José López-Barneo - Selected publications#

1. López-Barneo J, Darlot C, Berthoz A, Baker R. Neuronal activity in the prepositus nucleus correlated with eye movements in the alert cat. Journal of Neurophysiology 1981; 47: 329-352.

2. López-Barneo J, Armstrong CM. Depolarizing response of rat parathyroid cells to divalent cations. Journal of General Physiology 1983; 82: 269-294.

3. Armstrong CM, López-Barneo J. External calcium ions are required for potassium channel gating in squid neurons. Science 1987; 236: 712-714. 4. Alvarez de Toledo G, López-Barneo J. Ionic basis of the differential neuronal activity of guinea pig septal nucleus studied "in vitro". Journal of Physiology 1988; 396: 399-415.

5. López-Barneo J, López-López J, Ureña J, González, C. Chemotransduction in the carotid body: potassium current modulated by pO2 in type I chemoreceptor cells. Science 1988; 241: 580-582.

6. López-Barneo J, Llinás R. Electrophysiology of mammalian tectal neurons "in vitro". I. Transient ionic conductances. Journal of Neurophysiology 1988; 60: 853-868.

7. López-López J, González C, Ureña J, López-Barneo J. Low pO2 selectively inhibits K+ channel activity in chemoreceptor cells of the mammalian carotid body. Journal of General Physiology 1989; 93: 1001-1015.

8. López-Barneo J, Castellano J, Toledo-Aral J. Tyrotropin-releasing-hormone and its physiological derivative TRH-OH inhibit Na+ channel activity in septal neurons. Proceedings of the National Academy of Sciences (USA) 1990; 87: 8150-8154.

9. Ganfornina MD, López-Barneo J. Single K+ channels in membrane patches of arterial chemoreceptor cells are modulated by O2 tension. Proceedings of the National Academy of Sciences (USA). 1991; 88: 2927-2930.

10. Ganfornina MD, López-Barneo J. Potassium channel types in arterial chemoreceptor cells and their selective modulation by oxygen. Journal of General Physiology 1992; 100: 401-426.

11. López-Barneo J, Hoshi T, Heinemann S, Aldrich RW. Effect of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors and Channels 1993; 1: 61-71.

12. Ureña J, Fernández-Chacón R, Benot A, Alvarez de Toledo G, López-Barneo J. Hypoxia induces voltagedependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells. Proceedings of the National Academy of Sciences (USA) 1994; 91:10208-10211.

13. Franco-Obregón A, Ureña J, López-Barneo J. Oxygen-sensitive calcium channels in vascular smooth muscle and their possible role in hypoxic arterial relaxation. Proceedings of the National Academy of Sciences (USA) 1995; 92: 4715-4719.

14. Montoro R, Ureña J, Fernández-Chacón R, Alvarez de Toledo G, López-Barneo J. O2-sensing by ion channels and chemotransduction in single glomus cells. Journal of General Physiology 1996; 107: 133-143.

15. Franco-Obregón A, López-Barneo J. Differential oxygen-sensitivity of calcium channels in smooth muscle cells of conduit and resistance pulmonary arteries. Journal of Physiology 1996; 491: 511-518.

16. López-Barneo J. O2-sensing by ion channels and the regulation of cellular functions. Trends in Neurosciences 1996; 19: 435-440.

17. Molina J, Castellano A, López-Barneo J. Pore mutations in Shaker K+ channels distinguish between the sites of TEA blockade and C-type inactivation. Journal of Physiology 1997; 499: 361-367.

18. Castellano A, Chiara MD, Mellström B, Molina A, Monje F, Naranjo JR, López-Barneo J. Identification and functional characterization of a K+ channel a-subunit with regulatory properties specific of brain. The Journal of Neuroscience 1997; 17: 4652-4661.

19. Espejo EF, Montoro RJ, Armengol JA, López-Barneo J. Cellular and functional recovery of parkinsonian rats after intrastriatal transplantation of carotid body cell aggregates. Neuron 1998; 20: 197-206.

20. Luquin R, Montoro R, Guillén J, Saldise L, Insausti R, del Río J, López-Barneo J. Recovery of chronic parkinsonian monkeys after autotransplants of carotid body cell aggregates. Neuron 1999; 22: 743-750.

