Cato Laurencin - Papers and Patents#

Nanofiber Technologies

Dr. Laurencin’s seminal patent and paper inspired the development of the field of polymeric nanofibers for biomedical use.

1. Li, Wan-Ju, Laurencin, C.T., Caterson, E.J., Tuan, R. S., Ko, F.K. (2002). Electrospun nanofibrous structure: A novel scaffold for tissue engineering. J. Biomed. Mater. Res. 60, 613-621.
DOI: https://doi.org/10.1002/jbm.10167

2. Laurencin, C.T., Ko, F.K.: Hybrid nanofibril matrices for use as tissue engineering devices. U.S. Patent No. 6,689,166

Degradable Biocompatible Polymers for Musculoskeletal Use

Dr. Laurencin’s work on a sintered polymeric microsphere matrix inspired the development of the Microfuse Bone Matrix for bone repair, used in surgical procedures worldwide, and the development of polymer based bone regeneration in general.

3. Borden, M.D., Attawia, M.A., Khan, Y., El-Amin, S., Laurencin, C.T. (2004). Tissue Engineered Bone Formation In Vivo Using a Novel Sintered Polymeric Microsphere Matrix. Journal of Bone and Joint Surgery, Br 86-B, 1200-1208.
DOI: https://doi.org/10.1302/0301-620X.86B8.14267

4. Yu X, Botchwey EA, Levine EM, Pollack SR, Laurencin CT. (2004). Bioreactor- based bone tissue engineering: The influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization. Proc Natl Acad Sci 101,1203-8.
DOI: https://doi.org/10.1073/pnas.0402532101

Polymer-Ceramic Composites

Dr. Laurencin pioneered the study and development of composites of polymers and ceramics, as well as polymers and allografts. His work inspired biocomposite polymer-ceramic screws and commercial polymer- allograft products.

5. Ambrosio, A.A., Sahota, J.S., Khan, M.Y., Laurencin, C.T. (2001). A novel amorphous calcium phosphate ceramic for bone repair. I. Synthesis and Characterization. J. Biomed Mater. Res. 58, 295-301.
DOI: https://doi.org/10.1002/1097-4636 (2001)58:3<295::AID-JBM1020>3.0.CO;2-8

6. Arnold, A., Holt, B., Daneshmandi, L., Laurencin, C.T., Sydlik, S.A. (2019). Phosphate graphene as an intrinsically osteoinductive scaffold for stem cell-driven bone regeneration. Proc Natl Acad Sci. 116(11):4855-4860.
DOI: https://doi.org/10.1073/pnas.1815434116

Polyphosphazenes

Working with Dr. Harry Allcock, Dr. Laurencin designed a broad class of biocompatible and biodegradable polymers. He was responsible for elucidating the mechanisms of degradation and biocompatibility.

7. Ogueri Kenneth S, Escobar Ivirico Jorge L, Li Zhongjing, Blumenfield Riley H, Allcock Harry R, Laurencin Cato T. (2019). Synthesis, Physicochemical Analysis, and Side Group Optimization of Degradable Dipeptide-Based Polyphosphazenes as Potential Regenerative Biomaterials. American Chemical Society Applied Polymer Materials 1, 6, 1568-1578
DOI: https://doi.org/10.1021/acsapm.9b00333

Polymers for Soft Tissue Regeneration

Dr. Laurencin pioneered the development of the bioengineered degradable polymer fiber matrix for the ACL the first to successfully used in humans. His work also has focused on pioneering polymeric materials for shoulder regeneration based on his nanofiber technology.

8. Cooper JA Jr, Sahota JS, Gorum WJ 2nd, Carter J, Doty SB, Laurencin CT. (2007). Biomimetic tissue-engineered anterior cruciate ligament replacement. Proc Natl Acad Sci. Feb 27; 104(9):3049- 54.
DOI: https://doi.org/10.1073/pnas.0608837104

Regenerative Engineering

Dr. Laurencin has pioneered a new field, Regenerative Engineering, described as the Convergence of areas such as nano-materials science. He recently received the Founders Award from the National Academy of Engineering in large part for his work in this field. His work has uncovered signaling molecules for tissue regeneration and he has created a new class of stem cells: synthetic artificial stem cells (SASC), published in the Proceedings of the National Academy of Sciences.

9. Cushnie, E. K., Ulery, B. Nelson, S.J., Deng, M. Sethuraman, S., Doty, S.B., Lo, K.W.H., Khan, Y., Laurencin, C.T. (2014) Simple Signaling Molecules for Inductive Regenerative Engineering. PLoS ONE 9, e101627. https://doi.org/10.1371/journal.pone.01016272014

10. Shah, S. Esdaille, C.J., Bhattacharjee, M., Kan, H.M. and Laurencin, C.T.: (2022) The synthetic artificial stem cell (SASC): Shifting the paradigm of cell therapy in regenerative engineering. Proceedings of the National Academy of Sciences 119 (2) e2116865118 | https://doi.org/10.1073/pnas.2116865118