am Coll Cardiol 2019; 73(16) : 2076-85. [136 citations]

This randomized, double-blinded, and placebo-controlled trial shows that omega-3 fatty acid supplementation is associated with short-term subclinical cardiovascular benefits against PM2.5 exposure. In areas with relatively heavy air pollution (e.g. China, India), the study findings provide a simple and effective way to protect health against hazardous exposure to PM2.5.

8. Chen R, Yin P, Wang L, Liu C, Niu Y, Wang W, Jiang Y, Liu Y, Liu J, Qi J, You J, Kan H* (* joint senior and corresponding author), Zhou MG. Association between ambient temperature and mortality risk and burden: time series study in 272 main Chinese cities. BMJ 2018; 363: k4306. [355 citations]

This nationwide study provides a comprehensive picture of the non-linear associations between ambient temperature and mortality, as well as the corresponding disease burden attributable to non-optimal temperatures in China. The findings on population vulnerability leads to policy changes of Chinese government.

9. He C, Kim H, Hashizume M, Lee W, Honda Y, Kim SE, Kinney PL, Schneider A, Zhang Y, Zhu Y, Zhou L, Chen R, Kan H. The effects of night-time warming on mortality burden under future climate change scenarios: a modelling study. Lancet Planet Health 2022; 6(8):e648-e657. [43 citations]

First multi-country study to explore the impact of hot nights on mortality. The study findings contribute to formulation of related adaptation measures.

10. Zhu Y, He C, Bell M, Zhang Y, Fatmi Z, Zhang Y, Zaid M, Bachwenkizi J, Liu C, Zhou L, Chen R, Kan H. Association of Ambient Temperature With the Prevalence of Intimate Partner Violence Among Partnered Women in Low- and Middle-Income South Asian Countries. JAMA Psychiatry 2023, e231958. [1 citation]

First multi-country study in developing world to examine the relationship between ambient temperature and intimate partner violence (IPV). The study findings highlight the vulnerabilities and inequalities of women experiencing IPV in developing countries in the context of global climate warming.