21. Pardal R, Ludewig U, García-Hirschfeld J, López-Barneo J. Secretory responses to hypoxia and tetraethylammonium of intact glomus cells in thin slices of rat carotid body. Proceedings of the National Academy of Sciences (USA) 2000; 97: 2361-2366.

22. Ortega-Sáenz P, Pardal R, Castellano A, López-Barneo J. Collapse of conductance is prevented by a glutamate residue conserved in voltage-gated K+ channels. Journal of General Physiology 2000; 116: 181-190.

23. López-Barneo J, Pardal R, Ortega-Sáenz P. Cellular mechanisms of oxygen-sensing. Annual Review of Physiology 2001; 63:259-287.

24. Pardal R, López-Barneo J. Low glucose-sensing cells in the carotid body. Nature Neuroscience 2002; 5: 197- 198.

25. Toledo-Aral J, Méndez-Ferrer S, Pardal R, Echevarría M, López-Barneo J. Throfic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body grafted parkinsonian rats. The Journal of Neuroscience 2003; 23: 141-148.

26. Ortega-Sáenz P, Pardal R, García-Fernández M, López-Barneo, J. Rotenone selectively blocks sensitivity to hypoxia in rat carotid body glomus cells. Journal of Physiology 2003; 548: 789-800.

27. del Toro R, Levitsky C, López-Barneo J, Chiara MD. Induction of T-type calcium channel gene expression by chronic hypoxia. Journal of Biological Chemistry 2003; 278: 22316-22324.

28. Arjona V, Mínguez-Castellanos A, Montoro RJ, Ortega A, Escamilla F, Toledo-Aral JJ, Pardal R, Méndez- Ferrer S, Martín JM, Pérez M, Katati MJ, Valencia E, García T, López-Barneo J. Autotransplantation of carotid body cell aggregates for treatment of Parkinson's disease. Neurosurgery 2003; 53:321-330.

29. López-Barneo J. Oxygen and glucose sensing by carotid body cells. Current Opinion in Neurobiology 2003; 13: 493-499.

30. Del Valle-Rodríguez A, López-Barneo J, Ureña J. Ca2+ channel-sarcoplasmic reticulum coupling: a mechanism of arterial myocyte contraction without Ca2+ influx. EMBO Journal 2003; 22: 4337-4345.

31. Piruat J, Pintado CO, Ortega-Sáenz P, Roche M, López-Barneo J. The mitochondrial SDHD gene is required for early embryogenesis and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to hypoxia. Molecular and Cellular Biology 2004; 24: 10933-10940.

32. Villadiego J, Méndez-Ferrer S, Valdés-Sánchez T, Silos-Santiago I, Fariñas I, López-Barneo J, Toledo-Aral JJ. Selective glial cel line-derived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation. The Journal of Neuroscience 2005; 25: 4091-4098.

33. Muñoz-Cabello A, Toledo-Aral JJ, López-Barneo J, Echevarría M. Rat adrenal chromaffin cells are neonatal CO2 sensors. The Journal of Neuroscience 2005; 25: 6631-6640.

34. Navarro-Antolín, J, Levitsky KL, Calderón E, Ordóñez A, López-Barneo J. Decreased expression of maxi-K+ channel b1 subunit and altered vasoregulation in hypoxia. Circulation 2005; 112: 1309-1315.

35. Weir EK, López-Barneo J, Buckler K, Archer S. Acute Oxygen Sensing. New England Journal of Medicine 2005; 353: 1042-1055.

36. del Valle-Rodríguez A, Calderón E, Ruiz M, Ordoñez A, López-Barneo J, Ureña, J. Metabotropic Ca2+- channel induced Ca2+ release and ATP-dependent facilitation of arterial myocyte contraction. Proceedings of the National Academy of Sciences (USA) 2006; 103: 4316-4321.

37. Mejías R, Villadiego J, Pintado CO, Vime PJ, Gao L, Toledo-Aral J, Echevarría M, López-Barneo, J. Neuroprotection by transgenic expression of glucose-6-phosphate dehydrogenase in dopaminergic nigrostriatal neurons of mice. The Journal of Neuroscience 2006; 26: 4500-4508.

