Bart Lambrecht - Selected Publications#
1. Establishing a role for the airway epithelium and airway structural cells in actively shaping the outcome of adaptive immunity by influencing the phenotype and function of dendritic cells.
a. House dust mite allergen induces asthma via TLR4 triggering of airway structural cells. Hammad H, Chieppa M, Perros F, Willart M, Germain RN, Lambrecht B.N. Nature Medicine 2009 15:410-416. (669 Web of Science citations).
b. Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells M J. Schuijs, M A. Willart, K Vergote, D Gras, K Deswarte, M J. Ege, F Branco Madeira, R Beyaert, G van Loo, F Bracher, E von Mutius, P Chanez, B.N. Lambrecht, H. Hammad, Science, 2015 Sept 349(6252): 1106-1110 (shared last authorship; 210 Web of Science citations). Paper later highlighted by a 3 page piece in New England Journal of Medicine “Clinical Implications of Basic Research”
c. Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. Willart MA, Deswarte K, Pouliot P, Braun H, Beyaert R, Lambrecht BN, Hammad H. J Exp Med. 2012 Jul 30;209(8):1505-17.
2. Identification and characterization of specific dendritic cell subsets which support distinct adaptive immune responses.
a. Conventional and Monocyte-Derived CD11b(+) Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen. Plantinga M, Guilliams M, Vanheerswynghels M, Deswarte K, Branco-Madeira F, Toussaint W, Vanhoutte L, Neyt K, Killeen N, Malissen B, Hammad H, Lambrecht B.N. Immunity. 2013 Feb 21;38(2):322-35. (411 Web of Science citations)
b. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. De Heer HJ, Hammad H, Souillie T, Hijdra D, Vos N, Willart MAM, Hoogsteden HC, Lambrecht B.N. J. Exp. Med 2004; 200:89-98 (562 Web of Science citations)
c. Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species. Guilliams M, Dutertre CA, Scott CL, McGovern N, Sichien D, Chakarov S, Van Gassen S, Chen J, Poidinger M, De Prijck S, Tavernier SJ, Low I, Irac SE, Mattar CN, Sumatoh HR, Low GHL, Chung TJK, Chan DKH, Tan KK, Hon TLK, Fossum E, Bogen B, Choolani M, Chan JKY, Larbi A, Luche H, Henri S, Saeys Y, Newell EW, Lambrecht B.N.*, Malissen B*, Ginhoux F*. Immunity. 2016 Sep 20;45(3):669-684. (*Shared last authorship, 198 Web of Science Citations)
d. Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection. Bosteels C, Neyt K, Vanheerswynghels M, van Helden MJ, Sichien D, Debeuf N, De Prijck S, Bosteels V, Vandamme N, Martens L, Saeys Y, Louagie E, Lesage M, Williams DL, Tang S-C, Mayer JU, Ronchese F, Scott CL, Hammad H, Guilliams M, Lambrecht B.N. Immunity. 2020 June 16; 52 (6), 1039–1056.
3. Defining the molecular and cellular basis of type 2 immunity and elucidating the mechanisms of action of various type 2 stimuli.
a. Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells. Tibbitt CA, Stark JM, Martens L, Ma J, Mold JE, Deswarte K, Oliynyk G, Feng X, Lambrecht B.N, De Bleser P, Nylén S, Hammad H, Arsenian Henriksson M, Saeys Y, Coquet JM. Immunity. 2019 Jul 16;51(1):169-184.
b. Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites. Coquet JM, Schuijs MJ, Smyth MJ, Deswarte K, Beyaert R, Braun H, Boon L, Karlsson Hedestam GB, Nutt SL, Hammad H, Lambrecht B.N. Immunity. 2015 Aug 18;43(2):318-30
c. Protein crystallization promotes type 2 immunity and is reversible by antibody treatment. Persson EK, Verstraete K, Heyndrickx I, Gevaert E, Aegerter H, Percier JM, Deswarte K, Verschueren KHG, Dansercoer A, Gras D, Chanez P, Bachert C, Gonçalves A, Van Gorp H, De Haard H, Blanchetot C, Saunders M, Hammad H, Savvides SN, Lambrecht B.N. Science. 2019;364. Paper recently covered by a 3 page piece in New England Journal of Medicine “Clinical Implications of Basic Research”
d. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. Kool M, Souillié T, Willart M, Jung S, Henk C. Hoogsteden, Hammad H, Lambrecht B.N J. Exp. Med. 2008, 205:869-882. (579 Web of Science citations)
Complete List of Published Work in Publons.
http://www.researcherid.com/rid/K-2484-2014
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