Xiaoyuan Chen - Selected Publications#

1. Cao F, Jin L, Gao Y, Ding Y, Wen H, Qian Z, Zhang C, Hong L, Yang H, Zhang J, Tong Z, Wang W, Chen X*, Mao Z*. Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis. Nat Nanotechnol. 2023;18(6):617-627. (IF 38.3). Significance: A ground-breaking chemical engineering strategy to improve the performance of probiotics to treat inflammatory bowel disease by reshaping the intestinal barrier functions and restoring the gut microbiota. This formula has been submitted to HSA for clinical translation.

2. Shi C, Zhang Q, Yao Y, Zeng F, Du C, Nijiati S, Wen X, Zhang X, Yang H, Chen H, Guo Z, Zhang X, Gao J, Guo W, Chen X*, Zhou Z*. Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics. Nat Nanotechnol. 2023;18(1):86-97. (IF 38.3). Significance: This is an elegant design of nanodecoy to measure T cell activity by non-invasive MR imaging and reactivate exhausted T cells to improve various forms of adoptive T cell therapy, including CAR-T therapy.

3. Huang P, Jiang L, Pan H, Ding L, Zhou B, Zhao M, Zou J, Li B, Qi M, Deng H, Zhou Y, Chen X*. An Integrated Polymeric mRNA Vaccine without Inflammation Side Effects for Cellular Immunity Mediated Cancer Therapy. Adv Mater. 2023;35(3):e2207471. (IF 29.4). Significance: This study reported a series of alternating copolymer-based mRNA cancer vaccine vectors that are potent and yet have negligible inflammatory side effects as a replacement of the currently used lipid nanoparticles (LNP).

4. Bhatia S, Chen X*, Dobrovolskaia M, Lammers T. Cancer Nanomedicine. Nat Rev Cancer, 2022;22:550–556. (IF 78.5). Significance: This is an expert opinion about how we can fulfil the great promise of nanomedicine for the detection, diagnosis, and treatment of patients with cancer. This paper also lays ground for future research direction and clinical translation of cancer nanomedicine.

5. Tian R, Feng X, Wei L, Dai D, Ma Y, Pan H, Ge S, Bai L, Ke C, Liu Y, Lang L, Zhu S, Sun H, Yu Y, Chen X*. A genetic engineering strategy for editing near-infrared-II fluorophores. Nat Commun. 2022;13(1):2853. (IF 16.6). Significance: This is the first of its kind genetic strategy to design optical dyes in the second near-infrared window for non-invasive, real-time, and highly sensitive imaging of molecular/cellular level activities.

6. Liu C, Liu X, Xiang X, Pang X, Chen S, Zhang Y, Ren E, Zhang L, Liu X, Lv P, Wang X, Luo W, Xia N, Chen X*, Liu G. A nanovaccine for antigen self-presentation and immunosuppression reversal as a personalized cancer immunotherapy strategy. Nat Nanotechnol. 2022;17(5):531-540. (IF 38.3). Significance: This breakthrough engineering technology modified dendritic cell membrane and formulated a novel vaccine which showed high efficacy in the treatment of solid tumors, achieving complete clearance of solid tumors and inducing long-lasting immune memory.

7. Li L, Zou J, Dai Y, Fan W, Niu G, Yang Z, Chen X. Burst release of encapsulated annexin A5 in tumours boosts cytotoxic T-cell responses by blocking the phagocytosis of apoptotic cells. Nat Biomed Eng. 2020;4(11):1102-1116. (IF 29.2). Significance: This study develops a novel in situ cancer vaccination approach by reducing apoptosis signaling for the generation of systemic cytotoxic T-cell responses and immunological memory.

8. Chen H, Zhang W, Zhu G, Xie J, Chen X. Rethinking cancer nanotheranostics. Nat Rev Mater. 2017;2:17024. (IF 76.7). Significance: This review article emphasizes the importance of in vitro diagnostics and in vivo imaging in patient stratification, drug-release monitoring, imaging-guided focal therapy and post-treatment response monitoring. It also articulates how we can better conduct preclinical testing of nanotechnologies to better translate nanomedicine into clinics.

9. Book: Cancer Theranostics (co-editor: Stephen Wong; Publisher: Elsevier) ISBN 978-0-12-407722-5. No. of pages: 544. Published: March 20, 2014. Paperback ISBN: 9780128102992. Hardback ISBN: 9780124077225. eBook ISBN: 9780124078840. This book describes the identification of novel biomarkers to advance molecular diagnostics of cancer. It encompasses new molecular imaging probes and techniques for early detection of cancer and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives.