Jaakko Tuomilehto - Selected Publications#

1. Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M, for the Finnish Diabetes Prevention Study Group. Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance. N Engl J Med 2001; 344: 1343-50.

2. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MJ, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding C-J, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li X-Y, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M. A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants. Science 2007; 316: 1341-5.

3. Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. A 2-year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet 2015; 385: 2255-63.

4. Taylor DL, Jackson AU, Narisu N, Hemani G, Erdos MR, Chines PS, Swift A, Idol J, Didion JP, Welch RP, Kinnunen L, Saramies J, Lakka TA, Laakso M, Tuomilehto J, Parker SCJ, Koistinen HA, Davey Smith G, Boehnke M, Scott LJ, Birney E, Collins FS. Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle. Proc Natl Acad Sci U S A. 2019;116:10883-8.

5. Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Zelniker TA, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Ruff CT, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde AM, Sabatine MS; DECLARE–TIMI 58 Investigators (Tuomilehto J). Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2019;380:347-57.

6. Hebbar P, Abu-Farha M, Alkayal F, Nizam R, Elkum N, Melhem M, John SE, Channanath A, Abubaker J, Bennakhi A, Al-Ozairi E, Tuomilehto J, Pitkaniemi J, Alsmadi O, Al-Mulla F, Thanaraj TA. Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population. Sci Rep. 2020;10:152.

7. Tuomilehto J, Ogle GD, Lund-Blix NA, Stene LC. Update on Worldwide Trends in Occurrence of Childhood Type 1 Diabetes in 2020. Pediatr Endocrinol Rev. 2020;17(Suppl 1):198-209.

8. Chen J, Marenne G, Varshney A, Willems SM, Wu Y, Horikoshi M, Ray D, Sim X, Southam L, Stewart, ID, Ahluwalia TS, Appel EVR, Burtt NP, Chai JF, Chang LC, Chen CH, Giulianini F, Hartwig FP, He J, Kawaguchi T, Kim YJ, Kleber ME, Lai S, Ligthart S, Montasser ME, Nag A, Nakatochi M, Sanna S, Schraut KE, Strawbridge RJ, van der Most PJ, Wang H, Wilsgaard T, Xie T, Arzumanyan Z, Cai Q, Eiriksdottir G, Hsieh CH, Jørgensen ME, Kandeel FR, Khor CC, Kiess W, Kuulasmaa T, Läll K, Lemaitre RN, Linneberg A, Matsubara T, Mooijaart S, Nadler JL, Peters A, Qi Q, Stringham HM, Thuesen B, Adair LS, An P, Bisgaard H, Boerwinkle E, Bottinger EP, Chambers JC. Chasman DI, Cheng CY, Collins FS, Cucca F, Evans MK, Florez JC, Franks PW, Gudnason V, Hamsten A, Heckbert SR, Ingelsson E, Kuh D, Kumari M, Lakka TA, Launer LJ, Lindgren C, Mahajan A, Metspalu A, Palmer ND, Pedersen O, Pennell CE, Psaty BM, Qi L, Redline SSandhu M, Snieder H, Sørensen TIA, Sun L, Tabara Y, Tai ES, Timpson NJ, Tuomilehto J, Vitart V, Vollenweider P, Willemsen G, Wilson JF, Zeggini E, Gloyn AL, Meigs JB Langenberg C, Barroso I, van Willems van Dijk K. The trans-ancestral genomic architecture of glycemic traits Nat Genetics, 2021;.53:840-60.

9. Lehtisalo J, Rusanen M, Solomon A, Antikainen R, Laatikainen T, Peltonen M, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M, Ngandu T. Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial. Eur Heart J. 2022 Jan 20:ehab922. doi: 10.1093/eurheartj/ehab922. Online ahead of print.

10. Ruuskanen MO, Erawijantari PP, Havulinna AS, Liu Y, Méric G, Tuomilehto J, Inouye M, Jousilahti P, Salomaa V, Jain M, Knight R, Lahti L, Niiranen TJ. Gut Microbiome Composition Is Predictive of Incident Type 2 Diabetes in a Population Cohort of 5,572 Finnish Adults. Diabetes Care. 2022 Jan 31:dc212358. doi: 10.2337/dc21-2358. Online ahead of print