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Lorenzo Moretta - Selected publications#


  • Increased natural cytotoxicity receptor expression and relevant IL10 production in NK cells from chronically infected viremic HCV patients. De Maria A, Fogli M, Mazza S, Basso M, Picciotto A, Costa P, Congia S, Mingari MC, Moretta L. Eur J Immunol. 2007 Feb;37(2):44555.
  • Killer immunoglobulinlike receptors. Moretta L, Moretta A. Curr Opin Immunol. 2004 Oct;16(5):62633. Review.
  • Functional characterization of natural killer cells in type I leukocyte adhesion deficiency. Castriconi R, Dondero A, Cantoni C, Della Chiesa M, Prato C, Nanni M, Fiorini M, Notarangelo L, Parolini S, Moretta L, Notarangelo L, Moretta A, Bottino C. Blood. 2007 Feb 1; Epub ahead of print
  • Effector and regulatory events during natural killerdendritic cell interactions. Moretta L, Ferlazzo G, Bottino C, Vitale M, Pende D, Mingari MC, Moretta A. Immunol Rev. 2006 Dec;214:21928. Review.
  • Multidirectional interactions are bridging human NK cells with plasmacytoid and monocytederived dendritic cells during innate immune responses. Della Chiesa M, Romagnani C, Thiel A, Moretta L, Moretta A. Blood. 2006 Dec 1;108(12):38518.
  • Analysis of natural killercell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc134 defect and discriminates between genetic subtypes of the disease. Marcenaro S, Gallo F, Martini S, Santoro A, Griffiths GM, Arico M, Moretta L, Pende D. Blood. 2006 Oct 1;108(7):231623.
  • NK receptors and their ligands on tumor cells. Moretta L, Bottino C, Pende D, Castriconi R, Mingari MC, Moretta A. Surface Semin Immunol. 2006 Jun;18(3):1518. Review.
  • Comparison of different CpG oligodeoxynucleotide classes for their capability to stimulate human NK cells. Sivori S, Carlomagno S, Moretta L, Moretta A. Eur J Immunol. 2006 Apr;36(4):9617.
  • NK cell activating receptors and tumor recognition in humans. Bottino C, Moretta L, Moretta A. Curr Top Microbiol Immunol. 2006;298:17582. Review.
  • Mesenchymal stem cellnatural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL2induced NKcell proliferation. Spaggiari GM, Capobianco A, Becchetti S, Mingari MC, Moretta L. Blood. 2006 Feb 5;107(4):148490.
  • Early liaisons between cells of the innate immune system in inflamed peripheral tissues. Moretta A, Marcenaro E, Sivori S, Della Chiesa M, Vitale M, Moretta L. Trends Immunol. 2005 Dec;26(12):66875. Epub 2005 Sep 28. Review.
  • Human natural killer cells: Molecular mechanisms controlling NK cell activation and tumor cell lysis. Moretta L, Bottino C, Pende D, Vitale M, Mingari MC, Moretta A. Immunol Lett. 2005 Aug 15;100(1):713. Review.
  • Activation of human NK cells by plasmacytoid dendritic cells and its modulation by CD4+ T helper cells and CD4+ CD25hi T regulatory cells. Romagnani C, Della Chiesa M, Kohler S, Moewes B, Radbruch A, Moretta L, Moretta A, Thiel A. Eur J Immunol. 2005 Aug;35(8):24528.
  • Cellular ligands of activating NK receptors. Bottino C, Castriconi R, Moretta L, Moretta A. Trends Immunol. 2005 Apr;26(4):2216. Review.
  • NKdependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor. Vitale M, Della Chiesa M, Carlomagno S, Pende D, Arico M, Moretta L, Moretta A. Blood. 2005 Jul 15;106(2):56671.
  • IL12 or IL4 prime human NK cells to mediate functionally divergent interactions with dendritic cells or tumors. Marcenaro E, Della Chiesa M, Bellora F, Parolini S, Millo R, Moretta L, Moretta A. J Immunol. 2005 Apr 1;174(7):39928.
  • PVR (CD155) and Nectin2 (CD112) as ligands of the human DNAM1 (CD226) activating receptor: involvement in tumor cell lysis. Pende D, Bottino C, Castriconi R, Cantoni C, Marcenaro S, Rivera P, Spaggiari GM, Dondero A, Carnemolla B, Reymond N, Mingari MC, Lopez M, Moretta L, Moretta A. Mol Immunol. 2005 Feb;42(4):4639.
  • Natural killer cellmediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule1poliovirus receptor interaction. Castriconi R, Dondero A, Corrias MV, Lanino E, Pende D, Moretta L, Bottino C, Moretta A. Cancer Res. 2004 Dec 15;64(24):91804.
