Michele Vendruscolo - Selected Publications#

Over 300 scientific papers. H-index 70 (Google Scholar)

Ten representitive publications include:

1. F. A. Aprile, P. Sormanni, M. Perni, P. Arosio, S. Linse, T. P. J. Knowles, C. M. Dobson and M. Vendruscolo.
Selective targeting of primary and secondary nucleation pathways in Abeta42 aggregation using a rational antibody scanning method. Sci. Adv. 3, e1700488 (2017).

2. J. Habchi, S. Chia, R. Limbocker, B. Mannini, M. Ahn, M. Perni, O. Hansson, P. Arosio, J. R. Kumita, P. K. Challa, S. I. A. Cohen, S. Linse, C. M. Dobson, T. P. J. Knowles and M. Vendruscolo.
Systematic development of small molecules to inhibit specific microscopic steps of Abeta42 aggregation in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 114, E200-E208 (2017).

3. R. Freer, P. Sormanni, G. Vecchi, P. Ciryam, C. M. Dobson and M. Vendruscolo.
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease.
Sci. Adv. 2, e1600947 (2016).

4. J. Habchi, P. Arosio, M. Perni, A. R. Costa, M. Yagi-Utsumi, P. Joshi, S. Chia, S. I. A. Cohen, M. B. D. Muller, S. Linse, E. A. A. Nollen, C. M. Dobson, T. P. J. Knowles and M. Vendruscolo.
An anti-cancer drug suppresses the primary nucleation reaction that initiates the formation of toxic Abeta aggregates linked with Alzheimer's disease.
Sci. Adv. 2, e1501244 (2016).

5. M. Bonomi, C. Camilloni, A. Cavalli and M. Vendruscolo.
Metainference: A Bayesian inference method for heterogeneous systems.
Sci. Adv. 2, e1501177 (2016).

6. P. Sormanni, F. A. Aprile and M. Vendruscolo.
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins.
Proc. Natl. Acad. Sci. USA, 112, 9902-9907 (2015).

7. A. Cavalli, X. Salvatella, C. M. Dobson and M. Vendruscolo.
Protein structure determination from NMR chemical shifts.
Proc. Natl. Acad. Sci. USA, 104, 9615-9620 (2007).

8. G. G. Tartaglia, S. Pechmann, C. M. Dobson and M. Vendruscolo.
Life on the edge: A link between gene expression levels and aggregation rates of human proteins.
Trends Biochem. Sci. 32, 204-206 (2007).

9: Lindorff-Larsen K, Best RB, Depristo MA, Dobson CM, Vendruscolo M.
Simultaneous determination of protein structure and dynamics. Nature. 433, 128-132 (2005).

10: Vendruscolo M, Paci E, Dobson CM, Karplus M. Three key residues form a
critical contact network in a protein folding transition state. Nature. 409, 641-645 (2001).