Graham Richard Williams - Selected Publications#

203 publications; 13344 citations; H-index 64

McDonald MM, Khoo WH, Ng PY, Xiao Y, Zamerli J, Thatcher P, Kyaw W, Pathmanandavel K, Grootveld AK, Moran I, Butt D, Nguyen A, Warren S, Biro M, Butterfield NC, Guildfoyle SE, Komla-Ebri D, Dack MRG, Dewhurst HF, Logan JG, Li Y, Mohanty ST, Byrne N, Terry RL, Simic MK, Chai R, Quinn JMW, Youlten SE, Pettitt JA, Abi-Hanna D, Jain R, Weninger W, Lundberg M, Sun S, Ebetino H, Timpson P, Lee WM, Baldock PA, Rogers MJ, Brink R, Williams GR, Bassett JHD, Kemp JP, Pavlos NJ, Croucher PI, Phan TG (2021) Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption. CELL 184(5):1330-1347.
(Discovery of a new cell type through which bone resorbing osteoclasts recycle to regulate bone mass)

Youlten SE, Kemp JP, Logan JG, Ghirardello EJ, Sergio CM, Dack MRG, Guilfoyle SE, Leitch VD, Butterfield NC, Komla-Ebri D, Chai RC, Corr AP, Smith JT, Morris JA, McDonald MM, Quinn JMW, McGlade AR, Bartonicek N, Jansson M, Hatzikotoulas K, Irving MD, Beleza-Meireles A, Rivadeneira F, Duncan E, Richards JB, Adams DJ, Lelliot CJ, Brink R, Phan TG, Eisman JA, Evans DM, Zeggini E, Baldock PA, Bassett JHD*, Williams GR*, Croucher PI* (2021) An osteocyte transcriptome map identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease. NATURE COMMUNICATIONS 12: 2444 DOI: 10.1038/s41467-021-22517-1.
(Key evidence that the osteocyte transcriptome is a major determinant of monogenic and complex human skeletal disease)

Steinberg J, Southam L, Roumeliotis TI, Clark MJ, Jayasuriya RL, Swift D, Shah KM, Butterfield NC, Brooks RA, McCaskie AW, Bassett JHD, Williams GR, Choudhary JS, Wilkinson JM, Zeggini E (2021) A molecular quantitative trait locus map for osteoarthritis. NATURE COMMUNICATIONS 12(1), 1309 DOI: 10.1038/s41467-021-21593-7.
(Integration of multi 'omics data to identify new therapeutic targets and generate the first molecular QTL map for osteoarthritis)

Butterfield NC, Curry KF, Steinberg J, Dewhurst H, Komla-Ebri D, Mannan NS, Adoum A-T, Leitch VD, Logan JG, Waung JA, Ghirardello E, Southam L, Youlten SE, Wilkinson JM, McAninch EA, Vancollie VE, Kussy F, White JK, Lelliott CJ, Adams DJ, Jacques R, Bianco AC, Boyde A, Zeggini E, Croucher PI, Williams GR*, Bassett JHD* (2021) Accelerating functional gene discovery in osteoarthritis. NATURE COMMUNICATIONS 12(1), 467 DOI: 10.1038/s41467-020-20761-5.
(Invention of novel imaging approaches for functional validation of osteoarthritis genes in vivo)

Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC, Vulpescu NA, Forgetta V, Kleinman A, Mohanty ST, Sergio CM, Quinn JMW, Nguyen-Yamamoto L, Luco AL, Vijay J, Simon M-M, Pramatarova A, Medina-Gomez C, Trajanoska K, Ghirardello EJ, Butterfield NC, Curry KF, Leitch VD, Sparkes PC, Adoum A-T, Mannan NS, Komla-Ebri DSK, Pollard AS, Dewhurst HF, Hassall T, Beltejar M-JG, Adams DJ, Vaillancourt SM, Kaptoge S, Baldock PA, Cooper C, Reeve J, Ntanzi E, Evangelou V, Ohlsson C, Karasik D, Rivadeneira F, Kiel DP, Tobias JH, Gregson CL, Harvey NC, Grundberg E, Goltzman D, Adams DJ, Lelliot CJ, Hinds DA, Ackert-Bicknell CL, Hsu Y-H, Maurano MT, Croucher PI, Williams GR, Bassett JHD, Evans DM, Richards JB (2019) An atlas of genetic influences on osteoporosis in humans and mice. NATURE GENETICS 51(2):258-266.
(Identification of 518 bone density and 13 fracture loci in humans with functional validation of 53 genes in knockout mice)