38. Ortega-Sáenz P, Pascual A, Gómez R, López-Barneo J. Acute oxygen sensing in heme oxygenase-2 null mice. The Journal of General Physiology 2006;128: 405-411.

39. Minguez-Castellanos A, Escamilla-Sevilla F, Hotton GR, Toledo-Aral JJ, Ortega-Moreno A, Mendez-Ferrer S, Martin-Linares JM, Katati MJ, Mir P, Villadiego J, Meersmans M, Perez-Garcia M, Brooks DJ, Arjona V, López-Barneo J. Carotid body autotransplantation in Parkinson disease: A clinical and PET study. Journal of Neurology, Neurosurgery and Psychiatry, 2007; 78: 825-831.

40. Echevarría M, Muñoz-Cabello A M, Sánchez-Silva R, Toledo-Aral JJ, López-Barneo J. Development of cytosolic hypoxia and HIF stabilization are facilitated by aquaporin-1 expression. Journal of Biological Chemistry 2007; 282:30207-30215.

41. Pardal R, Ortega-Sáenz P, Duran R, López-Barneo J. Glia-like stem cells sustain physiologic neurogenesis in the adult carotid body. Cell 2007;131:364-377.

42. García-Fernández M, Ortega-Sáenz P, Castellano A, López-Barneo J. Mechanisms of low-glucose sensitivity in carotid body cells. Diabetes 2007; 56:2893-2900.

43. Pascual A, Hidalgo-Figueroa M, Piruat JI, Pintado CO, Gómez-Díaz R, López-Barneo J. Absolute requirement of GDNF for adult catecholaminergic neuron survival. Nature Neuroscience, 2008; 11:755-761.

44. Levitsky KL, López-Barneo J. Developmental change of T-type Ca2+ channel expression and its role in rat chromaffin cell responsiveness to acute hypoxia. Journal of Physiology, 2009; 587:1917-1929.

45. Fernández-Tenorio M, González-Rodríguez P, Porras C, Castellano A, Moosmang S, Hofmann F, Ureña J, López-Barneo J. Genetic ablation of L-type Ca2+ channels abolishes depolarization-induced Ca2+ release in arterial smooth muscle. Circulation Research, 2010; 106: 1285-1289.

46. Ortega-Sáenz P, Levitsky KL, Marcos-Almaraz MT, Bonilla-Henao V, Pascual A, López-Barneo J. Carotid body chemosensory responses in mice deficient of TASK channels. Journal of General Physiology, 2010; 135: 379-392.

47. Fernández-Tenorio M, Porras-González C, Castellano A, Del Valle-Rodríguez A, López-Barneo J, Ureña J. Metabotropic regulation of RhoA/Rho-associated kinase by L-type Ca2+ channels: new mechanism for depolarization-evoked mammalian arterial contraction. Circulation Research, 2011;108(11):1348-1357.

48. Hidalgo-Figueroa* M, Bonilla* S, Gutiérrez F, Pascual A, López-Barneo J. GDNF is predominantly expressed in the PV+ neostriatal interneuronal ensemble in normal mouse and after injury of the nigrostriatal pathway. The Journal of Neuroscience, 2012, 32:864-87.

49. Romero-Ruiz A, Bautista L, Navarro V, Heras-Garvín A, March-Díaz R, Castellano A, Gómez-Díaz R, Castro MJ, Berra E, López-Barneo J, Pascual A. Prolyl hydroxylase-dependent modulation of eukaryotic elongation factor 2 activity and protein translation under acute hypoxia. Journal of Biological Chemistry. 2012, 287(12):9651-8.

50. Sánchez-Danés A, Richaud-Patin Y, Carballo-Carbajal I, Jiménez-Delgado S, Caig C, Mora S, Di Guglielmo C, Ezquerra M, Patel B, Giralt A, Canals JM, Memo M, Alberch J, López-Barneo J, Vila M, Cuervo AM, Tolosa E, Consiglio A, Raya A. Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease. EMBO Mol Med. 2012 Mar 8. doi: 10.1002/emmm.201200215.