Irma Paula Nathalia Thesleff #

Selected publications 1990-2008 (out of a list of over 270)

Vainio, S., Karavanova, I., Jowett, A., Thesleff, I. Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 75: 45-58, 1993.

Jowett, A.K., Vainio, S., Ferguson, M.W.J., Sharpe, P.T., Thesleff,I. Epithelial-mesenchymal interactions are required for msx 1 and msx 2 gene expression in the developing murine molar tooth. Development 117: 461-470, 1993.

Mitsiadis, T., Muramatsu, T., Muramatsu, H., Thesleff, I. Midkine (MK), a heparing-binding growth/differentiation factor, is regulated by retinoic acid and epithelial-mesenchymal interactions in the developing mouse tooth, and affects cell proliferation and morphogenesis. J Cell Biol. 129: 267-281, 1995

Mitsiadis, T.A., Lardelli, M., Lendahl, U., Thesleff, I. Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate. J. Cell Biol. 130: 407-418, 1995.

Jernvall, J., Åberg, T., Kettunen, P., Keränen, S., Thesleff, I. The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot. Development 125:161-169, 1998

Kim, H-J., Rice, D.P.C., Kettunen, P.J., Thesleff, I. FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development 125:1241-1251, 1998

D´Souza, R.N., Åberg, T., Gaikwad, J., Cavender, A., Owen , M., Karsenty, G.,Thesleff, I. Cbfa 1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development 126:2911-2920, 1999

Mikkola, M., Pispa, J., Pekkanen, M., Paulin, L., Nieminen, P., Kere, J., Thesleff, I. Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion. Mech. Dev. 88:133-146, 1999

Harada, H., Kettunen, P., Jung, H-S., Mustonen, T., Wang, Y.A., Thesleff, I. Localization of putative stem cells in dental epithelium and their association Notch and FGF signaling. J. Cell Biol. 147:105-120, 1999

Pispa, J., Jung, H-S., Jernvall, J., Kettunen, P., Mustonen, T., Kere, J., Thesleff, I. Cusp patterning defect in Tabby mice teeth and its partial rescue by FGF. Dev. Biol. 216:521-534, 1999

Rice, P., Åberg. T., Chan, Y-S., Kettunen, P., Pakarinen, L., Maxson, R.E., Thesleff,I. Integration of FGF and TWIST in calvarial bone and suture development. Development 127:1845-1855, 2000

Jernvall, J., Keränen, S.V.E., Thesleff, I. Evolutionary modification of development in mammalian teeth: Quantifying gene expression patterns and topography. Proc. Nat. Acad. Sci. USA 97:14444-14448, 2000

Jernvall, J., Thesleff, I. Reiterative signaling and patterning in mammalian tooth morphogenesis. Mech. Dev. 92: 19-29, 2000.

Laurikkala, J., Mikkola, M., Mustonen, T., Åberg, T., Koppinen, P., Pispa, J., Nieminen, P., Galceran, J., Grosshedl, R., Thesleff, I. TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during organogenesis. Dev.Biol. 229: 443-455,2001

Laurikkala J, Pispa, J., Jung H-S, Nieminen P, Mikkola M, Wang X, Saarialho-Kere U., Galceran, J., Grosschedl, R., Thesleff I. Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar. Development 129:2541-2553, 2002

Mustonen, T., Tummers, M., Mikami, T., Itoh, N., Zhang, N., Gridley, T., Thesleff, I. Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth. Dev. Biol. 248:281-293, 2002

Tummers,M. and Thesleff, I.: Root or crown: a developmental choice orchestrated by the differential regulation of the epithelial stem cell niche in the tooth of two rodent species. Development 130:1049-1057, 2003.

Mustonen, T. Pummila, M., Kangas, A., Mikkola, M. Pakkasjärvi, L., Pispa, J., Jaatinen, R., Thesleff, I.: Ectodysplasin-A1 stimulates the development of ectodermal organs. Dev. Biol. 253: 123-136, 2003

Pispa, J., Thesleff, I.: Mechanisms of ectodermal organogenesis. Dev. Biol. 262: 195-205, 2003

Laurikkala, J., Kassai, Y., Pakkasjärvi, L., Thesleff, I., Itoh, N.: Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF and SHH signals from the tooth enamel knot. Dev. Biol. 264: 91-105, 2003

Lammi, L., Arte, S., Somer, M., Järvinen, H., Lahermo, P., Thesleff, I., Pirinen, S., Nieminen, P.: Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am. J. Hum. Genet. 74: 1043-50, 2004

Åberg, T., Wang, X-P., Kim, J-H., Yamashiro, T., Bei, M., Rice, R., Ryoo, H-M., Thesleff, I.: Runx2 mediates FGF signalling from epithelium to mesenchyme during tooth morphogenesis. Dev. Biol. 270: 76-93, 2004

Wang, X-P., Suomalainen, M., Jorgez, C.j., Matzuk, M.M., Werner, S., and Thesleff, I.: Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signalling and ameloblast differentiation. Dev. Cell 7: 719-730, 2004

Kangas, A.T., Evans, A.R., Thesleff, I., Jernvall, J.: Non-independence of mammalian dental characters. Nature 432: 211-214, 2004

Kassai, Y., Munne, P., Hotta, Y., Penttilä, E., Kavanagh, K., Ohbayashi, N., Takada, S., Thesleff, I., Jernvall, J., Itoh, N.: Regulation of mammalian cusp patterning by ectodin. Science 309: 2067-2070, 2005.

Laurikkala, J., Mikkola, M.L., James, M., Tummers, M., Mills, A., Thesleff, I.: P63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation Development 133: 1553-1563, 2006.

Järvinen, E., Salazaar-Ciudad, I., Birchmeier, W., Taketo, M.M., Jernvall, J., Thesleff, I. Continuous tooth generation in mouse is induced by activated epithelial Wnt/ ßcatenin signalling. Proc. Natl. Acad. Sci USA 103: 18627-18632, 2006.

Pummila, M., Fliniaux, I., Jaatinen, R., James, M., Laurikkala, J., Schneider, P., Thesleff, I., Mikkola, M.L. Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of BMP activity and induction of Shh expression. Development 134: 117-125, 2007.

Wang, X-P., Suomalainen, M, Felszeghy, S., Zelarayan, L.C., Alonso, M.T., Plikus, M.V., Maas, R., Chuong, C-M., Schimmang, T., Thesleff, I. An integrated gene regulatory network controls epithelial stem cell proliferation in teeth. PLoS Biology 5: 1324-1333, 2007

Närhi, K., Järvinen, E, Birchmeier, W., Taketo, M., M., Mikkola, M.M., Thesleff,I. Sustained epithelial {beta}-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development 135:1019-1028, 2008