Rauner M, Baschant U, Roetto A, Pellegrino RM, Rother S, Salbach-Hirsch J, Weidner H, Hintze V, Campbell G, Petzold A, Lemaitre R, Henry I, Bellido T, Theurl I, Altamura S, Colucci S, Muckenthaler MU, Schett G, Komla-Ebri DSK, Bassett JHD, Williams GR, Platzbecker U, Hofbauer LC (2019) Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling. NATURE METABOLISM 1:111-124.
(Discovery of transferrin receptor 2 extracellular domain as a novel therapeutic option for heterotopic ossification)

Jo S, Fonseca TL, Bocco BMLC, Fernandes GW, McAninch EA, Bolin AP, Da Conceiçã RR, Egri P, Németh D, Fekete C, Bernardi MM, Leitch VD, Mannan NS, Curry KF, Butterfield NC, Bassett JHD, Williams GR, Gereben B, Ribeiro MO, Bianco AC (2019) Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the mouse brain. JOURNAL OF CLINICAL INVESTIGATION 129(1):230-245.
(Key evidence that type 2 deiodinase is a diverse tissue-specific thyroid hormone activating enzyme in vivo)

Hönes GS, Rakov H, Logan JG, Liao XH, Werbenko E, Pollard AS, Praestholm SM, Siersbaek MS, Rijntjes E, Gassen J, Latteyer S, Engels K, Strucksberg KH, Kleinbongard P, Zwanziger D, Rozman J, Gailus-Dorner V, Fuchs H, Hrabe de Angelis M, Klein-Hitpass L, Köhrle J, Armstrong DL, Grontved L, Bassett JHD, Williams GR, Refetoff S, Führer D, Moeller LC (2017) Non-canonical thyroid hormone signaling mediates cardiometabolic effects in vivo. PROCEEDINGS OF THE NATIONAL ACADAMY OF SCIENCES USA 114(52):E11323-E11332.
(Discovery of organ-specific canonical and non-canonical thyroid hormone receptor signaling in diverse tissues)

Kemp JP, Morris JA, Medina-Gomez C, Forgetta V, Warrington NM, Youlten SE, Zheng J, Gregson CL, Grundberg E, Trajanoska K, Logan JG, Pollard AS, Sparkes PC, Ghirardello EJ, Allen R, Leitch VD, Butterfield NC, Komla-Ebri DSK, Adoum A-T, Curry KF, White JK, Kussy F, Greenlaw K, Xu CJ, Harvey NC, Cooper C, Adams DJ, Greenwood CMT, Maurano MT, Kaptoge S, Rivadeneira F, Tobias JH, Croucher PI, Ackert-Bicknell CL, Bassett JHD, Williams GR, Richards JB, Evans DM (2017) Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. NATURE GENETICS 49(10):1468-1475.

(Critical evidence for heparan sulfate core proteins, synthetic and modifying enzymes as determinants of bone density)

Bassett JHD, Boyde A, Howell PGT, Bassett RH, Galliford TM, Archanco M, Evans H, Croucher PI, St. Germain DL, Galton VA, Williams GR (2010) Optimal bone mineralization and strength requires the type 2 iodothyronine deiodinase in osteoblasts. PROCEEDINGS OF THE NATIONAL ACADAMY OF SCIENCES USA 107(16):7604-7609.
(Seminal discovery of role for thyroid hormone metabolism in control of bone mass and strength)