  • Analysis of the receptorligand interactions in the natural killermediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin2 (CD112). Pende D, Spaggiari GM, Marcenaro S, Martini S, Rivera P, Capobianco A, Falco M, Lanino E, Pierri I, Zambello R, Bacigalupo A, Mingari MC, Moretta A, Moretta L. Blood. 2005 Mar 1;105(5):2066-
73.
  • Different checkpoints in human NKcell activation. Moretta L, Bottino C, Pende D, Vitale M, Mingari MC, Moretta A. Trends Immunol. 2004 Dec;25(12):6706. Review.
  • Identification of 4IgB7H3 as a neuroblastomaassociated molecule that exerts a protective role from an NK cellmediated lysis. Castriconi R, Dondero A, Augugliaro R, Cantoni C, Carnemolla B, Sementa AR, Negri F, Conte R, Corrias MV, Moretta L, Moretta A, Bottino C. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):126405.
  • Learning how to discriminate between friends and enemies, a lesson from Natural Killer cells. Bottino C, Moretta L, Pende D, Vitale M, Moretta A. Mol Immunol. 2004 Jul;41(67):56975. Review.
  • CpG and doublestranded RNA trigger human NK cells by Tolllike receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells. Sivori S, Falco M, Della Chiesa M, Carlomagno S, Vitale M, Moretta L, Moretta A. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):1011621.
  • The small subset of CD56brightCD16natural killer cells is selectively responsible for both cell proliferation and interferongamma production upon interaction with dendritic cells. Vitale M, Della Chiesa M, Carlomagno S, Romagnani C, Thiel A, Moretta L, Moretta A. Eur J Immunol. 2004 Jun;34(6):171522.
  • Moretta L, Moretta A. Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J. 2004 Jan 28;23(2):2559. Review.
  • Sivori S, Cantoni C, Parolini S, Marcenaro E, Conte R, Moretta L, Moretta A. IL- 21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Iglike receptors. Eur J Immunol. 2003 Dec;33(12):3439 47.
  • Marcenaro E, Augugliaro R, Falco M, Castriconi R, Parolini S, Sivori S, Romeo E, Millo R, Moretta L, Bottino C, Moretta A. CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cellmediated cytotoxicity. Eur J Immunol. 2003 Dec;33(12):336776.
  • Moretta L, Bottino C, Ferlazzo G, Pende D, Melioli G, Mingari MC, Moretta A. Surface receptors and functional interactions of human natural killer cells: from bench to the clinic. Cell Mol Life Sci. 2003 Oct;60(10):213946. Review.
  • Moretta L, Ferlazzo G, Mingari MC, Melioli G, Moretta A. Update on natural killer cells: crosstalk with dendritic cells and role in the cure of acute myeloid leukemias. Cancer J. 2003 JulAug;9(4):2327. Review.
  • De Maria A, Fogli M, Costa P, Murdaca G, Puppo F, Mavilio D, Moretta A, Moretta L. The impaired NK cell cytolytic function in viremic HIV1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44). Eur J Immunol. 2003 Sep;33(9):24108.
  • Moretta L, Mingari MC, Bottino C, Pende D, Biassoni R, Moretta A. Cellular and molecular basis of natural killer and natural killerlike activity. Immunol Lett. 2003 Aug 5;88(2):8993. Review.
  • Della Chiesa M, Vitale M, Carlomagno S, Ferlazzo G, Moretta L, Moretta A. The natural killer cellmediated killing of autologous dendritic cells is confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer Iglike receptors. Eur J Immunol. 2003 Jun;33(6):165766. Erratum in: Eur J Immunol. 2003
Oct;33(10):2947.
  • Moretta L, Ferlazzo G, Mingari MC, Melioli G, Moretta A. Human natural killer cell function and their interactions with dendritic cells. Vaccine. 2003 Jun 1;21 Suppl 2:S3842. Review.
  • Castriconi R, Cantoni C, Della Chiesa M, Vitale M, Marcenaro E, Conte R, Biassoni R, Bottino C, Moretta L, Moretta A. Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NKmediated killing of dendritic cells. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):41205.
  • Moretta L, Romagnani C, Pietra G, Moretta A, Mingari MC. NKCTLs, a novel HLAErestricted Tcell subset. Trends Immunol. 2003 Mar;24(3):13643. Review.
  • Ferlazzo G, Morandi B, D'Agostino A, Meazza R, Melioli G, Moretta A, Moretta L. The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells. Eur J Immunol. 2003 Feb;33(2):30613.


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