Karikó Katalin - Selected Publications#

1. Karikó, K., Ni, H., Capodici, J., Lamphier, M., and Weissman, D. (2004) mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 279, 12542-12550 cited: 1,068

2. Karikó, K., Buckstein, M., Ni, H., and Weissman, D. (2005) Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23, 165-175 cited: 995

3. Karikó, K., Muramatsu, H., Welsh, F. A., Ludwig, J., Kato, H., Akira, S., and Weissman, D. (2008) Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Mol Ther 16, 1833-1840 cited: 577

4. Karikó, K., Muramatsu, H., Ludwig, J., and Weissman, D. (2011) Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA. Nucleic acids research 39, e142 cited: 330

5. Karikó, K., Muramatsu, H., Keller, J. M., and Weissman, D. (2012) Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridine-containing mRNA encoding erythropoietin. Mol Ther 20, 948-953 cited: 245

6. Pardi, N., Hogan, M. J., Pelc, R. S., Muramatsu, H., Andersen, H., DeMaso, C. R., Dowd, K. A., Sutherland, L. L., Scearce, R. M., Parks, R., Wagner, W., Granados, A., Greenhouse, J., Walker, M., Willis, E., Yu, J. S., McGee, C. E., Sempowski, G. D., Mui, B. L., Tam, Y. K., Huang, Y. J., Vanlandingham, D., Holmes, V. M., Balachandran, H., Sahu, S., Lifton, M., Higgs, S., Hensley, S. E., Madden, T. D., Hope, M. J., Karikó, K., Santra, S., Graham, B. S., Lewis, M. G., Pierson, T. C., Haynes, B. F., and Weissman, D. (2017) Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination. Nature 543, 248-251 cited: 377

These 6 papers provided the foundation for mRNA-based anti-SARS-CoV-2 vaccines developed by BioNTech/Pfizer and Moderna/NIH.